Effects of caffeic acid on doxorubicin induced cardiotoxicity in rats

Abstract

Doxorubicin (Dox) is one of the most potent broad-spectrum antitumor anthracycline antibiotics, its use is limited by the development of life-threatening cardiomyopathy.Doxorubicin generates free radicals and induces oxidative stress associated with cellular injury. Further, it has been shown that free radicals are involved in doxorubicin-induced toxicity. The goal of this study is to investigated the cardio-protective effects of caffeic acid on doxorubicin induced cardiotoxicity. The rats were randomized into three equal groups, sham group without treatment, doxorubicin treated group at a dose 3mg/kg IP every other two days and group treated with doxorubicin plus caffeic acid 40mg/day. Two weeks later LV function measurment were performed and blood samples were collected from the heart to measurment plasma levels of cardiac troponin-I (cTn-I), oxidative stress parameter malondialdehyde (MDA) and high a sensitive c-reactive protein (hs-CRP). The hearts were excised for cardiac tissue cytokines (TNF-α, IL-1β, IL-10) measurement and microscopic examination. Rats in the Dox+caffeic acid group had improved LV function, reduced cytokine expression, decreased myocardial marker injury (cTn-I) and less MDA, hs-CRP levels in comparison with the Dox group. Pathological finding appeared nearly normal in the Dox+caffeic acid without fibrosis. The results of the present study reveal that caffeic acid has a promising cardioprotective effect against doxorubicin-induced cardiotoxicity.

Effect of co-administered lopinavir/ritonavir and sulfamethoxazole/trimethoprim on cardiac function and architecture of albino rats

“…23,24 Increase in cardiac MDA level observed in animals treated with LPV/r is consistent with some reported observations. 25 Elevation in cardiac MDA level observed with respect to treatment with these single agents could be attributed to cardiac injury induced by oxidative stress.…”

Exploring the Relationship between COVID-19 Induced Economic Downturn and Women’s Nutritional Health Disparities

“…The correlation between inflammatory markers like C-reactive protein and preeclampsia [10], and the effect of dietary components like caffeic acid on doxorubicin-induced cardiotoxicity [12], further our understanding of disease prevention and management. Additionally, the psychoimmunological assessment of patients recovered from COVID-19 [13] provides valuable information on the pandemic's long-term effects on mental and physical health.…”

Decoding Microbial Enigmas: Unleashing the Power of Artificial Intelligence in Analyzing Antibiotic-Resistant Pathogens and their Impact on Human Health

“…With restricted access to robust surveillance systems and comprehensive data on antibiotic resistance, infectious diseases such as COVID-19, and even cancers, comprehending the scope of these issues and developing suitable strategies to address them becomes increasingly crucial in the eld of scienti c research. Incorporating a focus on bacteria, coronaviruses, and cancer, it is imperative to enhance data collection and surveillance mechanisms to effectively monitor and combat these health challenges (7)(8)(9)(10)(11)(12). A multidisciplinary approach encompassing epidemiology, molecular biology, and medical research is essential to gain insights into the spread and mechanisms of antibiotic resistance, the dynamics of COVID-19 transmission, and the complexities of cancer development and progression (13)(14)(15)(16)(17).Arti cial intelligence (AI) has emerged as a powerful tool in the study of antibioticresistant pathogens and their implications for human health.…”