Effects of autologous leukocyte-platelet rich fibrin (L-PRF) on the rate of maxillary canine retraction and various biomarkers in gingival crevicular fluid (GCF): A split mouth randomized controlled trial

Barhate, Uday Hemant; Duggal, Isha; Mangaraj, Manaswani; Sharan, Jitendra; Duggal, Ritu; Jena, Ashok Kumar

doi:10.1016/j.ortho.2022.100681

Cited by 10 publications

(26 citation statements)

References 28 publications

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“…We observed 0.28mm of extra tooth movement over a period of 8-weeks. Similar to our observation, Barhate et al (7) reported 0.35mm extra tooth movement over a period of 8-weeks. However, Tehranchi et al [3] reported 0.38mm of more tooth movement following the L-PRF placement over 16-weeks period.…”

Section: Discussionsupporting

confidence: 92%

“…Recently blood concentrates like PRP and PRF have been used to accelerate OTM. However, studies evaluating the effect of L-PRF on the rate of tooth movement shows contradictory results [3][4][5][6][7]. In the present study, we observed faster canine retraction during rst four weeks following the L-PRF placement showing its bene cial effects on rate of OTM.…”

Section: Discussioncontrasting

confidence: 42%

“…[6] observed decreased rate of canine retraction in young adults following L-PRF application, giving a contradictory opinion. Recently Barhate et al [7] reported very minimum bene cial effect of L-PRF on OTM.…”

Section: Introductionmentioning

confidence: 98%

“…Blood concentrates like platelet-rich plasma (PRP) [1,2] and platelet-rich brin (PRF) [3][4][5][6][7] are currently used to accelerate the orthodontic tooth movement (OTM). The leukocyte-platelet rich brin (L-PRF) has been termed as the second-generation platelet concentrate.…”

Section: Introductionmentioning

confidence: 99%

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Rate of Canine Retraction and Expression of Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG) in Gingival Crevicular Fluid (GCF) Following the Placement of Autologous Leukocyte-Platelet Rich Fibrin (L-PRF) Among Subjects with Class I Bimaxillary Protrusion Malocclusions: A Split-Mouth Randomized Controlled Trial

Balarama

Duggal

Sharan

et al. 2023

Preprint

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Objectives: To assess the outcome of L-PRF on the rate of maxillary canine retraction and its correlation with the levels of RANKL and OPG in the GCF. Subjects and Methods: Eighteen females who required all 1st premolars extraction for the correction of their Class-I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction (T0), then at 1-week (T1), 2-weeks (T2), 4-weeks (T3), and 8-weeks (T4) after the 1st premolars extraction and placement of L-PRF plugs. The concentrations of RANKL and OPG in the GCF were evaluated at T0, T1, T2, T3 and T4. Results: In experimental sides, the amount of canine retraction was statistically more during the T0-T1 (P=0.035), T1-T2 (P=0.001), and T2-T3 (P=0.038) periods. The mean concentration of RANKL at T1 (P=0.001), T2 (P=0.002) and T3 (P=0.010) was significantly more in the experimental sides. The mean concentration of OPG was significantly less in the experimental sides at T2 (P=0.016), T3 (P=0.020) and T4 (P=0.023). The RANKL:OPG was significantly more in the experimental sides at T1 (P=0.002), T2 (P=0.001), T3 (P=0.001) and T4 (P=0.005). No significant correlation found between canine retraction and RANKL and OPG concentrations in GCF. Conclusions: The L-PRF accelerated the rate of maxillary canine retraction by 0.28mm over 8-weeks period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations. Trial registration: The Clinical Trials Registry of India (Reg. No. CTRI/2020/10/028390, Date-13.10.2020).

