Effects of dietary fish oil on tissue glutathione and antioxidant defense enzymes in mice with murine aids

Xi, S.; Lh, Chen

doi:10.1016/s0271-5317(00)00214-1

Cited by 19 publications

(7 citation statements)

References 41 publications

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“…However, a recent study by Turkez et al (2012) has shown that EPA provided cytoprotection against TCDD-induced stress by enhancing the total antioxidant capacity in rat hepatocytes. The protective effect of fish oil rich in n-3 fatty acids against various nephrotoxic conditions (Goksu Erol et al 2013;Priyamvada et al 2008;Naqshbandi et al 2012;Thakkar et al 2000;Xi and Chen 2000) and results from the present study strongly support the ability of EPA as a potent nephroprotectant.…”

Section: Discussionsupporting

confidence: 76%

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Palaniswamy

Vishwanadha

Singaravelu

2014

Cell Stress and Chaperones

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Humans are systemically exposed to persistent organic pollutants, of which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has become a major environmental concern. Exposure to TCDD results in a wide variety of adverse health effects which is mediated by oxidative stress through CYP1A1 activation and arachidonic acid metabolites. Eicosapentaenoic acid (EPA) exhibits antioxidant property and competes with arachidonic acid in membrane phospholipids and produces anti-inflammatory EPA derivatives. Since both EPA and its derivatives have been reported to enhance the antioxidant mechanism, the present study aimed at studying whether EPA could offer protection against TCDDinduced oxidative stress and nephrotoxicity in Wistar rats. Estimation of kidney markers (serum urea and creatinine) and histopathological studies revealed that EPA treatment significantly reduced TCDD-induced renal damage. TCDDinduced oxidative damage was reflected in a significant increase in CYP1A1 activity and lipid peroxide levels with a concomitant decline in non-enzymic antioxidant (GSH) and various enzymic antioxidants such catalase (CAT), superoxide dismutase (SOD), glutathione-S-transferase (GST), and glutathione peroxidase (GPx). In addition, TCDD-induced oxidative stress also resulted in decline in Na + -K + and Mg 2+ATPases activities with increase in Ca 2+ ATPases activity. Oral treatment with EPA showed a significant cytoprotection against TCDD-induced renal oxidative stress by decreased CYP1A1 activity and enhanced antioxidant status. TCDD-induced alterations in ATPase enzyme activities were also prevented by EPA treatment. Our results show clear evidence that EPA ameliorates TCDD-induced oxidative stress and kidney damage; thus suggest the potential of EPA as an effective therapeutic agent against toxic effects mediated through redox imbalance.

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Section: Discussionsupporting

confidence: 76%

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Palaniswamy

Vishwanadha

Singaravelu

2014

Cell Stress and Chaperones

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“…Cells stimulated with LPS have a 6-to 10-fold increase in releasing reactive oxygen species (ROS), including superoxide and hydrogen peroxide [46,47]. Previous findings in our laboratory demonstrated that supplementing fish oil to mice partially restored the tissue antioxidant defense systems that were suppressed by infection with murine leukemia virus [48]. Therefore, it is also possible that EPA may affect AP-1 and NF-nB activities via reducing ROS production induced by LPS.…”

Section: Discussionmentioning

confidence: 98%

Eicosapentaenoic acid prevents lipopolysaccharide-stimulated DNA binding of activator protein-1 and c-Jun N-terminal kinase activity

Zhao

Chen

2005

The Journal of Nutritional Biochemistry

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“…The Se enzymes of the glutathione peroxidase and thioredoxin reductase family function as antioxidants [7]. GSH has antioxidative properties and is a major factor in the defense against oxidative stress [30]. Hill and Burk reported that Se deficiency in rats caused an increase of GSH in the liver [31].…”

Section: Influence Of the Selenium Deficiency On Oxidative Stress Parmentioning

confidence: 99%

Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets

Schäfer

Kyriakopoulos

Gessner

et al. 2004

Journal of Trace Elements in Medicine and Biology

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Effects of dietary fish oil on tissue glutathione and antioxidant defense enzymes in mice with murine aids

Cited by 19 publications

References 41 publications

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats

Eicosapentaenoic acid prevents lipopolysaccharide-stimulated DNA binding of activator protein-1 and c-Jun N-terminal kinase activity

Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets

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