Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: II. Biological Experiments

Barendsen, G.W.; Beusker, T.L.J.; Vergroesen, A.J.; Budke, L.

doi:10.2307/3570859

Cited by 246 publications

(60 citation statements)

References 7 publications

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“…Several laboratories have recently investigated cell killing effects due to combined low-and high-LET radiations, extending the earlier work by Barendsen et al (1960) and Todd (1973). All reports using fast neutrons and…”

Section: Combined Hi and Low-let Radiationsmentioning

confidence: 80%

“…Several years later, Barendsen and his colleagues were the first to study the killing of cultured human T~1 cells with polonium alpha-particles (Barendsen et al, 1960). Later they used cyclotron-produced helium ions and deuterons at the Hammersmith Hospital in London (Barendsen et al, 1963(Barendsen et al, , 1966Barendsen and Walter, 1964;Barendsen, 1968a).…”

Section: B Relative Biological Effectivenessmentioning

confidence: 99%

“…Barendsen et al (1960) and Todd (1973) concluded earlier that the two types of radiation kill cells by independent actions. This problem is also pertinent to the basic question as to whether or not high-LET particles cause only irreversible lethal lesions in cells.…”

Section: Combined Hi and Low-let Radiationsmentioning

confidence: 99%

See 2 more Smart Citations

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

199

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Section: Combined Hi and Low-let Radiationsmentioning

confidence: 80%

Section: B Relative Biological Effectivenessmentioning

confidence: 99%

See 1 more Smart Citation

Heavy-Ion Radiobiology: Cellular Studies

Blakely

Ngo

Curtis

et al. 1984

Advances in Radiation Biology

199

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“…While IR can cause a plethora of biochemical and structural changes in DNA experimentally, [12][13][14][15][16][17][18][19] the most lethal event is widely considered to be double strand breaks. 20 …”

mentioning

confidence: 99%

Pictures, progress, and perplexities: The immediate cell biological effects of ionizing radiation

Smith

Kao²

2004

Cancer Biology & Therapy

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“…It is well known that ionizing radiations could damage the living samples [4]. In order to avoid the damage, the delivery of high photon flux in an extremely short time is imperative to image the living specimens before the ionization radiations could induce damage.…”

Section: Introductionmentioning

confidence: 99%

Contact Microscopy using a Compact Laser Produced Plasma Soft X-Ray Source

et al. 2016

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Soft X-ray contact microscopy potentially allows imaging of wet living biological specimens at a spatial resolution higher than optical microscopy and without many of the constraints of scanning electron microscopy. In this paper, we present the development of a laboratory scale contact microscope that uses a laser produced plasma soft X-ray source. The source is based on a double-stream gas-puff target approach and it operates in the "water window" spectral range which enables to capture images of biological samples with a natural contrast. In the preliminary experiments the contact microscope system has been used for imaging of fixed and dried non-malignant HCV29 human bladder cell lines cultured on polymethyl methacrylate photoresists. The samples were exposed with 150 pulses of soft X-rays as an initial test to demonstrate the possibility of image formation. The soft X-ray contact images registered in the photoresists exhibit high resolution in the atomic force microscopy topography which indicates the potential application of soft X-ray contact microscopy in life science to examine small features as small as few tens of nm. The technique could also be used for living cell imaging with further optimization of the microscope system and development of a special specimen holder. The details of the soft X-ray contact microscopy technique and the experimental results are presented and discussed.

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Effects of Different Ionizing Radiations on Human Cells in Tissue Culture: II. Biological Experiments

Cited by 246 publications

References 7 publications

Heavy-Ion Radiobiology: Cellular Studies

Heavy-Ion Radiobiology: Cellular Studies

Pictures, progress, and perplexities: The immediate cell biological effects of ionizing radiation

Contact Microscopy using a Compact Laser Produced Plasma Soft X-Ray Source

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