Effects of a static magnetic field of either polarity on skin microcirculation

Mayrovitz, Harvey N.; Groseclose, Edye E.

doi:10.1016/j.mvr.2004.11.002

Cited by 46 publications

(39 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4, open squares) did not reduce edema formation to any degree, whereas the 10-mT field (open triangles) significantly reduced the edema by 25-55% at all but the last time point, similarly to the 70-mT field (40 -65%; open circles). These data support published assertions that there exists a "physiological window" of effective magnetic field strengths (21,46). In light of these data, the remaining experiments were conducted utilizing the 70-mT magnet.…”

Section: Smf Application For 2 H Reduces Ca-induced Edemasupporting

confidence: 84%

“…Recent studies have demonstrated that localized SMF application can modulate microvascular tone in skeletal muscle (26) and cutaneous tissue (27,28), whereas global SMF application can modulate both blood pressure (29) and flow (21,46), both suggesting that SMF application may be effective in treating edematous tissue conditions. Clinical investigation of local, chronic SMF treatment on postlipectomy patients revealed significant reduction of edema and pain when applied immediately after surgery (20).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Morris¹,

Skalak²

2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

Section: Smf Application For 2 H Reduces Ca-induced Edemasupporting

confidence: 84%

mentioning

confidence: 99%

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Morris¹,

Skalak²

2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

show abstract

“…10 This observation was in accordance with earlier reports on human skin blood flow and on the lack of vasoconstrictive effects at least at this anatomic site. 24,25 The effect on v RBC may therefore be caused directly by magnetic forces on red blood cells as described by others in vitro. 26 Changes in orientation of red blood cells might result in increased blood viscosity-as also shown in vitro 27 -and might thus affect v RBC and blood flow in vessel segments in vivo.…”

Section: Discussionmentioning

confidence: 85%

Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels

Strieth

Strelczyk²,

Eichhorn³

et al. 2008

Cancer Biology & Therapy

View full text Add to dashboard Cite

Red blood cell flow in striated muscle capillaries is reduced during exposure to strong static magnetic fields (SMFs). Intratumoral microcirculation is characterized by tortuous microvessels with chaotic architecture and by irregular, sluggish blood flow with unstable rheology.It was the aim of this study to analyze SMF exposure effects on tumor microcirculation with regard to interactions of corpuscular blood components with tumor microvessel walls. In vivo fluorescence microscopy was performed in A-Mel-3 tumors growing in dorsal skinfold chamber preparations of Syrian Golden hamsters. SMFs with varying field strength (<600 mT) were generated by changing the distance between a strong NdFeB rod magnet and the tissue region of interest.Short-time exposure above a magnetic flux density of about 150 mT resulted in a significant reduction of red blood cell velocity (v RBC ) and segmental blood flow in tumor microvessels. At the maximum strength of 587 mT, a reversible reduction of v RBC (~40%) and of functional vessel densitiy (~15%) was observed.Prolongation of the exposure time from one minute to up to 3 h resulted in comparable reductions. Microvessel diameters and leukocyte-endothelial cell interactions remained unaffected by SMF exposure. However, in contrast to tumor-free striated muscle controls, exposure at the maximum flux density induced a significant increase in platelet-endothelial cell adherence in a time-dependent manner that was reversible after reducing SMF strength.These reversible changes may have implications for functional measurements of tumor microcirculation by MRI and new therapeutic strategies using strong SMFs.

show abstract

“…For unit conversions, 1000 Gauss = 0.1 T (Tesla)]. The north (N) and south (S) poles were randomly arranged, or studied separately as there were controversial reports that elucidate to have differences or no effects of N and S poles (Joshi et al 2009;Mayrovitz and Groseclose 2005). The magnets were applied to the bottom of the wells with a distance of 0.1-0.3 cm to the cells.…”

Section: Application Of Magnetsmentioning

confidence: 99%

Static magnetic field controls cell cycle in cultured human glioblastoma cells

Kim

Shim

et al. 2016

Cytotechnology

View full text Add to dashboard Cite

Magnetic field has been widely used in clinical diagnostics or for clinical treatment and is an important biomedical technology. Glioblastoma multiforme U87 and U251 are models of a fast growing malignant cancer. We focused on cellular level drafting of these cell lines as a time-dependent effect indicator of static magnetic fields (2000 ± 600 Gauss) by using their fast-growing properties. Cell viability showed a significant decrease (p \ 0.01). The results coincided with the occurrence of apoptotic signals or protein expression of cyclin B1 and cyclin dependent kinase 1 in a non-apoptotic manner. Cdk1 was decreased in proportion to ankyrin G and cyclin B1 (Chi-square test, p = 0.0366). Our findings suggest that static magnetic stimulation creates a specific cytoproliferative pattern, rather than producing randomized growth impairment.

show abstract

Effects of a static magnetic field of either polarity on skin microcirculation

Cited by 46 publications

References 15 publications

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Static magnetic fields induce blood flow decrease and platelet adherence in tumor microvessels

Static magnetic field controls cell cycle in cultured human glioblastoma cells

Contact Info

Product

Resources

About