Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice

Chen, S.-M.; Sato, Noriko; Yoshida, Masatake; Satoh, Nobunori; Ueda, Shiro

doi:10.1016/j.jep.2007.11.026

Cited by 22 publications

(19 citation statements)

References 17 publications

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“…Although the biological activity of certain Bupleurum essential oils and saponins had been compiled early in 2006, [10] a vast body of scientific literature on the pharmacological activity of other species and classes of secondary metabolites have since emerged. [63,[66][67][68][69][70][71][72][73][74] A summary of some of the relevant literature is given in Table 1 and discussed in the following section.…”

Section: Pharmacological Properties Of Bupleurummentioning

confidence: 99%

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2011

Journal of Pharmacy and Pharmacology

229

161

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Objectives Radix Bupleuri represents one of the most successful and widely used herbal drugs in Asia for treatment of many diseases over the past 2000 years. Thorough studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. In this work, we review the chemistry and pharmacology of the genus Bupleurum and explore the relationships between the pharmacological effects and the chemical composition of these drugs. Key findings Early studies on the genus Bupleurum had focused only on the traditional uses of the plants in the treatment of inflammatory disorders and infectious diseases. After chemical profiling, several groups of secondary metabolites were characterized with relevant biological activity: triterpene saponins (saikosaponins), lignans, essential oils and polysaccharides. As a result, present interest is now focused on the bioactivity of the isolated triterpene saponins acting as immunomodulatory, anti-inflammatory and antiviral agents, as well as on the observed ant-iulcer activity of the polysaccharides and anti-proliferative activity of different lignans. Many saikosaponins exhibited very potent anti-inflammatory, hepatoprotective and immunomodulatory activities both in vivo and in vitro. Conclusions Further investigations and screenings are required to explore other Bupleurum species, to evaluate the clinical safety and possible interactions with other drugs or herbs. Standardization of Bupleuri extracts is crucial for them being integrated into conventional medicine due to large chemical and biological variations between different species and varieties.

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Section: Pharmacological Properties Of Bupleurummentioning

confidence: 99%

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2011

Journal of Pharmacy and Pharmacology

229

161

View full text Add to dashboard Cite

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“…Pharmacological study showed that it had the effect of anti-inflammatory (S.M. Chen et al, 2008), antiviral activities (Chiang, 2003), antioxidant and hepatoprotective effect (B.J. Wang et al, 2004) etc.…”

Section: Study Of Liver Meridian Guide Drug: Vinegar-baked Bupleuriradixmentioning

confidence: 99%

Targeting Effect of Traditional Chinese Medicine

Zhao¹

2012

Recent Advances in Theories and Practice of Chinese Medicine

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“…Saikosaponins, the major bioactive ingredients of the genus Bupleurum with a long history of medicinal use, exert significant pharmacological activities, including antitumor (targeting various cancer cells) (Motoo and Sawabu, 1994;Ahn et al, 1998;Hsu et al, 2000;Tsai et al, 2002;Wen-Sheng, 2003;Hsu et al, 2004;Kim and Hong, 2011), chemosensitizing (Wang et al, 2010a), anti-inflammatory (Yokoyama et al, 1981;Nose et al, 1989a;Bermejo Benito et al, 1998), immunomodulatory (Kumazawa et al, 1989;Leung et al, 2005;Sun et al, 2009), hepatoprotective (Abe et al, 1980;Fan et al, 2007;Wu et al, 2008), antinephritic Chen et al, 2008;Hattori et al, 2008), antibacterial and antiviral (Kumazawa et al, 1990;Chiang et al, 2003;Cheng et al, 2006), estrogenic (Wang et al, 2010b), and promoting amylase secretion in rat pancreatic acini (Yu et al, 2002). On the other hand, saikosaponins have also been reported to be responsible for toxicity induced by their hemolytic action (Abe et al, 1978a, b;Nose et al, 1989b).…”

Section: Introductionmentioning

confidence: 99%

Metabolism of Saikosaponin a in Rats: Diverse Oxidations on the Aglycone Moiety in Liver and Intestine in Addition to Hydrolysis of Glycosidic Bonds

Guoqiang

Tian

et al. 2013

Drug Metabolism and Disposition

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The main objective of the present study was to completely characterize the metabolites of the triterpenoid saikosaponin a (SSa) in rats. To this aim, we compared the metabolites in plasma, bile, urine, and feces samples following oral and i.v. routes of administration using liquid chromatography-diode array detector coupled with hybrid ion trap-time-of-flight mass spectrometry. As a result, besides 2 known metabolites, prosaikogenin f and saikogenin f, 15 new metabolites were detected in all. It was found that SSa is metabolized mainly in phase I manner, i.e., hydration and monooxidation on the aglycone moiety and hydrolysis of the b-glucosidic bond in the liver, and sequential hydrolysis of b-glucosidic and b-fucosidic bonds followed by dehydrogenation, hydroxylation, carboxylation, and combinations of these steps on the aglycone moiety in the intestinal tract. Both the renal and biliary routes were observed for the excretion of SSa and its metabolites. Further, a clear metabolic profile in rats was proposed in detail according to the results from the in vivo animal experiment after different routes of administration. Our results update the preclinical metabolism and disposition data on SSa, which is not only helpful for the future human metabolic study of this compound but also provides basic information for better understanding of the efficacy and safety of prescriptions containing saikosaponins.

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Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice

Cited by 22 publications

References 17 publications

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Targeting Effect of Traditional Chinese Medicine

Metabolism of Saikosaponin a in Rats: Diverse Oxidations on the Aglycone Moiety in Liver and Intestine in Addition to Hydrolysis of Glycosidic Bonds

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