Effects of crosslinked dextran in hydroxylpropyl methylcellulose on soft tissue augmentation in rats

Cena, Rohani; Park, June; Son, Kyu Yeol; Kim, Deok Song; Kang, Mun Il; Park, Sang Ik; Moon, Du Geon; Yang, Dae Yul; Yu, Dong; Lee, Jae Il; Cho, Kyoung Oh

doi:10.1002/jbm.b.32989

Cited by 5 publications

(8 citation statements)

References 41 publications

(88 reference statements)

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“…An effective dermal filler must, most importantly, satisfy safety needs, including excellent biocompatibility, nonimmunogenicity (or a weak immune response), biodegradability without a toxic secretome, and minimal risk of infection [4,11]. It should also be long-lasting, with easy installation, and inexpensive [7]. Although it is difficult to attain all of these desired characteristics, recently commercialized fillers are coming close to meeting these goals.…”

Section: Introductionmentioning

confidence: 99%

A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction

Kim¹,

Lee²,

Kim³

et al. 2015

Journal of Microbiology and Biotechnology

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In this study, we developed a composite filler comprising cross-linked hyaluronic acid (HA) and human collagen (COL) derived from the human umbilical cord with the aim of improving its biocompatibility and longevity compared with commercially available fillers. After HA/ COL composite fillers were made in two different ratios (10:1 and 5:1), the physical properties of the fillers were evaluated. The interior morphologies and in vivo weight change of these hydrogels were also characterized at 1-16 weeks after injection into mice. To evaluate their biocompatibility and durability in vivo, we injected the composite fillers into nude mice subcutaneously. The variations of injected gel weight were measured and compared with the commercial dermal fillers (Restylane and TheraFill). The composites showed improved or similar physical properties (complex viscosity of 19-22 × 10(5) cP, and injection force of 10- 12 N) over the commercial dermal fillers. Sixteen weeks following the injection, the ratio of remaining composite filler weight to initial weight (75.5 ± 16.9%; 10:1) was shown to be greater than that of the commercial fillers (43.2 ± 8.1%, Restylane; 12.3 ± 5.3%, TheraFill). In addition, immunohistochemical analysis with angiogenesis-related markers such as isolectin and vWF revealed newly formed blood vessels and cellular influx into the composite filler, which were not observed in the other fillers. These results clearly suggest that the HA/COL composite filler is a superior candidate for soft tissue reconstruction. The filler we developed may be a suitable candidate as an injectable dermal filler for tissue augmentation in humans.

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Section: Introductionmentioning

confidence: 99%

A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction

Kim¹,

Lee²,

Kim³

et al. 2015

Journal of Microbiology and Biotechnology

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“…Previously, the effects of the same CD gel product used in our study were assessed in a 24-month rat study. 14 The augmentation effects of CD gel decreased slowly but were largely maintained. In addition, the sequential volume changes from 3 weeks to 24 months after injection were not significant.…”

Section: Discussionmentioning

confidence: 99%

“… 3 10 In animal models, CD-based materials showed good efficacy and biocompatibility for soft-tissue augmentation. 8 11 12 13 14 Recently, it has been used as a bulking substance for the treatment of vesicoureteral reflux and urinary incontinence. 15 16 17 Based on these characteristics, CD may be an appropriate substance for GPA.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique

Yang

Lee

et al. 2018

Asian J Androl

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There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study. This prospective, single-arm, multicenter study enrolled twenty healthy adult men who underwent glans penis augmentation between June and August 2013. Cross-linked dextran gel was injected into the glans penis using a simple and easy technique. The sizes of the glans penis and individual satisfaction were assessed. Any adverse event was also reported. A total of 18 individuals were analyzed; two of them were lost to follow-up. The mean procedure time and injected volume were about 30 min and 6.6 ± 0.9 ml, respectively. The mean surface areas of the glans at baseline and 24 weeks were 20.0 ± 3.5 cm2 and 33.6 ± 5.4 cm2, respectively, representing a mean increase of 68.7% ± 14.0% (P < 0.001). Sixteen individuals (88.9%) were satisfied with the outcomes, and none were dissatisfied. There were no serious adverse events during the study. Cross-linked dextran gel injection for glans penis augmentation was easy and showed a significant augmentative effect on the glans penis, good durability, and was well tolerated without serious adverse events. Therefore, cross-linked dextran gel injection may be an effective, new technique for glans penis augmentation.

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“…However, enzymes such as hyaluronidase and free radicals can rapidly degrade HA polymers [ 20 , 21 ]. In an effort to achieve a longer-lasting effect, DiHM and PDiHM were introduced and recently attracted attention as novel materials for soft tissue augmentation [ 22 , 23 , 24 , 25 , 26 , 27 ]. Dextran microspheres (diameter: 80–120 μm) are composed of cross-linked dextran molecules [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hyaluronic acid fillers are currently used for their good biocompatibility, however their short durability is a problem [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. To achieve longer-lasting effect of fillers, cross-linked dextran-based and PMMA mixed novel materials have recently been developed [ 22 , 23 ]. Cross-linked dextran can stimulate fibroblasts to produce collagen fibers in connective tissue [ 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats

Huh

Kim

et al. 2015

IJMS

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This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (n = 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (p < 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, p < 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields.

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Effects of crosslinked dextran in hydroxylpropyl methylcellulose on soft tissue augmentation in rats

Cited by 5 publications

References 41 publications

A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction

A Composite Dermal Filler Comprising Cross-Linked Hyaluronic Acid and Human Collagen for Tissue Reconstruction

Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique

Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats

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