Effects of a Putty‐Form Hydroxyapatite Matrix Combined With the Synthetic Cell‐Binding Peptide P‐15 on Alveolar Ridge Preservation

Neiva, Rodrigo; Tsao, Yi Pin; Eber, Robert; Shotwell, Jeffrey L.; Billy, Edward J.; Wang, Horn Lay

doi:10.1902/jop.2008.070038

Cited by 65 publications

(88 citation statements)

References 46 publications

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“…It has also been implemented in endodontic surgeries as a concomitant treatment during management of the endodontic-periodontal lesions (1)(2)(3)(4)(5)(6)(7). The function of GTR is to place a barrier membrane over the denuded root surfaces and the debrided periodontal defect to exclude epithelial growth and to allow specifically periodontal ligament and alveolar bone cells to repopulate the isolated space (8,9).…”

mentioning

confidence: 99%

Preclinical Experiments on the Release Behavior of Biodegradable Nanofibrous Multipharmaceutical Membranes in a Model of Four-Wall Intrabony Defect

Chen

Lee

Liao

et al. 2013

Antimicrob Agents Chemother

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e Guided tissue regeneration (GTR) therapy has been widely used to regenerate lost periodontium from periodontal disease. However, in terms of regenerative periodontal therapy, a multidrug-loaded biodegradable carrier can be even more promising in dealing with periodontal disease. In the current study, we fabricated biodegradable nanofibrous collagen membranes that were loaded with amoxicillin, metronidazole, and lidocaine by an electrospinning technique. The in vitro release behavior and the cytotoxicity of the membranes were investigated. A four-wall intrabony defect was created in rabbits for in vivo release analysis. The bioactivity of the released antibiotics was also examined. The experimental results showed that the drug-loaded collagen membranes could provide sustainable release of effective amoxicillin, metronidazole, and lidocaine for 28, 56, and 8 days, respectively, in vivo. Furthermore, the bioactivity of the released antibiotics remained high, with average bioactivities of 50.5% for amoxicillin against Staphylococcus aureus and 58.6% for metronidazole against Escherichia coli. The biodegradable nanofibrous multipharmaceutical membranes developed in this study may provide a promising solution for regenerative periodontal therapy.

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mentioning

confidence: 99%

Preclinical Experiments on the Release Behavior of Biodegradable Nanofibrous Multipharmaceutical Membranes in a Model of Four-Wall Intrabony Defect

Chen

Lee

Liao

et al. 2013

Antimicrob Agents Chemother

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“…Theoretical data was confirmed by clinical outcome (22). In fact, according to several studies (23)(24)(25)(26), new generation hydroxya- (27). Moreover, the osseointegration period was confirmed to range between 9 and 18 months.…”

Section: Discussionmentioning

confidence: 65%

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

Figliuzzi

Giudice

Pileggi

et al. 2016

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SummaryAim. Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used as osteoconductive biomaterial in the treatment of periodontal bone defects. Clinical and radiological evaluations were conducted at 6, 12 and 18 months after the surgery. Materials and methods. Forty patients with 2-and 3-wall intrabony pockets were enrolled in this study. PPD, CAL, radiographic depth (RD) and angular defects were preoperatively measured. After surgery, patients were re-evaluated every 6 months for 18 months. Statistical analyses were also performed to investigate any differences between preoperative and postoperative measurements. Results. Paired t-test samples conducted on the data obtained at baseline and 18 months after, showed significant (p<0.01) differences in each measurement performed. The role of preoperative RD was demonstrated to be a significant key factor (p<0.01). A relevant correlation between preoperative PPD and CAL gain was also found. Conclusions.Within the limitations of this study, the absence of anatomical variables, except the morphology of the bone defect, emphasizes the importance of the proper surgical approach and the graft material used.

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“…Nine months after tooth extraction, they reported no reduction in ridge height and no change in ridge width. Neiva et al (2008) in a 24 patient study over 4 months compared an anorganic bovine-derived hydroxyapatite matrix combined with a synthetic P-15 Putty (PepGen P-15 Putty®) and a bioabsorbable collagen wound dressing (CollaPlug®) to a bioabsorbable wound dressing alone. Neiva reported a loss of 1.31 mm in ridge width and a gain of 0.15 mm in ridge height for the Putty PIS group.…”

Section: Human Extraction Socket Healing Sequencementioning

confidence: 99%

“…Zitzmann et al (1997Zitzmann et al ( ,2001) reported similar results, in a 6-month study of 6 sockets grafted with BioOss®, 27% vital bone, 30% non-vital bone, and 43% trabecular space. Neiva et al (2008), in a 24 patient study, compared a putty-form anorganic bovine-derived hydroxyapatite matrix combined with a synthetic cell-binding peptide P-I5 (Putty PI5) to a bioabsorbable collagen membrane to a bioabsorbable collagen dressing alone. He reported that the Putty PI5 had 29.92% vital bone, 65.25% bone marrow and 6.25% non-viable bone.…”

Section: Xenograft Studiesmentioning

confidence: 99%

Ridge preservation comparing the clinical and histologic healing of a mineralized cortical vs. mineralized cancellous allograft with an acellular dermal matrix barrier membrane.

Sams¹

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Effects of a Putty‐Form Hydroxyapatite Matrix Combined With the Synthetic Cell‐Binding Peptide P‐15 on Alveolar Ridge Preservation

Abstract: A favorable response was observed when Putty P15 was applied to extraction sockets, suggesting that it may be useful for alveolar ridge preservation prior to dental implant placement.

Cited by 65 publications

References 46 publications

Preclinical Experiments on the Release Behavior of Biodegradable Nanofibrous Multipharmaceutical Membranes in a Model of Four-Wall Intrabony Defect

Preclinical Experiments on the Release Behavior of Biodegradable Nanofibrous Multipharmaceutical Membranes in a Model of Four-Wall Intrabony Defect

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

Ridge preservation comparing the clinical and histologic healing of a mineralized cortical vs. mineralized cancellous allograft with an acellular dermal matrix barrier membrane.

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