Effects of dietary supplementation of guanidinoacetic acid on physiological response of broiler chicken exposed to repeated lactic acid injection

Boroumandnia, Zeinab; Khosravinia, Heshmatollah; Masouri, Babak; Kavan, Bahman Parizadian

doi:10.1080/1828051x.2021.1873075

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Boroumandnia et al (2021), reported that GAA supplementation of up to 3% resulted in calcium levels of 7.79-8.58 mg/dL. In this study, GAA supplementation with different protein levels resulted in blood serum calcium levels ranging from 9.70-13.63 mg/dL, which were higher than Boroumandnia et al (2021). This study showed that high-protein feed treatment led to higher blood calcium levels.…”

Section: Serum Biochemistry Of Broiler Chickenmentioning

confidence: 61%

“…Serum calcium levels were higher in the low protein diet than in the standard protein. Boroumandnia et al (2021), reported that GAA supplementation of up to 3% resulted in calcium levels of 7.79-8.58 mg/dL. In this study, GAA supplementation with different protein levels resulted in blood serum calcium levels ranging from 9.70-13.63 mg/dL, which were higher than Boroumandnia et al (2021).…”

Section: Serum Biochemistry Of Broiler Chickenmentioning

confidence: 62%

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Supplementation of guanidinoacetic acid in feed with different levels of protein on intestinal histomorphology, serum biochemistry, and meat quality of broiler

Rahmawati

Hanim

2022

J. Indonesian Trop. Anim. Agric.

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This study aimed to investigate the effect of guanidinoacetic acid (GAA) with different protein levels in feed on intestinal histomorphology, serum biochemistry, and meat quality of broiler chicken. GAA is the only direct precursor of creatine and is involved in the synthesis of bioenergy cellular. This research used 1.176 day-old chicks of the Lohmann Indian River strain that were reared for 35 days. The supplementation effect was investigated using six treatments, i.e., two levels of feed protein and three levels of GAA, with seven replications. Broiler chickens were fed with 23% and 21% crude pro-tein during the pre-starter phase, 21% and 19% during the starter phase, and 19% and 17% during the finisher phase, with a GAA addition of 0 g/ton, 600 g/ton, and 1200 g/ton, respectively. The result showed GAA supplementation with different protein levels reduced triglyceride (P<0,05), cholesterol levels in serum (P<0,05), increased surface area of the microvilli (P<0,05), pH of breast meat (P<0,05), but did not affect the chemical quality of breast meat (P>0,05). In conclusion, GAA supplementation in different level protein diets increased the surface area of the microvilli, pH of breast meat, reduce se-rum cholesterol and triglycerides, without affecting the chemical quality of broiler meat.

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Section: Serum Biochemistry Of Broiler Chickenmentioning

confidence: 61%

Section: Serum Biochemistry Of Broiler Chickenmentioning

confidence: 62%

Supplementation of guanidinoacetic acid in feed with different levels of protein on intestinal histomorphology, serum biochemistry, and meat quality of broiler

Rahmawati

Hanim

2022

J. Indonesian Trop. Anim. Agric.

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“…Increased blood lactic acid concentrations are likely to play a role in broiler chicken SDS. Dietary GAA at 2.4 and 3.0 g/kg reduced mortality in broiler chickens with acute lactic acidosis but had an adverse effect on growth performance (Boroumandnia et al, 2021). However, there was no clear evidence that extra nutritional GAA significantly influenced the incidence of SDS in chickens.…”

Section: Effects Of Dietary Gaa During Stress Conditionsheat Stress C...mentioning

confidence: 93%

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

Asiriwardhana

Bertolo²

2022

Front. Anim. Sci.

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Guanidinoacetic acid (GAA) is an amino acid derivative and precursor for creatine which plays a significant role in energy metabolism. However, because of creatine’s instability during the manufacturing process and cost, GAA has been explored as an effective alternative to creatine supplements. GAA has been tested as a potential feed additive to enhance energy utilization and growth performance in the poultry and swine industries. Moreover, GAA has been combined with methionine to improve growth outcomes and may also act as an arginine-sparing agent in birds. The safety of the GAA supplements for animals, consumers, and the environment and its efficacy in numerous livestock species have been proven. This narrative review discusses the scientific evidence regarding the metabolism and effects of GAA supplementation in swine and poultry, identifying the knowledge gaps and future directions for further research on GAA supplementation. A systematic search of the literature identified published research findings related to GAA supplementation in swine and poultry and their findings are summarized in this narrative review to confirm the impacts of GAA supplementation on growth performance, reproductive performance, and meat quality in swine and poultry. Amongst its many demonstrated benefits, GAA is effective at improving body creatine concentration, growth parameters, feed conversion ratio, and performance of animals. Although GAA exerts many non-creatine roles, including the stimulation of insulin secretion, neuromodulation, and vasodilation, further research may require in-depth elaboration.

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Guanidinoacetic acid supplementation and stocking density effects on broiler performance: behavior, biochemistry, immunity, and small intestinal histomorphology

Alaa,

Abdel Razek,

Tony

et al. 2024

Acta Vet Scand

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Background Rearing poultry under stressful high stocking density (HSD) conditions is a common commercial practice to increase profitability, despite its negative effects on broiler physiology and welfare. Many feed additives are used to alleviate the negative impact of such practices. This study investigated the ameliorative effects of guanidinoacetic acid (GAA) on growth performance, ingestive behavior, immune response, antioxidant status, stress indicators, and intestinal histomorphometry of broilers subjected to HSD. A total of 364 male broilers were randomly allocated into four treatments with 7 replicates each in a 2 × 2 factorial arrangement: two stocking densities (SD) (10 and 16 birds/m2) and two GAA levels (0 and 0.6 g/kg feed). Results Body weight, weight gain, feed intake, feed conversion ratio, production efficiency factor, dressing yield, and ingestive behavior were negatively affected by HSD, whereas the mortality rate was unaffected (P > 0.05). GAA improved the overall growth performance and dressing percentage (P < 0.05). In the HSD group, the immune response decreased at d 21 (P < 0.05). Creatine kinase, glutathione peroxidase (GPX), superoxide dismutase, catalase, triglycerides, and villus length and width (ileum) were reduced, whereas corticosterone (CORT) was increased (P < 0.05). Moreover, GAA increased the hemagglutination-inhibition titer at 21 days and the levels of lactate dehydrogenase, GPX, and catalase and decreased the levels of creatinine, alanine aminotransferase, nitrite, triglycerides, and CORT (P < 0.05). SD and GAA did not affect malondialdehyde or other biochemical parameters (P > 0.05). Conclusions Dietary GAA supplementation can improve productivity and antioxidant status and reduce stress in broilers reared in a HSD environment.

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Effects of dietary supplementation of guanidinoacetic acid on physiological response of broiler chicken exposed to repeated lactic acid injection

Cited by 5 publications

References 42 publications

Supplementation of guanidinoacetic acid in feed with different levels of protein on intestinal histomorphology, serum biochemistry, and meat quality of broiler

Supplementation of guanidinoacetic acid in feed with different levels of protein on intestinal histomorphology, serum biochemistry, and meat quality of broiler

Guanidinoacetic acid supplementation: A narrative review of its metabolism and effects in swine and poultry

Guanidinoacetic acid supplementation and stocking density effects on broiler performance: behavior, biochemistry, immunity, and small intestinal histomorphology

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