Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis

Simonyi, Ágnes; Butnariu, Olimpia; Fletcher, Don L.; Rudeen, P. K.; McCrone, Sue; Petersen, Sandra L.

doi:10.1007/bf02917447

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…Furthermore, cold exposure increases TRH mRNA levels within 1 h if the cold stress is initiated in the afternoon, but not in the morning [37]. Other authors were only able to measure a TRH [32] and a TSH [38] response to cold in the afternoon, failed in rats nonacclimatized to elevated ambient temperatures.…”

Section: Neuroendocrine Regulation Of Coid-lnduced Trh Ortsh Releasementioning

confidence: 99%

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

et al. 1996

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This review focuses on the central regulation of thermoregulatory responses with special attention to the participation of thyrotropin-releasing hormone (TRH) in both autonomous and endocrine responses to a cold environment. Besides a direct projection of TRH neurons from paraventricular nuclei (PVN) to the median eminence, and the subsequent activation of the thyroid axis, there are direct projections from the PVN to the autonomic preganglionic neurons controlling autonomous responses. These projections convey information to peripheral targets involved in thermogenesis through the dorsal vagal complex and the spinal cord, for parasympathetic and sympathetic neurotransmissions respectively. Furthermore, cold exposure increases TRH mRNA levels in the PVN but also in dorsal motor and caudal raphe nuclei, thus providing strong evidence for a functional link between autonomous and neuroendocrine systems involved in thermoregulation.

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Section: Neuroendocrine Regulation Of Coid-lnduced Trh Ortsh Releasementioning

confidence: 99%

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

et al. 1996

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“…Acute administration of some drugs alters Trh expression and these changes do not always coincide with changes in TSH or TH serum concentrations (Table 1). Although ethanol increases Trh mRNA levels in the PVN, it blocks increases induced by cold-exposure (Zoeller et al 1995). Cold increases Trh mRNA expression independent of high-TH serum levels (Zoeller et al 1990), but a mild stress 2 h before being submitted to cold suppresses the expected increase in Trh mRNA levels in the PVN but not in serum TSH in male rats (Uribe et al 2011).…”

Section: Hpt Responses To Acute Stimulimentioning

confidence: 99%

“…The changes in Trh mRNA are transient, with increases at 1 h and normalizing by 2 h, even when animals are kept in the cold for long periods; Trh mRNA levels rise again at 6 h but only if animals are exposed during the light period (Uribe et al 1993, Zoeller et al 1995. Acute administration of some drugs alters Trh expression and these changes do not always coincide with changes in TSH or TH serum concentrations (Table 1).…”

Section: Hpt Responses To Acute Stimulimentioning

confidence: 99%

Regulation of TRH neurons and energy homeostasis-related signals under stress

Joseph‐Bravo

Jaimes-Hoy

Charlí

2015

Journal of Endocrinology

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Energy homeostasis relies on a concerted response of the nervous and endocrine systems to signals evoked by intake, storage, and expenditure of fuels. Glucocorticoids (GCs) and thyroid hormones are involved in meeting immediate energy demands, thus placing the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-adrenal axes at a central interface. This review describes the mode of regulation of hypophysiotropic TRHergic neurons and the evidence supporting the concept that they act as metabolic integrators. Emphasis has been be placed on i) the effects of GCs on the modulation of transcription of Trh in vivo and in vitro, ii) the physiological and molecular mechanisms by which acute or chronic situations of stress and energy demands affect the activity of TRHergic neurons and the HPT axis, and iii) the less explored role of non-hypophysiotropic hypothalamic TRH neurons. The partial evidence gathered so far is indicative of a contrasting involvement of distinct TRH cell types, manifested through variability in cellular phenotype and physiology, including rapid responses to energy demands for thermogenesis or physical activity and nutritional status that may be modified according to stress history.

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“…In vitro transcription was performed using linearized plasmid and 35 S-UTP (NEN), according to Zoeller et al (1995) with some modifications. Following removal of the template with RNase-free DNase, the RNA was phenol/chloroform extracted, ethanol precipitated, resuspended in RNase-free water to around 100 ng/µl and stored at -80°C.…”

Section: In Vitro Synthesis Of Rnasmentioning

confidence: 99%

Post-transcriptional regulation of gene expression during the programmed death of insect skeletal muscle

Cascone

Schwartz

2001

Dev Genes Evol

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While considerable attention has focused on the role of specific proteins in mediating programmed cell death, few studies have examined the possible involvement of post-transcriptional regulation of mRNAs associated with this developmental process. We have examined developmental changes in transcript stability and translatability using protein extracts generated from the intersegmental muscles (ISM) of the moth Manduca sexta as a cell-free model system to examine three genes that are representative of the patterns of expression observed in condemned ISMs: repressed (actin), induced (polyubiquitin) and constitutively expressed (ubiquitin-fusion 80; ubf80). In addition, we have used luciferase mRNA as a generic reporter transcript to determine if there are sequence-specific controls of mRNA function related to programmed cell death. Among the three Manduca transcripts, polyubiquitin displayed the shortest half-life (t1/2) in all ISM extracts tested. The stability and translatability of all mRNAs were most affected in extracts from muscle cells from day 17 animals, just prior to the commitment of the muscles to die. Transfer of the 3' untranslated regions from the Manduca transcripts to luciferase mRNA did not appreciably change the stability or translatability of this test transcript. These data suggest that there may be global removal of cellular transcripts just prior to death to allow newly expressed mRNAs to rapidly accumulate to high levels. Such changes in message abundance, translatability and stability may facilitate the efficient activation of death (and perhaps other differentiation programs) in some developmental systems.

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Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis

Cited by 15 publications

References 48 publications

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

Neuroendocrine and Autonomous Mechanisms Underlying Thermoregulation in Cold Environment

Regulation of TRH neurons and energy homeostasis-related signals under stress

Post-transcriptional regulation of gene expression during the programmed death of insect skeletal muscle

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