Effects of a Single Application of Adcon Gel on Peritendinous Adhesion: An Experimental Study in Rabbits

Abstract

Peritendinous adhesions are serious complications after surgical repair of tendons and can lead to poor functional outcome. In the present study, the tensile strength of repaired tendons was measured biomechanically in two groups using a rabbit Achilles tendon model, and the effects of Adcon gel on peritendinous adhesions and tendon healing were examined by means of histological and mechanical analyses. In the treatment group, the Achilles tendon was transected, followed by a primary repair using a modified Kessler technique, and Adcon gel was injected between the tendon and skin of the right leg. The same operation was done for the control group, and 1 mL of normal saline solution was applied locally in a similar fashion. The experimental protocols were approved by the local animal ethics committee. Microscopic evidence of the formation of adhesions and of inflammation was less in the treatment group than in the control group. There was no significant difference in the tensile load necessary to rupture the repaired tendons between the two groups. Adcon gel reduced the peritendinous adhesions histologically without impairing tendon healing, as determined with mechanical analyses. The use of Adcon gel may provide a simple means of preventing of postoperative peritendinous adhesions, thereby offering a beneficial effect on tendon repair.

Design and In Vivo Testing of Novel Single-Stage Tendon Graft Using Polyurethane Nanocomposite Polymer for Tendon Reconstruction

“…With regards to producing an anti-adhesive barrier to prevent ingrowth of surrounding granulation tissue, numerous biological and non-biological materials are being explored, but only as adjuncts to reduce adhesion formation in simple tendon repairs. 29,[32][33][34] Our pilot study provides the first in vivo evidence of utilising PU nanocomposite tubular graft for pseudo-sheath replacement, and converting an otherwise two-stage flexor tendon reconstruction, that is currently produced via the implantation of silicone rods, into a singlestage procedure. The tubular grafts implanted in the sheep retain the integrity of the polymer sheath, resulting in the synthesis of an intact and functional tendon sheath.…”

Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid

“…Adcon® gel were used in clinical applyings since 1996. And also Adcon® gel is a cost effective agent 20 …”

Battling adhesions: from understanding to prevention

“…Although the formation of recurrent adhesions was not assessed, Hyaloglide® showed a significant improvement in the range of motion and activity [ 97 ]. Adcon®Gel, a porcine gelatine combined with a carbohydrate polymer, is another gel barrier that showed promising results in the rabbit Achilles [ 98 ]. Solid barriers, such as Seprafilm® [ 99 ], Interceed® [ 100 ], Tenoglide® (a collagen-GAG matrix [ 101 ]) and DegraPol (an electro-spun polyester-urethane tube [ 102 ]), have also been assessed for tendons, mostly in preclinical models.…”