Effects of a Nanocomplex Containing Antioxidant, Lipid, and Amino Acid on Thermal Burn Wound Surface

Naumov, Andreas; Shatalin, Yu. V.; Potselueva, M. M.

doi:10.1007/s10517-010-0876-5

Cited by 11 publications

(3 citation statements)

References 3 publications

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“…Encapsulation of these drugs into nanoemulsions facilitates their penetration into the skin layers and provides a dispersed oil droplet phase to improve their solubility. [111][112][113] Nanohydrogels are a group of nanostructures for wound dressing that offer discrete advantages of high flexibility, high hydrophilicity, high mechanical strength, tunable structure, and the ability to absorb wound exudates as well as permeate oxygen and prevent wound dehydration. 114,115 Due to their porous structure, they can be considered as another promising nanostructure for providing a sustained and controlled delivery system to the wound.…”

Section: Incorporation Of Natural Products In Different Forms Of Nanomentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

178

113

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Wound healing process is an intricate sequence of well-orchestrated biochemical and cellular phenomena to restore the integrity of the skin and subcutaneous tissue. Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products. Here, we present a review of the efficacy of the plant based-nanomaterials in the management of wounds and discuss the involved therapeutic targets. For this purpose, a profound search has been conducted on in vitro, in vivo, and/or clinical evidences evaluating the efficacy and pharmacological mechanisms of natural product-based nanostructures on different types of wounds. Different pharmacological targets are involved in the wound healing effects of herbal-based nanostructures, including suppressing the production of inflammatory cytokines and inflammatory transduction cascades, reducing oxidative factors and enhancing antioxidative enzymes, and promoting neovascularization and angiogenic pathways through increasing the expression of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor. Moreover, nanostructure of plant extracts and their phytochemicals can enhance their bioavailability, control their release in the form of sustained delivery systems to the wound site, and enhance the permeability of these therapeutics to the underlying skin layers, which are all necessary for the healing process. Overall, various plant extracts and their natural compounds, used in nanoformulations, have demonstrated high activity in the management of wounds and thus can be assumed as future pharmaceutical drugs.

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Section: Incorporation Of Natural Products In Different Forms Of Nanomentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

178

113

View full text Add to dashboard Cite

show abstract

“…These bilayers can be produced from cholesterol and naturally occurring phospholipids including phosphatidylcholine [199]. One study reported that dihydroquercetin formulated as a liposomal nanocomplex could improve endogenous antioxidant activity, reduce the necrotic area in burned skin, and finally induce better healing [200]. Elsewhere, the use of other liposomal components e.g.…”

Section: Nanotechnology For Treatment Of Burn Infections and Woundmentioning

confidence: 99%

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Jahromi

Zangabad

Basri

et al. 2018

Advanced Drug Delivery Reviews

408

189

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According to the latest report from the World Health Organization, an estimated 265,000 deaths still occur every year as a direct result of burn injuries. A widespread range of these deaths induced by burn wound happens in low- and middle-income countries, where survivors face a lifetime of morbidity. Most of the deaths occur due to infections when a high percentage of the external regions of the body area is affected. Microbial nutrient availability, skin barrier disruption, and vascular supply destruction in burn injuries as well as systemic immunosuppression are important parameters that cause burns to be susceptible to infections. Topical antimicrobials and dressings are generally employed to inhibit burn infections followed by a burn wound therapy, because systemic antibiotics have problems in reaching the infected site, coupled with increasing microbial drug resistance. Nanotechnology has provided a range of molecular designed nanostructures (NS) that can be used in both therapeutic and diagnostic applications in burns. These NSs can be divided into organic and non-organic (such as polymeric nanoparticles (NPs) and silver NPs, respectively), and many have been designed to display multifunctional activity. The present review covers the physiology of skin, burn classification, burn wound pathogenesis, animal models of burn wound infection, and various topical therapeutic approaches designed to combat infection and stimulate healing. These include biological based approaches (e.g. immune-based antimicrobial molecules, therapeutic microorganisms, antimicrobial agents, etc.), antimicrobial photo- and ultrasound-therapy, as well as nanotechnology-based wound healing approaches as a revolutionizing area. Thus, we focus on organic and non-organic NSs designed to deliver growth factors to burned skin, and scaffolds, dressings, etc. for exogenous stem cells to aid skin regeneration. Eventually, recent breakthroughs and technologies with substantial potentials in tissue regeneration and skin wound therapy (that are as the basis of burn wound therapies) are briefly taken into consideration including 3D-printing, cell-imprinted substrates, nano-architectured surfaces, and novel gene-editing tools such as CRISPR-Cas.

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“…In this process, the initial burn wound propagates and its propagation can be, for practical purposes, traced by the relatively stable byproducts of lipid peroxidation . Such propagation may terminate under a number of conditions resulting in neutralization of ROS . This may happen when lipid‐phase antioxidant molecules intercept and terminate lipid peroxidation.…”

mentioning

confidence: 99%

Propagation of cutaneous thermal injury: A mathematical model

Xue

Chou

Kao

et al. 2011

Wound Repair Regeneration

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Cutaneous burn wounds represent a significant public health problem with 500,000 patients per year in the U.S. seeking medical attention. Immediately after skin burn injury, the volume of the wound burn expands due to a cascade of chemical reactions, including lipid peroxidation chain reactions. Based on these chemical reactions, the present paper develops for the first time a three-dimensional mathematical model to quantify the propagation of tissue damage within 12 hours post initial burn. We use the model to investigate the effect of supplemental antioxidant vitamin E for stopping the propagation. We show, for example, that if the production rate of vitamin E is increased, post burn, by five times the natural production in a healthy tissue, then this would slow down the lipid peroxide propagation by at least 50%. Our model is formulated in terms of differential equations, and sensitivity analysis is performed on the parameters to ensure the robustness of the results.

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Effects of a Nanocomplex Containing Antioxidant, Lipid, and Amino Acid on Thermal Burn Wound Surface

Cited by 11 publications

References 3 publications

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing

Propagation of cutaneous thermal injury: A mathematical model

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