Effects of buprenorphine on nociception and spontaneous locomotor activity in horses

Carregaro, Adriano Bonfim; Luna, Stélio Pacca Loureiro; Mataqueiro, M. I.; Queiroz-Neto, A.

doi:10.2460/ajvr.68.3.246

Cited by 74 publications

(102 citation statements)

References 22 publications

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“…It is highly potent, requiring small volumes of administration and a somatic analgesia duration of six hours (assessed experimentally using thermal threshold testing) is reported at this dose (Carregaro and others 2007). Buprenorphine also shows very good absorption by the oral-transmucosal route, facilitating administration to needle-shy horses.…”

Section: Opioidsmentioning

confidence: 99%

“…I have used it with apparent good effect by this route. Data sheet recommendations state buprenorphine should only be administered after an intravenous sedative agent and cardiovascular stimulation and locomotor excitement lasting for over 12 hours have been reported following the recommended dosing regimen (Carregaro and others 2006, 2007) and I have seen horses compulsively box- walking following use in clinical cases.…”

Section: Opioidsmentioning

confidence: 99%

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Managing orthopaedic pain in horses

Bardell¹

2017

In Practice

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Section: Opioidsmentioning

confidence: 99%

Section: Opioidsmentioning

confidence: 99%

Managing orthopaedic pain in horses

Bardell¹

2017

In Practice

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“…77 When applied as a sole analgesic agent in horses, measurable antinociception has been reported to occur at doses of 10 µg/kg or higher but significant excitement and hemodynamic stimulation were noted as well. 89 Walker 90 reported recently about experience with a 5--day administration of buprenorphine in a filly with severe head and neck trauma choosing the sublingual/buccal mucosal route. The drug provided clinically effective analgesia, when given twice daily, without provoking signs of excitement.…”

Section: Nsaidsmentioning

confidence: 99%

Neuropathic Pain Management in Chronic Laminitis

Driessen

Bauquier

Zarucco

2010

Veterinary Clinics of North America: Equine Practice

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“…Ihr Einsatz beim Pferd kann allerdings mit unerwünschten Nebenwirkungen wie erhöhte lokomotorische Aktivität, Drangwandern und Kopfnicken verbunden sein (Mama et al 1993, Carregaro et al 2007. Da diese Effekte vor allem bei Eingriffen am Pferdekopf ungünstig sind, wird häufig auf analgetischen Alternativen, wie beispielsweise a2-Agonisten, NSAIDs oder Lokalä-nasthetika zurückgegriffen.…”

Section: Introductionunclassified

The effect of romifidine, ketamine and lidocaine on the thermal nociceptive threshold in horses

Wittenberg-Voges¹,

Iburg²,

Hopster³

et al. 2016

PHK

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Zusammenfassung: Ziel der Studie war es, ein besseres Verständnis der analgetischen Effektivität und Wirkungsdauer von Romifidin, Ketamin, Lidocain und ihren Kombinationen zu erhalten. Die Studie wurde verblindet im cross-over Design an 6 adulten Warmblutpferden durchgeführt. Zur Bestimmung des thermischen nozizeptiven Schwellenwertes wurde ein ansteigender thermischer Stimulus mit einer Heizrate von 0,8°C pro Sekunde bis zu einer Zwangsabschalttemperatur von 54°C (Wireless Thermal Testing System, Topcat Metrology Ltd.) seitlich der Nüster am Kopf des Pferdes aufgebracht. Im Abstand von 14 Tagen erfolgte eine Messung nach Kochsalzlösung-Applikation (Kontrolle), Romifidin (Rom 0,05 mg/kg), Ketamin (Ket 0,6 mg/kg), Romifidin in Kombination mit Ketamin (RomKet 0,05 mg/kg, 0,6 mg/kg), Lidocain (Lido 1,3 mg/kg) und Romifidin in Kombination mit Lidocain (RomLido 0,05 mg/kg, 1,3mg/kg). Vor und nach der Arzneimittelgabe (10, 30, 50, 70, 90, 120, 180, 240, 300 und 1350 Minuten) Schlüsselwörter: Sedierung, thermisch-nozizeptiver Schwellenwert, Analgesie, Ketamin, LidocainThe effect of romifidine, ketamine and lidocaine on the thermal nociceptive threshold in horses During painful procedures at the head effective analgesia is necessary in horses. Therefor it was the aim of our study to evaluate the thermal antinociceptive effects of romifidine, ketamine, lidocaine and of the combination of romifidine with ketamine or lidocaine. The study was carried out in 6 healthy horses, between 7 and 20 years old and owned by the University of Veterinary Medicine in Hannover. The study was performed in a blinded randomized cross-over design. Each horse received an intravenous infusion of a placebo (0.9 % saline), romifidine (Rom 0.05 mg/kg), ketamine (Ket 0.6 mg/kg), romifidine with ketamine (RomKet 0.05 mg/kg, 0.6 mg/kg), lidocaine (Lido 1.3 mg/kg) and romifidine with lidocaine (RomLido 0.05 mg/kg, 1.3 mg/kg) with a wash-out period of 14 days between the trials. The thermal stimulus consisted of ramped contact heat (WTT2, Topcat Metrology Ltd) with a heating rate of 0.8°C per second until a safety cut out of 54°C was reached. The stimulation was performed on the head near the nostrils of the horses. Three baseline measurements were taken prior to injection of placebo, romifidine, ketamine, romifidine with ketamine, lidocaine or romifidine with lidocaine. The thermal nociceptive threshold was determined 10, 30, 50, 70, 90, 120, 180, 240, 300 and 1350 minutes after medication. At the same time points degree of sedation and heart rate were assessed and recorded. For statistical analysis the SAS version 9.3 (SAS Institute, Cary, NC) was used. A statistical significance was attributed when p<0.05. Comparisons between treatments at each time point were performed via analysis of variance and post hoc tukey test. Analyses of variance for repeated measurements with post hoc dunnetts t-test were used to compare the values of each time point to the baseline values within the groups. The thermal nociceptive threshold increased in group Rom from...

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Effects of buprenorphine on nociception and spontaneous locomotor activity in horses

Abstract: IV injection of buprenorphine caused a dose-dependent increase in SLA, but only the dose of 10 microg/kg induced analgesia on the basis of results for the experimental method used.

Cited by 74 publications

References 22 publications

Managing orthopaedic pain in horses

Managing orthopaedic pain in horses

Neuropathic Pain Management in Chronic Laminitis

The effect of romifidine, ketamine and lidocaine on the thermal nociceptive threshold in horses

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