Effects of 780 nm diode laser irradiation on blood microcirculation: preliminary findings on time-dependent T1-weighted contrast-enhanced magnetic resonance imaging (MRI)

Schaffer, Moshe; Bonél, Harald; Sroka, Ronald; Schaffer, Pamela; Busch, M.; Reiser, Maximilian; Dühmke, Eckhart

doi:10.1016/s1011-1344(99)00155-4

Cited by 94 publications

(55 citation statements)

References 19 publications

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“…7,10,[19][20][21][22] Since blood flow is increased in the microcirculation during laser therapy, this could explain the enhancement of wound healing and reduced pain. 6,7 Others have suggested that LLLT is beneficial for wound healing in diabetics. They reported that LLLT, at 830 nm, significantly enhanced cutaneous wound tensile strength in a murine diabetic model.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have demonstrated that lowlevel laser therapy (LLLT) stimulates wound healing, by increasing collagen deposition and blood flow in the wound area. [6][7][8][9][10][11][12][13] Some lasers, when used with the proper parameters, affect fibroblasts and collagen production in vitro, and promising results have been found utilizing the HeNe laser (632.8 nm) with multiple exposures. 9,[14][15][16][17][18][19] One effect of laser therapy (5 J/cm 2 ) is increased local blood flow in normal human skin of the sole of the foot.…”

Section: Introduction Dmentioning

confidence: 99%

“…9,[14][15][16][17][18][19] One effect of laser therapy (5 J/cm 2 ) is increased local blood flow in normal human skin of the sole of the foot. 6 A comparative study of LLLT on fibroblasts in vitro, using fluence of 2 J/cm 2 and various irradiances, concluded that the proliferation rate of human gingival fibroblasts was increased when under conditions of nutritional deficit and stress. 14 Laser parameters (such as wavelength, time of exposure, and dosage) used for in vivo studies of the effect of LLLT on wound healing have not been standardized yet.…”

Section: Introduction Dmentioning

confidence: 99%

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Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

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Objective: The aim of this work was to compare the effect of low-level laser therapy (LLLT) on the wound healing process in nondiabetic and diabetic rats. Background Data: Among the clinical symptoms caused by diabetes mellitus, a delay in wound healing is a potential risk for patients. It is suggested that LLLT can improve wound healing. Methods: The tissue used for this study was extracted from animals suffering from diabetes, which was induced by Streptozotocin ® , and from nondiabetic rats. Animals were assembled into two groups of 25 rats each (treated and control) and further subdivided into two groups: diabetic (n = 15) and nondiabetic (n = 10). A full-thickness skin wound was made on the dorsum area, with a round 8-mm holepunch. The treated group was irradiated by a HeNe laser at 632.8 nm, with the following parameters: 15 mW, exposition time of 17 sec, 0.025 cm 2 irradiated area, and energy density of 10 J/cm 2 . Square full-thickness skin samples (18 mm each side, including both injured and noninjured tissues) were obtained at 4, 7, and 15 days after surgery and analyzed by qualitative and quantitative histological methods. Results: Quantitative histopathological analysis confirmed the results of the qualitative analysis through histological microscope slides. When comparing tissue components (inflammatory cells, vessels and fibroblast/area), we found that treated animals had a less intense inflammatory process than controls. Conclusion: Results obtained by both qualitative and quantitative analyses suggested that irradiation of rats with HeNe (632.8 nm), at the tested dose, promoted efficient wound healing in both nondiabetic and diabetic rats as, compared to the control group. 474

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Section: Discussionmentioning

confidence: 99%

Section: Introduction Dmentioning

confidence: 99%

Section: Introduction Dmentioning

confidence: 99%

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Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

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“…The literature indicates that photobiomodulation accelerates wound healing and promotes angiogenesis 25,26 , which can be used to justify the results reported in this paper.…”

Section: G1 (%) G2 (%) G3 (%) G4 (%)mentioning

confidence: 52%

The effects of different doses of 670 nm diode laser on skin flap survival in rats

et al. 2012

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PURPOSE: To investigate the effects of different low-level laser therapy (LLLT) doses on random skin flap rats. METHODS: Forty Wistar rats were randomly divided in four groups. The control group (CG) was not irradiated. The experimental groups were irradiated with a diode laser 670 nm with different energies per point: group 2 (G2) with 0.06 J; group 3 (G3) 0.15 J and group 4 (G4) 0.57 J. The three groups were irradiated in 12 equally distributed points in the cranial skin flap portion. They were submitted to the irradiation during the immediate, first and second postoperative days. The necrosis area was evaluated in the seventh postoperative day. RESULTS: The CG shows 49.35% of necrosis area in the skin flap; G2, 39.14%; G3, 47.01% and G4, 29.17% respectively. There was a significantly difference when G4 was compared with CG`s skin flap necrosis area. CONCLUSION: The low-level laser therapy diode 670 nm with 0.57 J energy per point increases the survival in randomic skin flap rats.

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“…The laser light (especially red) expands micro vessels, increases the blood flow, accompanied by better oxygenation, increases lymphatic drainage and metabolism in the affected tissues, which also contributes to alleviation of pain [29,[35][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

Analgesic Effects of the Polarized Red+Infrared LED Light

Gulyar¹,

Tamarova²

2017

UCMS

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INTRODUCTION: Our previous studies have shown that exposure of acupuncture points (AP) or painful area of mice to halogen polarized light (PL) effectively weakens the pain. The aim of the study was to determine whether exposure of AP or painful area to LED red-infrared PL evokes analgesic effect. METHODS: The duration of licking the formalin-injected foot (tonic pain) was recorded in control group and mice exposed (5 min, 10 min) to red+infrared LED light on AP E-36 or on the painful area. Power density of the light varied from 0.3 to 16.5 mW/cm 2 . RESULTS: Exposure of AP E-36 or painful area to red-infrared LED PL evoked statistically significant decrease of licking time. The effect depended on the light application duration and its power density. 10-minute light exposition was more effective than 5-minute. The exposure of pain source to LED PL shortened the licking time to 44.1% (at 16.5 mW/cm 2 ) and to 64.4% (at 0.3 mW/cm 2 ). CONCLUSION: The results show the efficacy of pain suppression by exposure of antinociceptive AP or painful area to LED red+infrared PL. The effect depends on the duration of light exposure and its power density.

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Effects of 780 nm diode laser irradiation on blood microcirculation: preliminary findings on time-dependent T1-weighted contrast-enhanced magnetic resonance imaging (MRI)

Cited by 94 publications

References 19 publications

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

The effects of different doses of 670 nm diode laser on skin flap survival in rats

Analgesic Effects of the Polarized Red+Infrared LED Light

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