Effects of Bisphosphonate on Osteocyte Proliferation and Bone Formation in Patients with Diabetic Osteoporosis

Abstract

Background. Bisphosphonate is currently considered one of the drugs for the first-line treatment of osteoporosis because of its ability to inhibit bone resorption, but the molecular mechanism of its effect on osteocyte proliferation and bone formation of diabetic osteoporosis is still unclear. Objective. To confirm the potential effect on of bisphosphonate on osteocyte proliferation and bone formation in patients having diabetic osteoporosis (DO). Methods. Sixty DO patients admitted to our hospital from February 2019 to April 2021 were randomly selected and divided into the bisphosphonate group and the control group. The total incidence, incidence of hip fracture, efficacy, bone mineral density, osteocalcin, pain score, osteocyte proliferation, bone formation index, serum calcium, and phosphorus contents were compared between two groups. Results. The curative effect of bisphosphonic acid group was better than that of control group, and the difference was statistically significant ( P < 0.05 ). Compared with the control group, the bone mineral density and osteocalcin in the bisphosphonic acid group were significantly improved after treatment, and the pain score in the bisphosphonic acid group was significantly lower than that in the control group ( P < 0.05 ). After intervention treatment, the OD and PINP values in the bisphosphonate group were significantly different from those in the control group ( P < 0.05 ). After treatment, the contents of serum calcium and phosphorus in the bisphosphonic acid group were significantly higher than those in the control group ( P < 0.05 ). The incidence of hip fracture, spinal fracture, and other fractures in the bisphosphonic acid group was significantly lower than that in the control group ( P < 0.05 ). Conclusion. The treatment of DO with bisphosphonate is capability of effectively improving bone cell proliferation and bone formation, further alleviating clinical symptoms and promoting the improvement of the disease.

Efficacy and safety of zoledronic acid in the treatment of osteoporosis: A meta-analysis of randomized controlled trials

“…The general information of the included studies is shown in Table 1 . The 22 studies [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] ] had a total of 11,852 participants. The sample size of the studies ranged from 23 to 7718.…”

“…Eight studies [ [21] , [22] , [23] , [24] , 28 , 32 , 34 , 38 ] reported data on P1NP. Since there was statistical heterogeneity among them ( I 2 = 93.1 %, P = 0), a random effects model was used.…”

Trabecular Bone Score (TBS) in Individuals with Type 2 Diabetes Mellitus: An Updated Review

“…The role of TBS as an everyday tool that is meant to follow-up the effects of antiosteoporotic drugs, as seen for DXA-BMD/T-score, is still controversial, but numerous studies addressed this issue; whether TBS is more useful in T2DM patients than BMD is yet to be proven. On the other hand, so far, no ideal drug against diabetes-induced osteoporosis has been found, and typically the management of the diabetic osteoporotic patients is similar to the non-diabetic individuals in addition to a good glycemic control [6,[76][77][78].…”

Retracted: Effects of Bisphosphonate on Osteocyte Proliferation and Bone Formation in Patients with Diabetic Osteoporosis

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”