Effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after percutaneous coronary intervention in patients with coronary heart disease

Abstract

Background: Percutaneous coronary intervention (PCI) is an important means for the treatment of coronary atherosclerotic heart disease and has effectively reduced the mortality of coronary heart disease. However, reperfusion can also cause certain damage to the vascular endothelium, leading to the major adverse cardiovascular events. Compound Danshen dropping pill is a Chinese patent medicine preparation. At present, many studies have evaluated the effect of compound Danshen dropping pill in reducing the incidence of adverse cardiovascular events after PCI. This study systematically evaluated the effect of compound Danshen dropping pills on major adverse cardiovascular events and quality of life after PCI and provides a reference for clinical application and research.Methods: All randomized controlled trials on the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease were searched for. The search was conducted from database inception to January 2022. Data extraction and quality assessment were performed by 2 reviewers according to the Protocol Guidelines for Systematic Reviews and Meta-analyses Protocols statement guidelines. Meta-analysis was performed using Review Manager Version 5.4 software and Stata 16 software. Results:The results of this study will allow for systematically evaluation of the effects of compound Danshen dropping pills on adverse cardiovascular events and quality of life after PCI for coronary heart disease.Conclusion: This study will provide objective evidence of a basis for compound Danshen dropping pills reducing adverse cardiovascular events and improving quality of life after PCI.

Preventive effect and mechanism of compound Danshen dripping pills on contrast-induced nephropathy after percutaneous coronary interventional

“…CDDP can inhibit platelet aggregation, reduce inflammation and damage of vascular endothelium. At present, a number of studies have evaluated the reduction of CDDP in the incidence of cardiovascular adverse events after PCI ( 42 ). Rong Y et al observed that CDDP preconditioning could decrease the incidence of CIN in patients with PCI.…”

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

“…Acute coronary artery occlusion is often associated with atherosclerosis and plaque rupture, leading to myocardial ischemia or even infarction ( Mehta et al, 2022 ). An enormous number of laboratory and clinic studies have shown that a series of formulas based on the DSF can improve cardiac function and morphology after acute myocardial infarction, indicating a promising myocardial protective effect of DSF ( Lv et al, 2022 ; Sun and Zhang, 2022 ; Xu et al, 2022 ). Several studies have demonstrated that DS (either as a prodrug or as the formulation) has a beneficial effect on the heart during the pathological process of atherosclerosis both at progression stage and acute exacerbation stage ( Liu et al, 2022c ).…”

“…There are numerous records about the use of natural plants, animals, and minerals to treat diseases in the classics of traditional Chinese medicine, and these materials are collectively referred to as Traditional Chinese Medicine (TCM) ( Ai et al, 2023 ). Traditional Chinese Medicine has constructed the foundations of a sophisticated traditional medical system through thousands of years of medication discovery, experience accumulation as well as knowledge preservation, and served as a safeguard for the health of the Chinese since ancient times ( Lv, R. et al, 2022 ; Zhang et al, 2023 ). In the past few decades, as a result of the increased attention given to TCM around the world, it has become an increasingly essential healthcare system not just in China but also globally, which may stably provide innovative therapies for patients with life-threatening diseases in the modern society ( Xing and Liu, 2021 ).…”

Application of Deep Learning Technique for the Detection of Coronary Heart Disease (CHD)

“…They may increase the precision of classification approaches and aid in the execution of both classification and prediction models, which are carried out using the Python programming language. The heart prediction system may be used by medical professionals to enhance service quality by using data mining expertise to give a method for identifying hidden patterns in the data [18]- [20].…”