Effects of 6-hydroxydopamine upon primary and secondary thymus dependent immune responses

Hall, Nicholas R.; McClure, John E.; Hu, Shu-Kuang; Tare, Nadine S.; Seals, C; Goldstein, Allan L.

doi:10.1016/0162-3109(82)90035-2

Cited by 62 publications

(13 citation statements)

References 12 publications

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“…Chemical sympathectomy decreases bacterial loads and increases innate immune responses to Listeria monocytogenes (16). However, 6-OHDA-treated mice have also exhibited decreased antibody responses to sheep red blood cells (17), although the extent of inhibition varies between inbred mouse strains (6). Of note, immune responses to antigen and mitogen are dramatically different in chemically sympathectomized mice.…”

mentioning

confidence: 96%

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Grebe

Hickman

Irvine

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8 ؉ T cell responses to viral and cellular antigens presented by direct priming or crosspriming. The sympathetic nervous system also suppresses antiviral CD4 ؉ T cell responses, but this is not required for suppressing CD8 ؉ T cell responses. Adoptive transfer experiments indicate that enhanced CD8 ؉ responses do not result from permanent alterations in CD8 ؉ T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate naïve CD8 ؉ T cells. We also show that antiviral CD8 ؉ T cell responses are enhanced by administration of a ␤2 (but not ␤1 or ␣) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8 ؉ T cell responses and indicate that CD8 ؉ T cell responses may be altered in patients using ␤-blockers, one of the most widely prescribed classes of drugs.antigen presentation ͉ vaccine ͉ cross-priming ͉ direct-priming ͉ dendritic cell

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mentioning

confidence: 96%

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Grebe

Hickman

Irvine

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…In vivo studies employing chemical sympathectomy in adult rodents prior to antigen challenge with a T-cell dependent antigen reduces [54,91,145,[226][227][228] or enhances [13,229,230] antibody production. Chemical sympathectomy in C57Bl/6 mice, a strain with a predominant Th1 antibody profile, enhances Th1-associated serum IgG 2a and Th2-associated IgG 1 production after immunization with keyhole limpet hemocyanin (KLH).…”

Section: Functional Significance Of Sympathetic Innervation Of Secondmentioning

confidence: 99%

Sympathetic modulation of immunity: Relevance to disease

Bellinger

Millar

Perez

et al. 2008

Cellular Immunology

226

185

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Optimal host defense against pathogens requires cross-talk between the nervous and immune systems. This paper reviews sympathetic-immune interaction, one major communication pathway, and its importance for health and disease. Sympathetic innervation of primary and secondary immune organs is described, as well as evidence for neurotransmission with cells of the immune system as targets. Most research thus far as focused on neural-immune modulation in secondary lymphoid organs, and have revealed complex sympathetic modulation resulting in both potentiation and inhibition of immune functions. SNS-immune interaction may enhance immune readiness during disease-or injury-induced 'fight' responses. Research also indicate that dysregulation of the SNS can significantly affect the progression of immune-mediated diseases. However, a better understanding of neural-immune interactions is needed to develop strategies for treatment of immune-mediated diseases that are designed to return homeostasis and restore normal functioning neural-immune networks.

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“…In adult animals, NE depletion with 6-OHDA is relatively short-lived, since nerve terminals, but not cell bodies, are destroyed; however, local injection of 6-OHDA at sites of lymph nodes can selectively denervate NA fibers from these organs while leaving all other pe ripheral NA fibers intact. In neonatally sympathectomized animals and in adult animals which had been surgically sympathectomized (another means of long-term sympathectomy, but accompanied by additional damage to incoming or outgoing neuropeptide systems), adult animals demonstrated enhanced anti body responses [61,62], In animals chemi cally sympathectomized as adults, antibody responses to T-dependcnt antigens, delayedtype hypersensitivity, and IL-2 production were reduced [63][64][65][66], while antibody re sponses to a T-independent antigen were en hanced [67]. These divergent results have not yet been fully explained on the individual cel lular level, but they suggest that there may be a dichotomy of responsiveness to catechol amines by T and B cells.…”

Section: Neurotransmitter Influences On Immune Functionmentioning

confidence: 99%

Fundamental Aspects of Neural-Immune Signaling

Felten

Bellinger

et al. 1993

Psychother Psychosom

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Noradrenergic and peptidergic nerve fibers abundantly innervate the parenchyma of both primary (bone marrow) and secondary (spleen, lymph nodes) lymphoid organs. Nerve fibers distribute within the parenchyma of these organs, as well as along smooth muscle compartments. Both noradrenaline and peptides such as substance P have been shown to fulfill the basic criteria for neurotransmission with lymphocytes, macrophages, and other immunocytes as targets. Denervation or pharmacological manipulation of these neurotransmitters can profoundly alter immunological reactivity at the individual cellular level, at the level of complex multicellular interactions (such as antibody response), and at the level of host response to a disease-producing challenge. The characteristic and mechanisms of bidirectional neural-immune signaling may provide a novel approach to immunologically-mediated disease, both pharmacologically and behaviorally.

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Effects of 6-hydroxydopamine upon primary and secondary thymus dependent immune responses

Cited by 62 publications

References 12 publications

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Sympathetic modulation of immunity: Relevance to disease

Fundamental Aspects of Neural-Immune Signaling

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Effects of 6-hydroxydopamine upon primary and secondary thymus dependent immune responses

Cited by 62 publications

References 12 publications

Sympathetic nervous system control of anti-influenza CD8+T cell responses

Sympathetic nervous system control of anti-influenza CD8+T cell responses

Sympathetic modulation of immunity: Relevance to disease

Fundamental Aspects of Neural-Immune Signaling

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Product

Resources

About

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses

Sympathetic nervous system control of anti-influenza CD8⁺T cell responses