Effects of a triplex mixture of<i>Peganum harmala, Rhus coriaria</i>, and<i>Urtica dioica</i>aqueous extracts on metabolic and histological parameters in diabetic rats

Gaballu, Fereydoon Abedi; Gaballu, Yousef Abedi; Khyavy, Omid Moazenzade; Mardomi, Alireza; Ghahremanzadeh, Kazem; Shokouhi, Behrooz; Mamandy, Himan

doi:10.3109/13880209.2014.960943

Cited by 33 publications

(19 citation statements)

References 23 publications

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“…In all the tested parameters, the liver functions of the diabetes-induced rats could be significantly improved by thymol and thymol nano polymer. ALT and AST are the important hepatic enzymes due to their levels in serum as the specific and reliable biomarker for liver damages [42,49,50]. In confirmation of our results, it was shown in a paper that thymol 40 mg/kg has been able to significantly reduce ALT and AST in diabetic rats by STZ and help animal health [48].…”

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confidence: 80%

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

et al. 2019

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Objective: The aim of this study was to evaluate the effect of thymol and thymol nano polymer on the blood biochemical parameters and anti-diabetic activity in Streptozotocin (STZ)-induced diabetic rats. Methods: The synthesized nano polymer (NP) was characterized by using different spectroscopy methods, such as IR, HNMR and CNMR. Loading and releasing of thymol were investigated by HPLC. Eleven groups of the Streptozotocin-induced diabetic and normal rats (overall 110 males) were tested through various biochemical factors such as: serum glucose, insulin, liver function-related enzymes including ALT, AST, ALP and bilirubin by ELISA kit methods. Results: It has shown that thymol nano polymer is desirable for transferring drug. The amount of thymol loaded on NP estimated at 43±2.5 %. Then, 65% of the loaded drug was released. LD50 for thymol and thymol nano polymer were 435 and 583 mg/kg, respectively. thymol nano polymer at doses of 30, 60 and 90 mg/kg, in a dose-dependent manner, reduced blood glucose, increased insulin levels, and controlled liver enzymes ALT, AST, ALP and bilirubin in the STZ-induced diabetic rats. Conclusion: The use of thymol nano polymer appears to be a new aspect concerning to protect diabetes-induced damage in the animal model.

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confidence: 80%

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

et al. 2019

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“…The samples of liver and kidney tissues were histologically measured by hematoxylin and eosin (H&E) staining. The kidney specimens were assessed for the space and interstitial inflammation, while piecemeal necrosis, focal lytic necrosis, and degree of portal inflammation have been considered based on previously reports (Ishak index protocol) for liver tissue samples [2,18,19]. All histopathological examinations were carried out in the Danesh Pathobiology Laboratory.…”

Section: Histopathological Measurementmentioning

confidence: 99%

“…Diabetic diseases are one of the most common metabolic disorders across the world and more than 220 million people are suffering from their side effects [1]. Generally, two main factors are respon-sible for the causes of diabetic disorders: (1) poor insulin secretion (2) insulin resistance or both of them at the same time [2]. As previous reports, three types of diabetes have high level prevalence in the world including type I, type II and gestational [3].…”

Section: Introductionmentioning

confidence: 99%

In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

et al. 2018

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“…Additionally, after four weeks of treatment with the combined extracts mixture, alanine aminotransferase (ALT), LDL−C, TG, and creatinine recovered to healthy control levels. Moreover, these beneficial effects were more potent with the combination of them compared with that of single treatments …”

Section: Bioactivity Studiesmentioning

confidence: 99%

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Elagbar

Shakya

Barhoumi

et al. 2020

Chemistry & Biodiversity

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Rhus coriaria L. (Anacardiaceae), sumac, is a common condiment, appetizer and souring agent in the Mediterranean region that has a long history in traditional medicine. R. coriaria has been prescribed for the treatment of many ailments including diarrhea, ulcer, hemorrhoids, hemorrhage, wound healing, hematemesis, and eye ailments like ophthalmia and conjunctivitis. The plant is also used as diuresis, antimicrobial, abortifacient and as a stomach tonic. Sumac is known to be rich in different classes of phytochemicals including tannins, polyphenols, flavonoids, organic acids and essential oils and continues to be a hot topic for extensive research work designed for revealing its phytochemical constituents and evaluating its bioactive properties. This review summarizes the recent phytochemical and diverse bioactivity studies on R. coriaria, especially those concerned with antitumor, antioxidant, hypoglycemic, antimicrobial, and anti-inflammatory studies.

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Effects of a triplex mixture ofPeganum harmala, Rhus coriaria, andUrtica dioicaaqueous extracts on metabolic and histological parameters in diabetic rats

Abstract: This study showed that PH, RC, and UD extracts, especially their combination, had significant antidiabetic, hypolipidemic, and liver and renal damage recovering effects.

Cited by 33 publications

References 23 publications

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

Anti-Diabetic Effect of a Novel Nano Polymer of Thymol in Streptozotocin-Induced Diabetic Wistar Rats

In vivo Evaluation of Anti-Hyperglycemic, Anti-hyperlipidemic and Anti-Oxidant Status of Liver and Kidney of Thymol in STZ-Induced Diabetic Rats

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

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