Effects of a Bronchoprovocation Challenge Test With Cigarette Sidestream Smoke on Sensitive and Healthy Adults

Danuser, Brigitta; Wéber, A.; Hartmann, Andrea; Krueger, Helmut

doi:10.1378/chest.103.2.353

Cited by 36 publications

(25 citation statements)

References 20 publications

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“…Controlled chamber exposure studies support the biologic plausibility of ETSrelated asthma exacerbation. After shortterm exposure of 1-3 hr, many asthmatics experience a decline in FEV 1 (50)(51)(52)(53). Pretreatment with bronchodilators appears to prevent the acute decline in FEV 1 in previously reactive subjects (54).…”

Section: Discussionmentioning

confidence: 99%

Environmental tobacco smoke exposure and pulmonary function among adults in NHANES III: impact on the general population and adults with current asthma.

Eisner

2002

Environ Health Perspect

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The impact of environmental tobacco smoke (ETS) exposure on adult pulmonary function has not been clearly determined. Because adults with asthma have chronic airway inflammation, they may be a particularly susceptible group. Using data from the Third National Health and Nutrition Examination Survey (NHANES III), I examined the cross-sectional relationship between serum cotinine, a biomarker of ETS exposure, and pulmonary function among 10,581 adult nonsmokers and 440 nonsmoking adults with asthma whose cotinine and spirometry data were available. I generated residuals, which are observed minus predicted values (based on Crapo equations), for forced expiratory volume in 1 sec (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio to adjust for age, sex, and height. In addition, I used multivariate linear regression to control for sociodemographic characteristics and previous smoking history. Most adults with and without asthma had detectable serum cotinine levels, indicating recent ETS exposure (85.7% and 83.4%, respectively). Among nonsmoking male participants, I found no evidence that ETS exposure was related to decreased pulmonary function. In the nonsmoking female stratum, the highest cotinine tertile was associated with a lower FEV1 [-100 mL; 95% confidence interval (CI), -143 to -56 mL], FVC (-119 mL; 95% CI, -168 to -69 mL), and FEV1/FVC ratio (-1.77%; 95% CI, -2.18% to -1.36%). Among women with asthma, the highest cotinine tertile was also associated with decreased FEV1 (-261 mL; 95% CI, -492 to -30 mL), FVC (-291 mL; 95% CI, -601 to 20 mL), and FEV1/FVC ratio (-1.6%; 95% CI, -3.3% to 0.19%). In conclusion, ETS exposure is associated with decreased pulmonary function in adult females, especially those with asthma. This analysis should provide further impetus for public policies that promote smoke-free environments.

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Section: Discussionmentioning

confidence: 99%

Environmental tobacco smoke exposure and pulmonary function among adults in NHANES III: impact on the general population and adults with current asthma.

Eisner

2002

Environ Health Perspect

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“…The same group demonstrated that almost one third of smoke-sensitive subjects with asthma and one fifth of smoke-sensitive subjects without asthma have a marked increase in bronchial hyperreactivity 6 h after ETS exposure [101]. DANUSER et al [102] exposed 10 hyperreactive subjects to ETS, and observed a significant decrease of FEV 1 , FVC, and MEF 50 ; a dose-response relationship was found for symptoms. However, these results were not confirmed by MAGNUSSEN and co-workers [103,104], who exposed asthmatic adults to ETS followed by bronchoprovocation test with methacholine.…”

Section: Asthmamentioning

confidence: 97%

Exposure to environmental tobacco smoke and adult non-neoplastic respiratory diseases

Trédaniel¹,

Boffetta²,

Saracci³

et al. 1994

Eur Respir J

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E Ex xp po os su ur re e t to o e en nv vi ir ro on nm me en nt ta al l t to ob ba ac cc co o s sm mo ok ke e a an nd d a ad du ul lt t n no on n--n ne eo op pl la as st ti ic c r re es sp pi ir ra at to or ry y d di is se ea as se es s On the basis of the available data, no definite conclusion (excluding the acute irritating effect of ETS on respiratory mucous membranes) can be drawn. Although biologically plausible, it remains controversial whether ETS exposure is associated with chronic respiratory symptoms and occurrence of chronic obstructive pulmonary disease, including asthma. Most of the studies that have used the most sensitive indicators of pulmonary function have suggested a negative impact of ETS exposure. However, if really present, the physiological significance of such small changes is unclear, and the relationship to long-term changes in lung function is not established. Moreover, the possibility of bias and confounding factors must be taken into account. Thus, there is a need for further epidemiological studies on ETS exposure and adult non-neoplastic respiratory disorders.

