Effects of body weight reduction on cardio-ankle vascular index (CAVI)

Nagayama, Daiji; Endo, Kei; Ohira, Masahiro; Yamaguchi, Takashi; Ban, Noriko; Kawana, Hidetoshi; Nagumo, Ayako; Saiki, Atsuhito; Oyama, Tomokazu; Miyashita, Yoh; Shirai, Kohji

doi:10.1016/j.orcp.2011.08.154

Cited by 63 publications

(59 citation statements)

References 26 publications

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“…Several studies have reported that, other than age, VF is the strongest predictor of the CAVI 33,34) ; however, the VF values were not associated with the CAVI independent of age and CRF in the present study ( Table 3). Nagayama et al 33) assessed the changes in the CAVI values in obese subjects who enrolled in a weight reduction program and reported that the improvement in the CAVI was mainly explained by a decrease in VF.…”

Section: Resultscontrasting

confidence: 84%

“…Nagayama et al 33) assessed the changes in the CAVI values in obese subjects who enrolled in a weight reduction program and reported that the improvement in the CAVI was mainly explained by a decrease in VF. Ohashi et al 34) also demonstrated that the VF area is associated with the CAVI in middleaged healthy Japanese adults following adjustment for age.…”

Section: Resultsmentioning

confidence: 99%

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Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Tanisawa

Ito

Sun

et al. 2015

JAT

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Aim: This study aimed to examine whether cardiorespiratory fitness (CRF) is associated with arterial stiffening, evaluated using the cardio-ankle vascular index (CAVI), independent of visceral fat (VF) in middle-aged and elderly Japanese men. We also examined whether the relationship between CRF and the CAVI is modified by age and/or hypertension. Methods: The CAVI was determined in 157 Japanese men (age range, 30-79 years), including 96 hypertensive subjects (61.1%). CRF was assessed by measuring the peak oxygen uptake (V 4 O2peak). The subjects were divided into low-and high-CRF groups, and the VF area was assessed using magnetic resonance imaging.

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Section: Resultscontrasting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Tanisawa

Ito

Sun

et al. 2015

JAT

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“…23) In addition, we have reported that improved insulin sensitivity may contribute to the decrease in CAVI. 20,24) In the present study, the change in serum LPL mass was a significant independent predictor of change in CAVI. This result may suggest that sarpogrelate improves arterial stiffness through mitigating insulin sensitivity.…”

Section: Discussionsupporting

confidence: 53%

Sarpogrelate Hydrochloride Decreases Cardio-Ankle Vascular Index Accompanied by Increased Serum Lipoprotein Lipase Mass in Type 2 Diabetic Patients

et al. 2014

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SummaryThe 5-hydroxytryptamine2A receptor antagonist sarpogrelate hydrochloride exerts its effect not only by inhibition of platelet aggregation, but also by some pleiotropic effects. We have reported that a low serum lipoprotein lipase (LPL) mass level reflects insulin resistance and may be a risk factor for atherosclerotic diseases. The aim of this prospective study was to clarify the effect of sarpogrelate on serum LPL mass and cardio-ankle vascular index (CAVI) as a marker related to arterial stiffness.Thirty-five type 2 diabetic patients (21 males and 14 females) with ankle brachial indices higher than 0.90 received sarpogrelate hydrochloride 300 mg/day for 6 months. Serum LPL mass and CAVI were measured during the study.After 6 months of sarpogrelate hydrochloride treatment, CAVI decreased significantly (10.11 ± 0.92 to 9.87 ± 0.97, P < 0.05) and serum LPL mass increased significantly (58.2 ± 17.5 to 63.5 ± 21.4, P < 0.05). A negative correlation between change in CAVI and change in serum LPL mass was observed (r = -0.34, P < 0.05). Multiple regression analysis identified a change in serum LPL mass as a significant independent predictor for change in CAVI.We demonstrated that sarpogrelate hydrochloride decreased CAVI accompanied by increased serum LPL mass in type 2 diabetic patients. This result suggests that sarpogrelate hydrochloride improves arterial stiffness and is a potential treatment for diabetic angiopathy. (Int Heart J 2014; 55: 337-341) Key words: Diabetic angiopathy 5 -Hydroxytryptamine (5-HT) is closely related to the pathogenesis of diabetic angiopathy. Sarpogrelate hydrochloride (sarpogrelate), a selective 5-HT2A receptor antagonist, is used in diabetic patients with chronic arterial occlusive diseases.1) Sarpogrelate suppresses platelet aggregation, vascular endothelial dysfunction, and smooth muscle contraction mediated by 5-HT2A receptors.2,3) Furthermore, the effect of sarpogrelate on modification of adipocyte structure and function has been reported. 4)Recently, cardio-ankle vascular index (CAVI) has been developed as a marker related to arterial stiffness in Japan, which essentially reflects the stiffness of the aorta, femoral artery, and tibial artery. The CAVI is independent of blood pressure (BP) and has adequate reproducibility for clinical use. 5)Furthermore, no special technique is required for the measurement of CAVI. Several reports have demonstrated the usefulness of CAVI for the detection of atherosclerotic diseases. [5][6][7][8][9] However, the effect of sarpogrelate on CAVI is not clear.In this study, we investigated prospectively the effect of sarpogrelate on arterial stiffness assessed by CAVI in type 2 diabetic patients. Furthermore, factors contributing to the change in arterial stiffness were also analyzed.

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“…The reduction of body weight improves CAVI in addition to many risk factors in the patients with metabolic syndrome 43) . Nagayama et al 73) reported that weight reduction using a calorie restriction diet decreased CAVI in obese patients with type 2 diabetes. The change in VFA was a significant independent predictor of the change in CAVI.…”

Section: Treatment Of Obesity and Metabolic Syndromementioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those could be measured simply and non-invasively. PWV had established the usefulness of measuring arterial wall stiffness. However, PWV essentially depends on blood pressure at the time of measurement. Therefore, PWV is not appropriate as a parameter for the evaluation of arterial stiffness, particularly for the studies involving blood pressure changes.On the other hand, stiffness parameter is an index reflecting arterial stiffness without the influence of blood pressure. Recently, this parameter has been applied to develop a new arterial stiffness index called cardio-ankle vascular index (CAVI). Therefore, CAVI does not depend on blood pressure changes during the measurements; CAVI could represent the stiffness of the arterial tree from the origin of the aorta to the ankle.Many clinical studies obtained from CAVI are being accumulated. CAVI showed high value in arteriosclerotic diseases, such as coronary artery diseases, cerebral infarction, and chronic kidney diseases, and also in majority of people with various coronary risk factors. The improvement of those risk factors decreased CAVI. Furthermore, the role of CAVI as a predictor of cardio-vascular events was reported recently.We review the clinical studies on CAVI and discuss the clinical usefulness of CAVI as a candidate surrogate end-point marker for cardiovascular disease.

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Effects of body weight reduction on cardio-ankle vascular index (CAVI)

Cited by 63 publications

References 26 publications

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Cardiorespiratory Fitness is a Strong Predictor of the Cardio-ankle Vascular Index in Hypertensive Middle-aged and Elderly Japanese Men

Sarpogrelate Hydrochloride Decreases Cardio-Ankle Vascular Index Accompanied by Increased Serum Lipoprotein Lipase Mass in Type 2 Diabetic Patients

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

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