Effects of a Fish-Based Diet on the Serum Adiponectin Concentration in Young, Non-Obese, Healthy Japanese Subjects

Abstract

Aim: Adiponectin has insulin-sensitizing, anti-atherogenic, and anti-inflammatory properties, and researchers have recently reported that -3 polyunsaturated fatty acid (PUFA) can increase the serum adiponectin concentration, suggesting that dietary factors, such as fish intake, may have an influence on the serum adiponectin concentration. In general, Japanese subjects consume twice as much fish as people in other countries. We hypothesized that incremental change in serum -3 PUFA levels by fish intake is an important regulator of serum adiponectin even in Japanese subjects. The aim of this study was to explore the relationship among fish consumption, serum -3 PUFA, such as eicosapentaenoic acid (EPA), levels, and serum adiponectin levels. Method: We recruited 17 healthy Japanese volunteers (seven men and 10 women) for an 8-week fishdiet intervention ( -3 PUFA 3.0 g/day) without affecting total energy intake, and measured serum adiponectin concentration and fatty acid profiles. Results: Fish-diet intervention significantly increased the serum adiponectin concentration in women (from 13.5 4.6 to 15.8 5.2 g/mL, p 0.01) but not in men (from 8.7 2.8 to 8.7 2.5 g/mL). Serum -3 PUFA increased more in female subjects than male subjects after the fish-diet intervention (57.3 86.6 vs 150.9 46.7 g/mL, p 0.011), suggesting that changes in -3 PUFA concentration may explain the different response between sexes. Conclusion: A fish-based diet intervention increased the serum adiponectin concentration in young, non-obese, healthy Japanese female subjects. The increment in serum -3 PUFA may regulate the serum adiponectin concentration. J Atheroscler Thromb, 2010; 17:628-637.

Liver function parameters, cholesterol, and phospholipid α-linoleic acid are associated with adipokine levels in overweight and obese adults

“…Despite existing data indicating increased adiponectin levels associated with omega-3 supplementation [61,62], no significant correlations were observed to plasma phospholipid levels of omega-3 or omega-6. Conversely, leptin was significantly positively associated with plasma phospholipid levels of alpha linoleic acid.…”

The Relationship between a Mediterranean Diet and Circulating Adiponectin Levels is Influenced by Cigarette Smoking

“…Epidemiological studies have shown that people consuming a Mediterranean diet tend to have a lower risk of developing cardiovascular diseases, diabetes, and cancer 13) . At the molecular level, the beneficial effects of consuming Mediterranean diet components are believed to be mediated at least in part by their positive modulation of adiponectin [14][15][16] ; however, it is unclear whether the linear relationship between a Mediterranean diet and adiponectin is sustained under the influence of the adiponectin-lowering effects of cigarette smoking and whether this relationship is independent of potential confounders in subjects adhering long term to a Mediterranean-style diet.…”

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

“…Omega-3 fatty acid was previously reported to modulate the levels of adiponectin, leptin and adiponectin/leptin ratio. Serum adiponectin levels significantly increased following 8-week of 3 g/d of omega-3 fatty acid supplementation in healthy young female [29]. Also, an increased dietary consumption of fish was found to be associated with a reduced level of leptin [28].…”

“…Some of these nutrients includeomega-3 fatty acid [21,22], protein [23], sucrose [24], and dietary [22,25], or foods such as vegetables and fruits [26], whole grain [27], fish [28,29], and legumes [30]. However, other studies showed no association between some dietary component [s] such as vitamins and minerals with adipokine levels [31][32][33].…”