Effects of beta blockade with acebutolol on hypertension, hemodynamics, and fluid volume

Dreslinski, Gerald R.; Aristimuno, Gerardo G.; Messerli, Franz H.; Suárez, Daniel; Fröhlich, Edward D.

doi:10.1002/cpt1979265562

Cited by 29 publications

(12 citation statements)

References 8 publications

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“…The haemodynamic effects of AC after chronic administration have also been reported by others [26,27]. In those studies, the hypotensive action of the drug in the long term was accompanied by a decrease in heart rate.…”

Section: Discussionmentioning

confidence: 55%

Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Mostafavi

Lewanczuk

Foster

2000

Biopharm. Drug Dispos.

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Beta-adrenoceptor blocking drugs are widely used as effective antihypertensive and antianginal agents. We have determined the effect of beta-blockade in the rat to ascertain whether there are differences between metoprolol (MET) and acebutolol (AC) with respect to regional blood flow (RBF). Both AC and MET were administered as a single or multiple intravenous (iv) doses in Sprague-Dawley rats. Microspheres labelled with (85)Sr and (141)Ce were used to measure cardiac output (CO) and RBF before and after drug administration. CO and RBF were measured 1 and 10 min after the i.v. administration of AC (30 mg/kg) and MET (10 mg/kg). After acute administration of MET, CO decreased by 65% and 31% after 1 and 10 min measurements, respectively. These values were 54% and 28% for AC as compared with baseline values. After chronic administration of either AC or MET, however, there were no significant reductions in CO as compared with saline. Both MET and AC significantly reduced RBF in most organs either after 1 or 10 min measurements when compared with the baseline values. It is concluded that both AC and MET reduced CO and RBF after acute administration. The CO and RBF however, returned to normal after chronic administration.

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Section: Discussionmentioning

confidence: 55%

Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Mostafavi

Lewanczuk

Foster

2000

Biopharm. Drug Dispos.

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“…However, this is not the only possible expla nation. as a decrease in renal plasma flow has been reported with agents such as acebutolol without a reduc tion in cardiac output [14]. Therefore, an alteration in renal flow regulation seems also involved.…”

Section: Discussionmentioning

confidence: 99%

Renal Hemodynamic Effects of Tertatolol Compared with Those of Propranolol in the Conscious Dog

Laubie

Prost²,

Rochat³

1986

Am J Nephrol

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Experiments were performed in which the effects of two β-blockers, tertatolol [dl-(hydroxy-2’-t-butyl-amino-3’-propyloxy)-8-thiochroman hydrochloride] and propranolol, on mean arterial pressure (MAP), heart rate (HR), and renal function were studied in the conscious sodium-replete dog. In all experiments renal function was evaluated from the effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) assessed respectively by measurement of p-aminohippurate and creatinine clearances. These parameters were measured during two 30-min control periods, after which two further measurements were performed over a similar time period, after intravenous administration of either propranolol (0.5 mg·kg^-1; n = 8) or tertatolol (0.05 mg·kg^-1; n = 8), these two doses being of equivalent β-adrenoceptor antagonist activity. Administration of propranolol and tertatolol did not change MAP but induced a significant and comparable decrease in HR. After propranolol a significant decrease in ERPF was observed, without any change in GFR or sodium excretion. In contrast, administration of tertatolol resulted in no modification of ERPF, a slight but significant increase in GFR, and a significant increase in sodium and potassium excretion. These results suggest that tertatolol and propranolol though acting similarly on systemic parameters have different effects on renal hemodynamics in the conscious dog.

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“…The mechanism involved remains, however, undefined. When given in doses that do not affect systemic hemo dynamics, propranolol [15] or acébutolol [16] produce renal vasoconstriction. (5-blockers such as propranolol and nadolol have different effects on renal function [ 17] although they suppress renin secretion in a similar fash ion [18].…”

Section: Discussionmentioning

confidence: 99%

Tertatolol Preserves Renal Perfusion in Patients with Arterial Hypertension after Head Injury

et al. 1986

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Tertatolol is a noncardioselective β-adrenergic blocking agent without partial agonist activity. Its central and renal hemodynamic effects were compared to those of an equipotent dosage of propranolol in two groups of 10 patients each who developed arterial hypertension and a hyperdynamic circulatory state after head injury. After tertatolol, 5 mg orally, mean arterial blood pressure was unaffected, heart rate decreased by 22% (p < 0.01) and cardiac index by 24% (p < 0.01) while renal blood flow remained unchanged (-5%; not significant) so that the renal fraction of cardiac index was increased by 22% (p < 0.05). After propranolol, 160mg orally, mean arterial blood pressure was not modified, heart rate decreased by 12% (p < 0.01), cardiac index by 16% (p < 0.01) and renal blood flow by 17% (p < 0.01) so that the renal fraction of cardiac index remained unchanged (-3%; not significant). Tertatolol is a potent β-blocking agent comparable to propranolol apart from the fact that it preserves renal perfusion; this peculiar effect is related to a redistribution of the reduced cardiac output to the benefit of the kidney.

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Effects of beta blockade with acebutolol on hypertension, hemodynamics, and fluid volume

Cited by 29 publications

References 8 publications

Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats

Renal Hemodynamic Effects of Tertatolol Compared with Those of Propranolol in the Conscious Dog

Tertatolol Preserves Renal Perfusion in Patients with Arterial Hypertension after Head Injury

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