Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial

Ito, Naoki; Seki, Sumihiko; Ueda, Fumitaka

doi:10.3390/md16120482

Cited by 43 publications

(61 citation statements)

References 55 publications

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“…Similar results on the improvement of the skin were obtained by Ito et al [109] in 40 healthy women by the ingestion of 30-mL of fish-derived collagen and ornithine (CPO) drink. After eight weeks of supplementation, skin elasticity increased in CPO treatments.…”

Section: Improvement Of Skin Propertiessupporting

confidence: 80%

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

Aguirre-Cruz¹,

León-López

Cruz-Gómez³

et al. 2020

Antioxidants

131

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Antioxidants are molecules that delay or inhibit the oxidation of other molecules. Its use significantly increased in recent years in the diet of people. Natural antioxidants are replacing the use of synthetic antioxidant ingredients due to their safety, nutritional, and therapeutic values. Hydrolyzed collagen (HC) is a popular ingredient considered to be an antioxidant. This low molecular weight protein has been widely utilized due to its excellent biocompatibility, easy biodegradability, and weak antigenicity. It is a safe cosmetic biomaterial with good moisturizing properties on the skin. The antioxidant properties of HC are conditioned to the size of the molecule: the lower the molecular weight of peptides, the greater the ability to donate an electron or hydrogen to stabilize radicals. The antioxidant capacity of HC is mostly due to the presence of hydrophobic amino acids in the peptide. The exact mechanism of peptides acting as antioxidants is not clearly known but some aromatic amino acids and histidine are reported to play an important role in the antioxidant activity. Oral ingestion of HC increases the levels of collagen-derived peptides in the blood torrent and improves the skin properties such as elasticity, skin moisture, and transepidermal water loss. Additionally, daily intakes of HC protect the skin against UV melasma, enhances the fibroblast production and extracellular matrix of the skin. HC has been identified as a safe cosmetic ingredient for topical formulations with good moisturizing properties at the stratum corneum layer of the skin. It reduces the effects of skin aging (dryness, laxity, and wrinkles). The use of HC as a principal ingredient in safe formulations for skin protection was reviewed and compared when it is used by topical and/or oral administration.

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Section: Improvement Of Skin Propertiessupporting

confidence: 80%

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

Aguirre-Cruz¹,

León-López

Cruz-Gómez³

et al. 2020

Antioxidants

131

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“…Marine‐based collagen scaffold has applications in bone (TE), [ 74–76 ] wound healing, [ 77 ] food, and nutraceuticals and nutricosmetic. [ 78–82 ]…”

Section: Source Of Collagenmentioning

confidence: 99%

Bioprinting of Collagen: Considerations, Potentials, and Applications

Lee

Suen

Ng³

et al. 2020

Macromolecular Bioscience

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Collagen is the most abundant extracellular matrix protein that is widely used in tissue engineering (TE). There is little research done on printing pure collagen. To understand the bottlenecks in printing pure collagen, it is imperative to understand collagen from a bottom‐up approach. Here it is aimed to provide a comprehensive overview of collagen printing, where collagen assembly in vivo and the various sources of collagen available for TE application are first understood. Next, the current printing technologies and strategy for printing collagen‐based materials are highlighted. Considerations and key challenges faced in collagen printing are identified. Finally, the key research areas that would enhance the functionality of printed collagen are presented.

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“…[11][12][13][14][15] In addition to the extraction from land animals, to date, marine-derived collagen has also been highlighted in different fields considering redevelopment of 75% of fish waste materials (eg, bone and scale) and the benefits of unique collagen peptides (eg, Ala-Hyp-Gly and Ser-Hyp-Gly). [16][17][18][19] The efficacy of oral hydrolyzed fish collagen for retarding skin aging has been unveiled by several clinical studies as indicated by improvement of skin parameters, such as hydration, wrinkles, pores, or collagen content in human skin. [20][21][22][23][24][25][26][27][28] Furthermore, Djulis has recently been identified as a potential ingredient for skin improvement.…”

mentioning

confidence: 99%

Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow’s feet, and collagen content: A double‐blind, randomized, placebo‐controlled trial

Lin

Alexander²,

Liang

et al. 2020

J of Cosmetic Dermatology

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Background: The efficacy of Djulis for skin care is currently based on cellular or animal models, and the clinical aspect is not in place. Aim: This clinical study is to investigate the synergistic effect of fish collagen and Djulis (Chenopodium formosanum Koidz.) for improvement of skin parameters. We used the combination of hydrolyzed collagen and Djulis to develop a new functional formula for skin improvement. Patients/Methods: Fifty volunteers were randomly allocated (in a 1:1 ratio) to the placebo or collagen drink group. Volunteers were required to consume a 50 mL of a collagen drink or placebo drink daily for 8 weeks. For measurements, the indexes of skin conditions were measured at the baseline and 4 and 8 weeks. Results: The improvements of skin hydration, brightness, crow's feet, texture, wrinkles, pores, spots, and collagen content after 8 weeks in collagen group were 17.8%, 5.4%, 14.9%, 9.9%, 29.3%, 10.4%, 9.9%, and 22.3%, respectively. Noticeably, over 68% of subjects got improved for their skin parameters after 8-week intake of collagen drink. The improvement levels indicated competitive skin improvement effects in comparison with previous studies. Conclusion: This clinical study demonstrates the synergistic effect of fish collagen and Djulis (the main components) for the substantial improvements in hydration, brightness, crow's feet, texture, wrinkles, pores, surface spots, and collagen content in skin. The collagen drink comprehensively improved skin parameters for most subjects after 4-week intake and manifested competitive efficiency in comparison with other similar studies. We convince that the collagen drink may delay skin aging process and improve skin aging parameters.

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Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 43 publications

References 55 publications

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

Bioprinting of Collagen: Considerations, Potentials, and Applications

Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow’s feet, and collagen content: A double‐blind, randomized, placebo‐controlled trial

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