Effects of a Foot Pump on the Incidence of Deep Vein Thrombosis After Total Knee Arthroplasty in Patients Given Edoxaban

Sakai, Tatsuya; Izumi, Mitsuru; Kumagai, Kenji; Kidera, Kenichi; Yamaguchi, Takayuki; Asahara, Tomohiko; Kozuru, Hideko; Jiuchi, Yuka; Mawatari, Masaaki; Osaki, Makoto; Motokawa, Satoru; Migita, Kiyoshi

doi:10.1097/md.0000000000002247

Cited by 20 publications

(22 citation statements)

References 43 publications

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“…[23][24][25][26]28,29,[31][32][33] We identified 19 studies in these reviews that fulfilled our inclusion criteria and measured outcomes relevant to this context. 36,60,62,68,70,[104][105][106][107][108][109][110][111][112][113][114][115][116][117] Our systematic search of RCTs did not identify any additional study that fulfilled the inclusion criteria.…”

Section: Recommendationmentioning

confidence: 99%

“…36,60,62,68,104,105,107 Ten studies reported the effect on the development of symptomatic PEs, 60,62,68,70,105,107,[109][110][111]117 and 6 studies reported the effect on any PE. 36,104,108,112,116,117 Three studies reported data on symptomatic proximal DVTs, 62,70,112 and 8 studies reported data on any proximal DVT. 62,70,104,108,[112][113][114] Three studies reported data on symptomatic distal DVTs, 70,105,112 and 7 studies reported on any distal DVT.…”

Section: Recommendationmentioning

confidence: 99%

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American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

et al. 2019

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Background:Venous thromboembolism (VTE) is a common source of perioperative morbidity and mortality.Objective:These evidence-based guidelines from the American Society of Hematology (ASH) intend to support decision making about preventing VTE in patients undergoing surgery.Methods:ASH formed a multidisciplinary guideline panel balanced to minimize bias from conflicts of interest. The McMaster University GRADE Centre supported the guideline-development process, including performing systematic reviews. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess evidence and make recommendations, which were subject to public comment.Results:The panel agreed on 30 recommendations, including for major surgery in general (n = 8), orthopedic surgery (n = 7), major general surgery (n = 3), major neurosurgical procedures (n = 2), urological surgery (n = 4), cardiac surgery and major vascular surgery (n = 2), major trauma (n = 2), and major gynecological surgery (n = 2).Conclusions:For patients undergoing major surgery in general, the panel made conditional recommendations for mechanical prophylaxis over no prophylaxis, for pneumatic compression prophylaxis over graduated compression stockings, and against inferior vena cava filters. In patients undergoing total hip or total knee arthroplasty, conditional recommendations included using either aspirin or anticoagulants, as well as for a direct oral anticoagulant over low-molecular-weight heparin (LMWH). For major general surgery, the panel suggested pharmacological prophylaxis over no prophylaxis, using LMWH or unfractionated heparin. For major neurosurgery, transurethral resection of the prostate, or radical prostatectomy, the panel suggested against pharmacological prophylaxis. For major trauma surgery or major gynecological surgery, the panel suggested pharmacological prophylaxis over no prophylaxis.

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Section: Recommendationmentioning

confidence: 99%

Section: Recommendationmentioning

confidence: 99%

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

et al. 2019

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“…Edoxaban resulted more efficient in comparison to the other two prophylaxis regimens. A randomized study evaluated the effectiveness of a A-V Impulse System foot pump associated with edoxaban in the prophylaxis of DVT after TKA [51]. The authors did not find any significant difference in primary outcomes (any DVT as detected by bilateral ultrasonography up to postoperative day 10 and pulmonary embolism PE up to postoperative day 28 ) and safety outcomes ( bleeding and death of any cause up to postoperative day 28).…”

Section: Edoxabanmentioning

confidence: 96%

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

Rostagno¹,

Carulli²,

Cartei³

et al. 2016

Prog Orthop Sci

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Venous thromboembolism (VTE) is still a frequent and sometimes severe complication after knee replacement surgery. Both pharmacological and non-pharmacological measures have been widely used to decrease VTE risk. Non pharmacological treatment include measures directed to decrease the effects of blood stasis, intermittent pneumatic compression device (IPCD) and graduated compression stockings, and mechanical devices. Pharmacological prophylaxis of venous thromboembolism (VTE) is associated with a more significant decrease in the incidence of deep venous thrombosis (DVT) and related complications after knee arthroplasty however anticoagulation may increase the risk of postoperative bleeding and related complications, in particular the need for re-intervention. Aim of present review was to suggest practical approach to DVT prophylaxis in patients undergoing knee arthroplasty. Although parenteral drugs (low dose unfractionated heparin, low molecular weight heparin and fondaparinux) are the more frequently employed agents, limited compliance may be a concern. Recent studies suggest that direct oral anticoagulants, antithrombin and anti Xa agent, might be a useful alternative although safety may limited by an higher rate of local bleeding.

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“…Although there was no significant difference in the incidence of DVTs between the 2 groups (P = 0.089), the incidence of postoperative DVTs were higher in patients with the use of the foot pump (31.0%) compared to those without use of foot pump (17.7%). Modified form of figure in the article by Sakai T, et al 19) . 24) .…”

Section: Vte and Seroconversion Rate Of Anti -Pf4/heparin Antibodies mentioning

confidence: 99%

“…These data suggested that the use of mechani cal devices including foot pump, either alone or in combination with chemical thromboprophylaxis did not reduce the rate of VTE. Sakai et al conducted a randomized clinical trial to compare the effectiveness of foot pump use for reducing the incidence of DVT after TKA in patients under edoxaban thromboprophylaxis 19) . As shown in Figure 2, the incidence of all DVTs in patients using a foot pump was 31.0% (18/58) compared with 17.7% (11/62) in patients not using a foot pump.…”

Section: Incidence Of Vte In Patients Receiving Arthroplastymentioning

confidence: 99%

Induction of anti-PF4/heparin antibodies after arthroplasty for rheumatic diseases

Migita

Asano

Sato

et al. 2018

FJMS

Self Cite

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Heparin -induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real -world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J -PSVT) designed to document the VTE and seroconversion rates of anti -PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals. J -PSVT indicated that prophylaxis with fondaparinux, not enoxaparin, reduces the risk of deep vein thrombosis in patients undergoing arthroplasty. Multivariate analysis revealed that dynamic mechanical thromboprophylaxis (intermittent plantar device) was an independent risk factor for seroconversion of anti -PF4/heparin antibodies, which was also confirmed by propensity -score matching. Seroconversion rates of anti -PF4/heparin antibodies were significantly reduced in rheumatoid arthritis (RA) patients compared with osteoarthritis (OA) patients, which may link with the findings that IgG fractions isolated from RA patients not OA patients contained PF4. Our study indicated that a unique profile of anti -PF4/heparin antibodies is induced by arthroplasty for rheumatic diseases.

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Effects of a Foot Pump on the Incidence of Deep Vein Thrombosis After Total Knee Arthroplasty in Patients Given Edoxaban

Cited by 20 publications

References 43 publications

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

American Society of Hematology 2019 guidelines for management of venous thromboembolism: prevention of venous thromboembolism in surgical hospitalized patients

Prophylaxis of Venous Thromboembolism in Knee Replacement Surgery

Induction of anti-PF4/heparin antibodies after arthroplasty for rheumatic diseases

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