Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction

Vona, Margherita; Codeluppi, G.M.; Iannino, Tiziana; Ferrari, Enrico; Bogousslavsky, Julien; Segesser, Ludwig K. von

doi:10.1161/circulationaha.108.821736

Cited by 128 publications

(89 citation statements)

References 39 publications

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“…This strategy could reduce the well-known low compliance of obese children faced with current structured PA programs. 106 The first step low-intensity PA should be considered the needed phase of being more confident with PA, similar to the recommendation suggested for rehabilitation in postmyocardial infarction adults, 107 or for long-term inactivity because of important trauma or fracture. The first-phase PA should be considered a re-education to move.…”

Section: A Multiple-step Strategymentioning

confidence: 99%

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Brambilla¹,

Pozzobon

Pietrobelli

2010

Int J Obes

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Physical activity (PA) and diet directly influence obesity and metabolic syndrome (MS) as important determinants of body composition. Understanding how PA relates to MS in youth is of great importance, and could offer a common strategy for clinical and public health approaches to control this condition. The underlying disorder of MS is a condition of insulin resistance, and a strong relationship between PA level and insulin sensitivity is clearly ascertained. The type, duration, frequency and intensity of PA affect fuel metabolism, in particular carbohydrate and lipid oxidation. The possible modulation of metabolism because of increased fat oxidation by PA is the basis for both prevention and restoration of insulin resistance and MS in obese children. In daily clinical practice, diet followed by pharmacologic treatment are usually the approaches taken, whereas PA is often considered just a suggestion. Although diet and PA have different effects on body composition, with both contributing to fat loss, only PA increases muscle mass and thus has a direct effect on metabolic function, expressed by changes in cardiovascular risk factors. Therefore, it is important to remember their complementary but different targets in daily clinical practice, such as body weight control for diet and metabolic health for PA. In this review, we have summarized the literature on the relationship between PA and MS in pediatrics. Then, we have analyzed the possibility of using PA for MS treatment, as an alternative to drugs, by discussing the results of intervention studies, reasons for low compliance to PA, related benefits, adherence difficulties and costs. Finally, we have tried to suggest recommendations for a multiple-step PA strategy in children and adolescents at risk for MS, by considering PA as the 'key' player in treatment.

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Section: A Multiple-step Strategymentioning

confidence: 99%

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Brambilla¹,

Pozzobon

Pietrobelli

2010

Int J Obes

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“…6) Furthermore, it has been reported that impaired NO-dependent vasodilation is an independent predictive factor of cardiac events in IHD patients. 6) Although other reports found that a few months of aerobic exercise could improve vascular endothelial dysfunction assessed by the conventional method for flow-mediated vasodilation, 7,8) there is little evidence on the influence of stretching exercises.…”

mentioning

confidence: 99%

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

et al. 2013

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SummaryThe purpose of this study was to clarify the acute effects of a single session of stretching exercises on vascular endothelial function and peripheral circulation in patients with acute myocardial infarction. This study evaluated 32 patients (mean age, 66 ± 9 years) who received phase I cardiac rehabilitation after acute myocardial infarction. Five types of stretching exercises were performed on the floor: wrist dorsiflexion, close-legged trunk flexion, open-legged trunk flexion, open-legged lateral trunk bending, and cross-legged trunk flexion. Each exercise entailed a 30-second stretching followed by a 30-second relaxation, and was repeated twice. Low-and high-frequency components (LF and HF) of heart rate variability (LF, 0.04-0.15 Hz; HF, 0.15-0.40 Hz) were analyzed, and HF and LF/HF were used as indices of parasympathetic and sympathetic nervous activities, respectively. Reactive hyperemia peripheral arterial tonometry (RH-PAT) index was measured and used as a parameter for vascular endothelial function. Transcutaneous oxygen pressure (tcPO 2 ) on the right foot and chest was also measured, and the Foot-tcPO 2 /Chest-tcPO 2 ratio was used as a parameter for peripheral circulation. The HF, RH-PAT index, and Foot-tcPO 2 /Chest-tcPO 2 ratio were significantly higher after the exercises than before (P < 0.05, P < 0.01, and P < 0.05, respectively). There was no significant difference in the LF/HF ratio measured before and after stretching exercises. These findings demonstrate that stretching exercises improve vascular endothelial function and peripheral circulation in patients with acute myocardial infarction. (Int Heart J 2013; 54: 59-63)

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“…Outros estudos já haviam comprovado uma melhora na função endotelial independente do tipo de treinamento (aeróbio, resistido ou combinado -aeróbio e resistido), do tempo empregado (um mês, três meses ou seis meses) e independente se a execução do treinamento foi realizada com instruções para a realização de exercícios em casa (home-based cardiac rehabilitation) ou se em um centro de reabilitação cardíaca convencional 4,20 . Vona et al 4 relatam que os benefícios na função endotelial vascular periférica adquiridos no treinamento podem ser perdidos em apenas um mês cessado o treinamento.…”

