Effects of Autologous Bone Marrow Cells on Apoptosis and Regeneration of Non-Healing Autoimmune Gastric Ulcers

Аскаров, М. Б.; Vostrikova, O. F.; Vorobjova, N. N.; Onishenko, N. A.

doi:10.1007/s10517-009-0360-2

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Moreover, Askarov et al reported that acceleration of ulcer regeneration by BM-MSCs transplantation was attributed to an increase in the levels of proinflammatory cytokines (IL-10, IL-4, transforming growth factorbeta (TGF-β)) with simultaneous reduction in the expression of apoptosis marker (caspase-9). So, BM-MSCs could regulate the apoptosis activity in the gastric mucosa [29] .…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of adipose derived mesenchymal stem cells in regeneration of gastric ulcer in rats

Kasaby

Ghaly

Zeid

et al. 2017

Journal of Medical Histology

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Background and objectives: Adipose tissue is an abundant and easily accessible tissue for obtaining multipotent stem cells that harbor similar phenotypes to bone marrow mesenchymal stem cells. This study aimed to demonstrate the effect of adiposederived mesenchymal stem cells (AD-MSCs) on repairing the aspirin-induced gastric ulcer (GU). Materials and Methods: The gastric ulcer in rats was induced by oral dose of 100 mg/kg aspirin for 3 days. AD-MSCs isolated from male rats were transplanted into female rats via tail vein injection. Healing of the GU was monitored histologically. Homing of the in vivo administration of MSCs was assessed by PCR detection of SRY gene and immunohistochemical detection of CD44 in gastric mucosa. Results: At 72 hours after AD-MSCs transplantation, there was complete restoration of the fundic glands with marked reduction in inflammatory cellular infiltrate and a significant increase in the mean value of optical density of PAS positive area (P < 0.05). The mean number of CD44 positive cells in the gastric mucosa was significantly increased (P < 0.05). SRY-specific gene of Y chromosome was detected in female rat gastric mucosa. Conclusions: In vivo transplantation of AD-MSCs accelerate healing of GU in a rat model of gastric injury.

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Section: Discussionmentioning

confidence: 99%

Therapeutic potential of adipose derived mesenchymal stem cells in regeneration of gastric ulcer in rats

Kasaby

Ghaly

Zeid

et al. 2017

Journal of Medical Histology

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“…Bone marrow-mesenchymal stem cells (BMMSCs) were reported by multiple studies to have a valuable role in the gut damage healing and contribute to the gastrointestinal tissue's development (Liu et al, 2015). Askarov et al (2008) found that multipotent mesenchymal stromal cells derived from autologous bone marrow may promote gastric mucosa microcirculation, stimulate angiogenesis, and enhance gastric ulcer healing in rats This study aimed to assess 5-FU effect on gastric mucosa and compare between the beneficial regenerative effects of BMMSCs and Astaxanthin on 5-FU-induced gastric toxic lesions.…”

Section: Introduction mentioning

confidence: 99%

Bone Marrow Derived Mesenchymal Stem Cells Versus Astaxanthin in Treatment of Toxic Effect of 5-Fluorouracil on Gastric mucosa of Male Albino Rats

Elshazly

Taha

Sarg

et al. 2023

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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Five-fluorouracil (5-FU) is an effective chemotherapeutic medication. It is commonly implicated in treatment of various malignancies; this research aimed to investigate potential therapeutic effect of the BMMSCs and Astaxanthin on 5-FU toxic effect on albino rat's stomach. 40 rats were divided into 4 groups: Group I (control group): received no treatment Group II (5-fluorouracil group): for 5 consecutive days rats were intravenously injected by 50 mg/kg 5-FU. Group III (5-Fluorouracil group and Astaxanthin): got 5-FU as in group II, followed by astaxanthin 50mg/kg for 10 consecutive days. Group IV (BMMSCs): received 5-FU as in group II then intravenously injected by 10 6 of BMMSCs once in rat tail. All rats were sacrificed on the 35 th day from the beginning of the experiment, to be examined microscopically, stomach sections were stained by H&E to evaluate histopathological changes, stained also with PAS to evaluate mucosal glycoprotein production, transmission electron microscopic was used to evaluate ultra-structural changes and Immunohistochemistry using Ki67 was used to evaluate level of cell proliferation. examination of stomach Sections of group II showed separation in the gastric glands, congested blood capillary, vacuolations of parietal cells, while (Gr III) and (Gr IV) showed marked stomach histological structure improvement and down regulated expression of Ki67, compared to the (GrII). Electron microscope supported these results. Both BMMSCs and Astaxanthin have good impact in ameliorating the toxic effect of 5-FU on albino rats stomach, with no significant difference between both techniques.

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Stem Cell Applications for the Treatment of Gastrointestinal System Diseases

Trébol

Georgiev-Hristov

García‐Arranz³

et al. 2012

Regenerative Medicine and Cell Therapy

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Effects of Autologous Bone Marrow Cells on Apoptosis and Regeneration of Non-Healing Autoimmune Gastric Ulcers

Cited by 5 publications

References 7 publications

Therapeutic potential of adipose derived mesenchymal stem cells in regeneration of gastric ulcer in rats

Therapeutic potential of adipose derived mesenchymal stem cells in regeneration of gastric ulcer in rats

Bone Marrow Derived Mesenchymal Stem Cells Versus Astaxanthin in Treatment of Toxic Effect of 5-Fluorouracil on Gastric mucosa of Male Albino Rats

Stem Cell Applications for the Treatment of Gastrointestinal System Diseases

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