Effects of duration and number of symptoms on vision-related anxiety in patients with Inherited Retinal Diseases

Popova, Lilia; Abuzaitoun, Rebhi; Abalem, Maria Fernanda; Andrews, Chris; Mondul, Alison M.; Lacy, Gabrielle D.; Musch, David C.; Jayasundera, Thiran

doi:10.1080/13816810.2022.2144901

Cited by 3 publications

(9 citation statements)

References 94 publications

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“…The signi cant correlations found in our study between self-perceived visual disability and vision-related anxiety are consistent with previous studies with IRD patients by Jayasundera et al and Popova et al [13,14]. Furthermore, our ndings suggesting a stronger correlation of scotopic function with rod-function anxiety, and central vision with cone-function anxiety, correspond to the results presented by Popova et al [13].…”

Section: Discussionsupporting

confidence: 93%

“…Furthermore, they inferred from RP studies that XLRP ought to be associated with a greater burden than other forms of RP, with a greater impact on patients' mental health due to the younger age of those affected and more rapid progression to advanced disease [12]. The signi cant correlations found in our study between self-perceived visual disability and vision-related anxiety are consistent with previous studies with IRD patients by Jayasundera et al and Popova et al [13,14]. Furthermore, our ndings suggesting a stronger correlation of scotopic function with rod-function anxiety, and central vision with cone-function anxiety, correspond to the results presented by Popova et al [13].…”

Section: Discussionsupporting

confidence: 91%

“…The Michigan Retinal Degeneration Questionnaire (MRDQ) and the Michigan Vision-Related Anxiety Questionnaire (MVAQ) are two psychometrically validated PRO measures speci cally designed for IRDs [15,16]. The MRDQ and MVAQ were developed using item response theory, factor analysis, and graded response models [3,13]. MRDQ measures the impact of visual impairment in daily tasks, containing 59 Likert-scaled question items across seven different dimensions: central vision, color vision, contrast sensitivity, scotopic function, photopic peripheral vision, mesopic peripheral vision, and photosensitivity [3,15].…”

Section: Methodsmentioning

confidence: 99%

“…MRDQ measures the impact of visual impairment in daily tasks, containing 59 Likert-scaled question items across seven different dimensions: central vision, color vision, contrast sensitivity, scotopic function, photopic peripheral vision, mesopic peripheral vision, and photosensitivity [3,15]. On the other hand, MVAQ is a 14-item instrument with two domains: rod-function related anxiety, which included items like worrying about bumping into people/objects or walking on uneven ground at night, and cone-function related anxiety, with items such as worrying when reading or distinguishing colors [13,16]. Item response theory analysis results in a theta score, which represents the functional ability or anxiety of a person in the measured domain [3].…”

Section: Methodsmentioning

confidence: 99%

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Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Gouveia,

Chukwunalu,

Oliveira

et al. 2024

Preprint

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Variants in the retinitis pigmentosa GTPase regulator (RPGR) gene are responsible for the majority of X-linked retinitis pigmentosa cases, which not only affects male patients but also some heterozygous females. Vision-related disability and anxiety of patients with RPGR-associated retinal degeneration have never been explored before. This study aimed to evaluate self-reported visual function and vision-related anxiety in a Portuguese cohort of male and female patients with RPGR-associated retinal degeneration using two validated patient-reported outcome measures. Cross-sectional data of thirty-two genetically-tested patients was examined, including scores of the Michigan Retinal Degeneration Questionnaire (MRDQ) and Michigan Vision-related Anxiety Questionnaire (MVAQ). Patients were classified according to retinal phenotypes in males (M), females with male phenotype (FM), and females with radial or focal pattern (FRF). Both M and FM revealed higher rod-function and cone-function anxiety scores (p < 0.017). Most MRDQ disability scores were higher in M and FM (p < 0.004). Overall, positive correlations (p < 0.004) were found between every MRDQ domain and both anxiety scores. In RPGR-associated retinal degeneration, males and females with male phenotype show similar levels of increased vision-related anxiety and disability. Every MRDQ visual function domain showed a strong correlation with anxiety scores.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Gouveia,

Chukwunalu,

Oliveira

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The inexorable vision impairment associated with IRD may profoundly impact a patient’s quality-of-life (QoL), leading to higher rates of depression and anxiety 12 , 13 . Studies have shown that vision-related anxiety correlates with disability in this population 14 .…”

Section: Introductionmentioning

confidence: 99%

Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Gouveia,

Chukwunalu,

Oliveira

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Variants in the retinitis pigmentosa GTPase regulator (RPGR) gene are responsible for the majority of X-linked retinitis pigmentosa cases, which not only affects male patients but also some heterozygous females. Vision-related disability and anxiety of patients with RPGR-associated retinal degeneration have never been explored before. This study aimed to evaluate self-reported visual function and vision-related anxiety in a Portuguese cohort of male and female patients with RPGR-associated retinal degeneration using two validated patient-reported outcome measures. Cross-sectional data of thirty-two genetically-tested patients was examined, including scores of the Michigan retinal degeneration questionnaire (MRDQ) and Michigan vision-related anxiety questionnaire. Patients were classified according to retinal phenotypes in males (M), females with male phenotype (FM), and females with radial or focal pattern. Both M and FM revealed higher rod-function and cone-function anxiety scores (p < 0.017). Most MRDQ disability scores were higher in M and FM (p < 0.004). Overall, positive correlations (p < 0.004) were found between every MRDQ domain and both anxiety scores. In RPGR-associated retinal degeneration, males and females with male phenotype show similar levels of increased vision-related anxiety and disability. Every MRDQ visual function domain showed a strong correlation with anxiety scores.

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Positive feedback loop between vision-related anxiety and self-reported visual difficulty

Popova

Abuzaitoun

Fresco

et al. 2023

Ophthalmic Genetics

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Effects of duration and number of symptoms on vision-related anxiety in patients with Inherited Retinal Diseases

Cited by 3 publications

References 94 publications

Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Exploring self-reported visual function and vision-related anxiety in patients with RPGR-associated retinal degeneration

Positive feedback loop between vision-related anxiety and self-reported visual difficulty

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