Effects of access condition on substance use disorder-like phenotypes in male and female rats self-administering MDPV or cocaine
Michelle R. Doyle,
Nina M. Beltran,
Mark S. A. Bushnell
et al.
Abstract:Substance use disorder (SUD) is a heterogeneous disorder, where severity, symptoms, and patterns of substance use vary across individuals. Yet, when rats are allowed to self-administer drugs such as cocaine under short-access conditions, their behavior tends to be well-regulated and homogeneous in nature; though individual differences can emerge when rats are provided long- or intermittent-access to cocaine. In contrast to cocaine, significant individual differences emerge when rats are allowed to self-adminis… Show more
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