Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Fan, Arthur Yin; Lao, Lixing; Zhang, R.X.; Zhou, Ang; WANG, Longsheng; Moudgil, Kamal D.; Lee, D.Y.W.; Ma, Zhigui; Zhang, W.Y.; Berman, Brian M.

doi:10.1016/j.jep.2005.03.033

Cited by 77 publications

(49 citation statements)

References 29 publications

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“…might be due present of active analgesic principles acting both centrally and peripherally (Sulaiman et al, 2008). AA is very similar to human RA both in pathological and serological changes, including the involvement of inflammatory mediators in the arthritic etiology (Qin et al, 2008;Fan et al, 2005). In this study, we found that all rats swelled and appeared red in the injected ankle on the 2 nd day after FCA injection.…”

Section: Membrane Stabilizing Activitysupporting

confidence: 62%

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

Tatiya¹,

Saluja²

2011

Rev. bras. farmacogn.

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Machilus macrantha Nees, Lauraceae, bark is traditionally used in the treatment of asthma, tuberculosis and rheumatoid arthritis. In order to validate, mechanism based anti-inflammatory activity of fractions M. macrantha bark are investigated for first time. Test materials viz. petroleum ether (PE), alkaloidal fraction (CH), acetone extracts (TAN) and mucilage (MM) (250 and 500 mg/kg, p.o.) obtained from M. macrantha bark were tested for membrane stabilizing, antinociceptive; anti inflammatory and Freund's complete adjuvant (FCA) induced arthritis activity. Diclofenac sodium and morphine were used as the reference standards in pharmacological assay. Test materials have significantly (p<0.01) inhibited paw edema after Carrageenan and histamine induction at higher doses. Administration of test materials of M. macrantha (250 and 500 mg/kg b.w.) significantly reduced abdominal writhing, formalin nociception, cotton pellet granuloma and vascular permeability in experimental animal. In addition to this, bark of M. macrantha showed chronic anti-rheumatic effect by suppressing the swelling volume, arthritis index, hematological and biochemical parameters (ESR, RA factor, CRP, liver transferase enzyme) in FCA-induced arthritis. It also significantly inhibited protein denaturation, heat-induced haemolysis of RBC and reduction in total leukocyte migration. Bioassay guided fractionation of the pet. ether extract of bark of M. macrantha led to isolation and characterization of β-sitosterol and stigma sterol confirmed by its HPLC, NMR and GC-MS study. In conclusion, extracts of M. macrantha bark can be explored as a therapeutic agent for the treatment of acute and chronic arthritis.

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Section: Membrane Stabilizing Activitysupporting

confidence: 62%

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

Tatiya¹,

Saluja²

2011

Rev. bras. farmacogn.

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“…45,46 The main active ingredients of these gum resins are members of terpenes and terpenoids. 46 -48 Boswellia and oleo gum resins have been evaluated for their in vivo biologic activities through systemic administration.…”

Section: Discussionmentioning

confidence: 99%

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Yuan

An-li

et al. 2006

Cancer

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Accumulating evidence suggests that the androgen receptor (AR) may play an important role in the development and progression of prostate cancer. To find new, useful compounds that effectively may attenuate the function of AR in prostate cancer cells, the authors investigated the effect of gum mastic, a natural resin, on AR activity. An androgen-responsive prostate cancer cell line LNCaP was used as a model for this study. Gene transfer, reverse transcriptase-polymerase chain reaction analysis, electrophoretic mobility shift assay, and Western blot analysis were used to test the effect of gum mastic on the expression and function of the AR. To demonstrate the inhibitory effect of gum mastic on the function of the AR, the expression of androgen-regulated genes, including prostate-specific antigen (PSA), human kallikrein 2 (hK2), and NKX3.1 were measured. In addition, transient transfection assays with the PSA promoter and the AR promoter also were used to test the effects of mastic. The results showed that gum mastic inhibited the expression of the AR at the transcriptional level, resulting in the down-regulation of both AR messenger RNA and protein levels. Therefore, the function of the AR was inhibited, as reflected by the reduced expression of NKX3.1 and PSA and by androgen-stimulated growth. Because gum mastic exhibited a strong in vitro potency to attenuate the expression and function of the AR, further investigation will be required to determine whether this naturally occurring substance has in vivo potency to inhibit prostate cancer development.

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“…An analgesic action has been proven [45]. In addition, an anti-inflammatory effect of B. serrata by suppressing pro-inflammatory mediators has been reported with 12-ursene 2-diketone being the responsible compound [46].…”

Section: Anethum Graveloensmentioning

confidence: 99%

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

Farzaei

Gooshe

et al. 2014

Rheumatol Int

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Osteoarthritis (OA) is a chronic condition in which imbalance between anabolic and catabolic mediators occurs leading to the destruction of homeostasis of articular cartilage. The current drugs in the management of OA can just alleviate symptoms. Hence, the research tendency toward exploration of novel sources has been grown up in order to achieve safe and efficacious drugs. Meanwhile, various components exist as novel natural drugs that may possess favorable properties for the management of OA. This review focuses on the most efficacious medicinal plants and their phytochemical agents, which have been consumed for the management of OA. Moreover, evaluation of their efficacy and molecular mechanisms of action are discussed based on numerous modern experimental investigations. More research is needed to develop therapeutic agents with disease-modifying properties to treat OA.

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Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Cited by 77 publications

References 29 publications

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

Further studies on membrane stabilizing, anti-inflammatory and FCA induced arthritic activity of various fractions of bark of Machilus macrantha in rats

Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells

Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis

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