Effects of combined exercise training in older adults: a potential relationship between muscle fibre satellite cell function and capillarization

Telles, Guilherme Defante; Lixandrão, Manoel Emílio; Conceição, Miguel Soares

doi:10.1113/jp277747

Cited by 1 publication

(1 citation statement)

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“…Most satellite cells in mouse and human muscle are within 5 μm of a capillary, and active satellite cells are located closer than quiescent satellite cells 179 . Capillaries and satellite cells can reciprocally activate each other via diffusion of secreted growth factors (IGF, HGF, VEGF), such that a denser capillary network is associated with a larger SC activation and expansion 106 , and a more pronounced hypertrophic response to resistance exercise 180 . Thus, targeting the endothelium may be an alternative approach for enhancing satellite cells activation and muscle regeneration following ballistic trauma, and this should be considered a major organ to target early in the recovery process.…”

Section: Novel Strategies To Promote Muscle Regeneration After Ballismentioning

confidence: 99%

Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

et al. 2021

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One major cause of traumatic injury is firearm-related wounds (i.e., ballistic trauma), common in both civilian and military populations, which is increasing in prevalence and has serious long-term health and socioeconomic consequences worldwide. Common primary injuries of ballistic trauma include soft-tissue damage and loss, haemorrhage, bone fracture, and pain. The majority of injuries are of musculoskeletal origin and located in the extremities, such that skeletal muscle offers a major therapeutic target to aid recovery and return to normal daily activities. However, the underlying pathophysiology of skeletal muscle ballistic trauma remains poorly understood, with limited evidence-based treatment options. As such, this review will address the topic of firearm-related skeletal muscle injury and regeneration. We first introduce trauma ballistics and the immediate injury of skeletal muscle, followed by detailed coverage of the underlying biological mechanisms involved in regulating skeletal muscle dysfunction following injury, with a specific focus on the processes of muscle regeneration, muscle wasting and vascular impairments. Finally, we evaluate novel approaches for minimising muscle damage and enhancing muscle regeneration after ballistic trauma, which may have important relevance for primary care in victims of violence.

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Section: Novel Strategies To Promote Muscle Regeneration After Ballismentioning

confidence: 99%

Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

et al. 2021

View full text Add to dashboard Cite

show abstract

Effects of combined exercise training in older adults: a potential relationship between muscle fibre satellite cell function and capillarization

Cited by 1 publication

References 5 publications

Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

Firearms-related skeletal muscle trauma: pathophysiology and novel approaches for regeneration

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