Effects of Bread Yeast Cell Wall Beta-Glucans on Mice with Loperamide-Induced Constipation

Chen, Zhuoyi; Lin, Susu; Jiang, Yu; Liu, Ling; Jiang, Jingjing; Chen, Shuting; Tong, Yingpeng; Wang, Ping

doi:10.1089/jmf.2019.4407

Cited by 26 publications

(17 citation statements)

References 50 publications

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“…Chen et al . [ 93 ] used the β-glucan extracted from bread yeast cells to treat loperamide-induced constipated mice and found enhanced intestinal motility. The pharmacological effect of β-glucan may be mediated by the enhanced expression of epithelial tight junction proteins (zonula occludens-1 and mucin-2) and neurotransmitters (acetylcholinesterase and serotonin).…”

Section: Introductionmentioning

confidence: 99%

Role of gut microbiota in functional constipation

Zhang

Wang

et al. 2021

Gastroenterology Report

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Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence suggests an association between FC and abnormal gut microbiota. The relationship between the gut microbiota and the gut transit is likely bidirectional. This review summarizes the current evidence regarding the impact of gut microbiota on the pathogenesis of FC. By modulating the colonic motility, secretion, and absorption, gut microbiota may contribute to the development of FC through microbial metabolic activities involving bile acids, short-chain fatty acids, 5-hydroxytryptamine, and methane. In support of the key roles of the gut microbiota in FC, treatment with probiotics, prebiotics, synbiotics, and traditional Chinese medicine often result in compositional and functional changes in the gut microbiota. Further studies on the pathogenesis of FC and the therapeutic mechanism of microecological agents will provide a knowledge base for better management of FC.

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Section: Introductionmentioning

confidence: 99%

Role of gut microbiota in functional constipation

Zhang

Wang

et al. 2021

Gastroenterology Report

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“…β-glucan improves the intestinal barrier mechanism and maintains the mucous membrane integrity by promoting the development of neurotransmitters involving close-linked protein, serotonin substance P, and acetylcholinesterase in the intestinal epithelium [ 45 ]. In addition, it improves the gastrointestinal tract’s ability through the development of intestinal peristalsis motility and promotes the diversity and richness of the intestinal microbiota using intestinal bacteria for fermentation [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of 1,3-Beta Glucans Dietary Addition on the Growth, Intestinal Histology, Blood Biochemical Parameters, Immune Response, and Immune Expression of CD3 and CD20 in Broiler Chickens

Amer

Attia

Aljahmany

et al. 2022

Animals

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This experiment evaluated the impact of the dietary addition of 1,3-β-glucans (GLU) on broiler chickens’ growth, intestinal histology, blood biochemical parameters, and immunity. Two hundred three-day-old male broilers (Ross 308) (97.93 ± 0.19 g/chick) were randomly assigned into four treatments with five replicates, each containing ten birds, in a complete randomized design. The four treatments were formulated with 0, 50, 100, and 150 mg 1,3-β-glucans kg−1 in broiler chicken diets. During the study, no significant impacts (p > 0.05) were observed in weight gain and feed conversion ratio (FCR) between treatment groups. Based on the results of total body weight gain and FCR, the optimal level of 1,3-β-glucan is 120 mg Kg−1. The intestinal histomorphology was improved by GLU supplementation, as indicated by increased villi height and villi height to crypt depth ratio (p < 0.01). All levels of supplemental β-1,3 glucan decreased the serum total cholesterol (TC), triglyceride levels, and low-density lipoprotein cholesterol (LDL-C) (p < 0.05). The serum levels of growth hormones (GH), triiodothyronine (T3), and thyroxine (T4) were increased in GLU-supplemented groups (p < 0.05). The serum immune indices (lysozyme activity, interleukin 10 (IL10), complement 3 (C3), and total protein levels) were increased in the GLU-supplemented groups (p < 0.05). Dietary GLU up-regulated the immunoexpression of CD3 (T-cell marker) and CD20 (B-cell marker) in the spleen of birds (p < 0.01). It can be concluded that 1,3-β-glucan can be added to broiler chicken diets for improving the development and integrity of the intestine and enhancing the bird’s immune status. The optimal level for 1,3-β-glucan dietary supplementation was 120 mg Kg−1. Dietary 1,3-β-glucan has a hypolipidemic effect and improves the hormonal profile of birds without affecting their growth rate.

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“…3 ), which is a central feature of this constipation model [ 20 , 36 ]. Several studies have also shown that treatment with Lop reduced the expression of colonic MUC2 at mRNA [ 37 , 38 ] and protein levels [ 39 ]. However, the effect of Lop treatment on the expression of MUC2 cannot be observed in this study (Fig.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice

Chen¹,

Wu²,

Huang³

et al. 2021

Probiotics & Antimicro. Prot.

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Lactobacillus plantarum PS128 has been reported as a psychobiotic to improve mental health through the gut–brain axis in experimental animal models. To explore its mechanism of action in the gut, this study aimed to analyze the effects of L. plantarum PS128 ingestion on naïve and loperamide (Lop)-induced constipation mice. We found that, in the two mouse models, the weight, number, and water content of feces in the L. plantarum PS128 group were higher than those in the vehicle control group. Histological observation revealed that L. plantarum PS128 increased the level of colonic mucins including the major mucin MUC2. In addition, the charcoal meal test showed that L. plantarum PS128 significantly increased the small intestine transit in naïve mice, but not in the Lop-treated mice. Since intestinal serotonin has been found to modulate motility, we further analyzed the expression of genes related to serotonin signal transduction in the small intestine of naïve mice. The results showed that L. plantarum PS128 significantly altered the expression levels of Tph1, Chga, Slc6a4, and Htr4, but did not affect the expression levels of Tph2, Htr3a, and Maoa. Furthermore, immunohistochemistry revealed that L. plantarum PS128 significantly increased the number of serotonin-containing intestinal cells in mice. Taken together, our results suggest that L. plantarum PS128 could promote intestinal motility, mucin production, and serotonin signal transduction, leading to a laxative effect in mice.

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Effects of Bread Yeast Cell Wall Beta-Glucans on Mice with Loperamide-Induced Constipation

Cited by 26 publications

References 50 publications

Role of gut microbiota in functional constipation

Role of gut microbiota in functional constipation

Effect of 1,3-Beta Glucans Dietary Addition on the Growth, Intestinal Histology, Blood Biochemical Parameters, Immune Response, and Immune Expression of CD3 and CD20 in Broiler Chickens

Lactobacillus plantarum PS128 Promotes Intestinal Motility, Mucin Production, and Serotonin Signaling in Mice

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