2016
DOI: 10.1177/0394632016638099
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Effects of curcumin on synapses in APPswe/PS1dE9 mice

Abstract: Significant losses of synapses have been demonstrated in studies of Alzheimer's disease (AD), but structural and functional changes in synapses that depend on alterations of the postsynaptic density (PSD) area occur prior to synaptic loss and play a crucial role in the pathology of AD. Evidence suggests that curcumin can ameliorate the learning and memory deficits of AD. To investigate the effects of curcumin on synapses, APPswe/PS1dE9 double transgenic mice (an AD model) were used, and the ultra-structures of… Show more

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Cited by 32 publications
(20 citation statements)
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“…We found that after LC treatment, 42% of synaptophysin and 59% of PSD95 protein levels were restored in the cerebellum of GFAP-IL6 mice. In correspondence with our results, others have also found that using curcumin on the APPswe/PS1dE9 double transgenic mouse model restores the quantity and structure of the synapses measured by western blots for the PSD95 hippocampal CA1 area, with the curcumin treatment increasing the expression of this protein 47 .…”
Section: Discussionsupporting
confidence: 92%
“…We found that after LC treatment, 42% of synaptophysin and 59% of PSD95 protein levels were restored in the cerebellum of GFAP-IL6 mice. In correspondence with our results, others have also found that using curcumin on the APPswe/PS1dE9 double transgenic mouse model restores the quantity and structure of the synapses measured by western blots for the PSD95 hippocampal CA1 area, with the curcumin treatment increasing the expression of this protein 47 .…”
Section: Discussionsupporting
confidence: 92%
“…He and colleagues (2016) [99] investigated the effects of curcumin on synapses of APPswe/PS1dE9 double transgenic mice, and the ultra-structures of synapses and synapse-associated proteins. Six months after administration, few abnormal synapses were observed upon electron microscopy in the hippocampal CA1 areas of the APPswe/PS1dE9 double transgenic mice.…”
Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning
confidence: 99%
“…Immunohistochemistry and western blot analyses revealed that the expressions of PSD95 and Shank1 were reduced in the hippocampal CA1 areas of the APPswe/PS1dE9 double transgenic mice, but curcumin treatment increased the expressions of these proteins. Our findings suggest that curcumin improved the structure and function of the synapses by regulating the synapse-related proteins PSD95 and Shank1 [99]. …”
Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning
confidence: 99%
“…As a well-studied member of the MAGUK family, PSD-95 is the major scaffold protein of dendritic spines, which is involved in ageing, AD and numerous psychiatric disorders (Savioz et al 2014). Several reports have demonstrated that hippocampal PSD-95 levels are significantly decreased in 9-month-old APP/PS1 mice (Inestrosa et al 2013;He et al 2016;Liu et al 2017). Another study showed that PSD-95 expression was significantly increased in the frontal cortex of aged cognitively impaired rats and unaltered in the hippocampus (Preissmann et al 2012).…”
Section: Discussionmentioning
confidence: 99%