Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: A rat patellar tendon model

Abstract

(2000) Effects of basic fibroblast growth factor (bFGF) on early stages of tendon healing: A rat patellar tendon model, Acta Orthopaedica Scandinavica, 71:5, 513-518,

What We Should Know Before Using Tissue Engineering Techniques to Repair Injured Tendons: A Developmental Biology Perspective

“…By treating injured rat patellar tendons with FGFs, the healing process was improved due to an increase in cell proliferation and type III collagen expression. 86 Application of FGFs to cruciate ligament injuries in the dog also enhanced the healing process. 87 Moreover, it has been reported that FGF2 expression increased at tendon injury sites in different animal models.…”

“…Several studies have attempted to use biological treatments to repair injured tendons (Table 1). 86,104,106,[108][109][110][111][112][113][114][115][116][117][118][119] However, the efficiency of the restoration from these treatments is unsatisfying. Many potential factors have been implicated in tendon formation, but how they interact and regulate to generate a functional tendon remains to be discovered.…”

Regenerative Medicine for Tendon Regeneration and Repair: The Role of Bioscaffolds and Mechanical Loading

“…The results of in vitro studies have shown that growth factors can promote cell proliferation and protein synthesis (Fu SC et al 2003) (Jann HW et all 1999)Injured tendons treated with growth factors show improved mechanical properties. (Aspenberg P & Forslund C 1999) (Zhang F et al 2003) (Chan BP 2000). Gene therapy in tendon engineering is an attractive new approach to the treatment of tendon lacerations.…”

Efeito do plasma rico em plaquetas na regeneração do terço central do ligamento da patela: estudo prospectivo randomizado

“…A fase proliferativa é caracterizada pela proliferação de fibroblastos e neoangiogênese, fase em que atuam o VEGF, IGF-I e bFGF. Chan et al (31,46) demonstraram aumento na proliferação de fibroblastos com a aplicação de bFGF em ligamentos da patela em coelhos. Na fase de reparação ocorre a produção de matriz extracelular, principalmente colágeno tipos I e III e proteoglicanos.…”

“…Foram relatados in vitro e in vivo efeitos do PRP e fatores de crescimento em tendões e ligamentos, como estimulação da proliferação de fibroblastos por IGF-I, bFGF e PDGF, e síntese de colágeno e matriz extracelular pelo TGF-b (26,(29)(30)(31) , resultando experimentalmente em uma maior regeneração e aumento da resistência e rigidez tecidual (32,33) .…”