Section: Resultsunclassified

“…Entretanto, programas de reabilitação cardíaca são aceitos como uma intervenção terapêutica não farmacológica para o tratamento de pacientes após infarto agudo do miocárdio e/ou que foram submetidos à CRM 19 , além de melhorar a função endotelial na circulação coronária 20 e periférica 4,21,22 . Em associação, ambos os tratamentos podem ajudar a diminuir as taxas de morbidade e mortalidade destes pacientes.…”

Section: Discussionunclassified

“…Recentemente, ensaios clínicos randomizados relataram a eficácia de programas de reabilitação cardíaca (PRC) independentemente do formato dos exercícios: aeróbicos, resistidos ou combinados em pacientes com doenças coronarianas 3,4 ; ainda em outros estudos foram investigados os efeitos do PRC sobre a função vascular endotelial em pacientes com doença coronariana estável 5 , doença cardíaca isquêmi-ca 6 , infarto agudo do miocárdio e doença cardíaca crônica 3,7,8 , porém não há estudos que investigaram a função vascular endotelial em pacientes que participaram de PRC após recente CRM.…”

Section: Introductionunclassified

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Efeitos Do Treinamento Físico No Endotélio Após Cirurgia De Revascularização

Aikawa

Signori

Hauck

et al. 2015

Rev Bras Med Esporte

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RESUMOIntrodução: A cirurgia de revascularização do miocárdio (CRM) é uma das mais frequentes cirurgias realizadas em todo o mundo, muitos estudos vêm relatando os benefícios do treinamento físico para a melhora da capacidade funcional, porém há poucos estudos sobre os efeitos na função endotelial vascular. Objetivo: Analisar os efeitos do treinamento físico sobre a função endotelial vascular em pacientes submetidos à CRM, isoladamente na fase tardia da reabilitação após seis meses de programa de reabilitação cardíaca (PCR). Mé-todos: Foram incluídos pacientes que haviam sido submetidos à CRM no período máximo de um ano após a cirurgia. O PRC foi empregado durante seis meses consecutivos, com três sessões semanais. Todos os pacientes realizaram exames laboratoriais, teste de força muscular de uma repetição máxima (1-RM) para os membros superiores e inferiores, teste de caminhada de 6 min (TC6M) e avaliação da função endotelial através da técnica de vasodilatação mediada pelo fluxo. Resultados: Onze pacientes iniciaram o PRC, porém nove pacientes o completaram. A média de idade foi de 66 anos (50 a 82 anos) e o sexo masculino foi predominante (55,6%). Houve mudanças significativas nos exames laboratoriais bioquímicos: aumento do colesterol total (Basal: 162 ± 31mg/dL vs. 195 ± 39mg/dL; P=0,012) e diminuição da hemoglobina glicada (Basal: 6,74 ± 1,64% vs. 6,26 ± 1,62%; P=0,028). A força muscular aumentou significativamente nos membros superiores e inferiores (P=0,030 e P=0,038, respectivamente); no TC6M observou-se um aumento significativo de 20% na distância percorrida (P=0,020) após seis meses consecutivos de treinamento e houve uma melhora na vasodilatação mediada pelo fluxo (Basal: 6,35 ± 3,92% vs. 6 meses: 9,90 ± 4,19%; P=0,026). Conclusão: O treinamento combinado realizado em seis meses ajudou a melhorar a função endotelial e a capacidade funcional de pacientes sedentários que foram submetidos à CRM na fase tardia da reabilitação.Palavras-chave: exercício, endotélio vascular, ponte de artéria coronária, revascularização miocárdica. (6.35 ± 3.92% vs. 9.90 ± 4.19%; P=0.026 ABSTRACT Introduction: The coronary artery bypass graft surgery (CABG) is one of the most common surgeries performed worldwide, many studies have reported the benefits of physical training to improve functional capacity, however there are few studies about the effect of this training on vascular endothelial function. Objective: To analyze the effects of physical training on vascular endothelial function in patients who underwent CABG surgery alone in the last phase of rehabilitation after six months of cardiac rehabilitation program (CRP

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Effects of Different Types of Exercise Training Followed by Detraining on Endothelium-Dependent Dilation in Patients With Recent Myocardial Infarction

Cited by 128 publications

References 39 publications

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Physical activity as the main therapeutic tool for metabolic syndrome in childhood

Stretching Exercises Enhance Vascular Endothelial Function and Improve Peripheral Circulation in Patients With Acute Myocardial Infarction

Efeitos Do Treinamento Físico No Endotélio Após Cirurgia De Revascularização

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