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“…There is growing evidence showing that this is also true for adults. Early experimental and epidemiologic studies reported the role of passive smoking in the development of respiratory symptoms and lung impairment, both in healthy individuals and in individuals with asthma (3)(4)(5)(6)(7). More recent studies have confirmed previous work, showing that ETS exposure is associated with a higher prevalence of respiratory symptoms, notably cough (8)(9)(10).…”

Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Respiratory Effects of Environmental Tobacco Exposure Are Enhanced by Bronchial Hyperreactivity

Gerbase

Schindler²,

Zellweger³

et al. 2006

Am J Respir Crit Care Med

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Rationale: Exposure to environmental tobacco smoke (ETS) is associated with increased reports of respiratory symptoms and reduced lung function, but the long-term effects of ETS are unclear, notably in healthy individuals with bronchial hyperresponsiveness (BHR). Objective: To assess the longitudinal effects of ETS exposure on the development of respiratory symptoms and spirometry in subjects with BHR. Methods: The study population included 1,661 never-smokers from the SAPALDIA (Swiss Study on Air Pollution and Lung Diseases in Adults) cohort, assessed in 1991 (baseline) and 11 yr later, who were symptom-free at baseline. Incident reports of respiratory symptoms and results of spirometry were assessed at the follow-up survey. Main Results: Exposure to ETS reported in the two surveys was strongly associated with the development of cough (odds ratio, 2.1; 95% confidence interval, 1.2-3.7; p ϭ 0.01). In subjects with BHR exposed to ETS at both surveys, a trend for strong associations were observed for wheeze, cough, dyspnea, and chronic bronchitis; however, the association reached statistical significance only for the symptom of dyspnea (p Ͻ 0.01). Lower FEV 1 /FVC (mean Ϯ SD, 72.9 Ϯ 7.7 vs. 76.8 Ϯ 6.1%; p Ͻ 0.01) and FEF 25-75 (forced expiratory flow, midexpiratory phase)/FVC (mean Ϯ SD, 56.1 Ϯ 22.5 vs. 68.1 Ϯ 21.6%; p Ͻ 0.01) were observed in subjects with BHR exposed to ETS compared with nonexposed subjects without BHR. Lower values were found in subjects continuing exposure by the followup survey. Conclusion: Exposure to ETS was strongly associated with the development of respiratory symptoms in previously asymptomatic subjects with BHR within 11 yr. Furthermore, subjects with underlying BHR had reduced lung function at follow-up, thus suggesting a higher risk for the development of chronic respiratory disease in this subset of the population. Keywords What This Study Adds to the FieldExposure to ETS was significantly associated with the development of respiratory symptoms within eleven years. Subjects with underlying bronchial hyperresponsiveness had reduced lung function, suggesting a higher risk for the development of chronic respiratory disease.Environmental tobacco smoke (ETS) exposure has long been established as a risk factor for the development of acute and chronic respiratory symptoms in children (1, 2). There is growing evidence showing that this is also true for adults. Early experimental and epidemiologic studies reported the role of passive smoking in the development of respiratory symptoms and lung impairment, both in healthy individuals and in individuals with asthma (3-7). More recent studies have confirmed previous work, showing that ETS exposure is associated with a higher prevalence of respiratory symptoms, notably cough (8-10). Moreover, exposure to ETS has been shown to increase the risk of chronic bronchitis and asthma in adults (11,12).However, most of the available studies examining the effects of ETS on the respiratory health of adults have been crosssectional studies (11)(12)(13). In...

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Effects of a Bronchoprovocation Challenge Test With Cigarette Sidestream Smoke on Sensitive and Healthy Adults

Cited by 36 publications

References 20 publications

Environmental tobacco smoke exposure and pulmonary function among adults in NHANES III: impact on the general population and adults with current asthma.

Environmental tobacco smoke exposure and pulmonary function among adults in NHANES III: impact on the general population and adults with current asthma.

Exposure to environmental tobacco smoke and adult non-neoplastic respiratory diseases

Respiratory Effects of Environmental Tobacco Exposure Are Enhanced by Bronchial Hyperreactivity

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