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 42%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Rate of Canine Retraction and Expression of Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG) in Gingival Crevicular Fluid (GCF) Following the Placement of Autologous Leukocyte-Platelet Rich Fibrin (L-PRF) Among Subjects with Class I Bimaxillary Protrusion Malocclusions: A Split-Mouth Randomized Controlled Trial

Balarama

Duggal

Sharan

et al. 2023

Preprint

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“…To obtain PRF, which will subsequently be injected into the buccal and palate mucosa to quicken orthodontic movement, the yellow-orange section of the animal was employed [81]. Uday H. Barhate et al (2022) evaluated the effect of L-PRF on the rate of canine maxillary retraction [60]. A careful analysis of the study models observed some correlation but is not statistically significant between canine retraction and the concentration of cytokines such as IL-1β and TNF-α.…”

Section: Prp and Prfmentioning

confidence: 99%

Acceleration Techniques for Teeth Movements in Extractive Orthodontic Therapy

Dipalma,

Patano,

Ferrara

et al. 2023

Applied Sciences

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For a world that is constantly trying to speed up every procedure while obtaining the maximum result, traditional orthodontics have the biological limitation of using light and constant forces that allow tooth movement in a time frame that is only sometimes short. The treatment time could be lengthened if surgical procedures are programmed in the plan. Methods to accelerate tooth movement and reduce the duration of treatment while minimising complications are investigated and reported in the dental literature (e.g., low-level laser therapy, corticotomy, and micro-osteoperforations). This systematic review aims to analyse and summarise the strategies for quickening orthodontic movement during extraction orthodontic treatment, including any potential drawbacks or adverse consequences. The review will evaluate each approach’s effectiveness, safety, and evidence quality, compare their benefits and disadvantages, and analyse the implications for clinical practice and future research. Pubmed, Science Direct, Scopus, and Web of Science were searched using the keywords “acceleration” AND “dental movement” AND “orthodontic” between 1 April 2003 and 1 April 2023. After carefully scanning the study findings, forty-four publications were chosen for the systematic review. Most therapies discussed and provided in the literature seem promising and successful in enhancing orthodontic treatments. The success of operations like corticotomies, piezo-incisions, micro-osteoperforations, osteogenic distraction, low-level laser therapy, the administration of pharmacological treatments, and infiltrations with PRF and PRP were statistically significant and appear to be promising and effective in optimising orthodontic treatments. These strategies expedite treatment and enhance the patient experience, potentially broadening orthodontic appeal and minimising issues like cavities and enamel demineralisation. Further studies, with larger samples and standardised treatment protocols, are needed to investigate the efficacy of these tooth movement acceleration modalities.

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Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid

et al. 2023

Self Cite

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Objectives To assess the outcome of leukocyte-platelet-rich fibrin (L-PRF) on the rate of maxillary canine retraction and its correlation with the levels of Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and RANKL:OPG in the gingival crevicular fluid (GCF) during comprehensive orthodontic treatment. Subjects and methods Eighteen females who required all 1st premolars extraction for the correction of their class I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction ( T 0 ) and then at 1 week ( T 1 ), 2 weeks ( T 2 ), 4 weeks ( T 3 ), and 8 weeks ( T 4 ) after the 1st premolar extraction and placement of L-PRF plugs. T he concentrations of RANKL and OPG in the GCF were evaluated at T 0 , T 1 , T 2 , T 3 , and T 4 . Results In experimental sides, the amount of canine retraction was statistically more during the T 0 – T 1 , T 1 – T 2 , and T 2 – T 3 periods. The mean concentration of RANKL at T 1 , T 2 , and T 3 was significantly more in the experimental sides. The mean concentration of OPG was significantly less in the experimental sides at T 2 , T 3 , and T 4 . The RANKL:OPG was significantly more in the experimental sides at T 1 , T 2 , T 3 , and T 4 . No significant correlation was found between amount of canine retraction and concentration of RANKL and OPG and RANKL to OPG ratio in GCF. Conclusions The L-PRF accelerated the rate of maxillary canine retraction by 0.28 mm over an 8-week period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations. There was no significant correlation betw...

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Effects of autologous leukocyte-platelet rich fibrin (L-PRF) on the rate of maxillary canine retraction and various biomarkers in gingival crevicular fluid (GCF): A split mouth randomized controlled trial

Cited by 10 publications

References 28 publications

Acceleration Techniques for Teeth Movements in Extractive Orthodontic Therapy

Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid

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