Effects of Electroacupuncture on Overactive Bladder Refractory to Anticholinergics: A Single-Blind Randomised Controlled Trial

Zhang, Jie; Cheng, Wei-Ming; Cai, Mingming

doi:10.1136/acupmed-2015-010770

Cited by 17 publications

(47 citation statements)

References 22 publications

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“… 32 Qin et al reported that MA could inhibit bladder motility in the active state and enhance bladder motility in the static state, 33 while in some studies BL33 has been used to suppress an overactive bladder (OAB). 34 In our previous study, we observed the inhibitory effects of EA in a rat model of OAB syndrome. 35 However, when we used acupuncture as an intervention in UR rats, we found that acupuncture could also enhance bladder activity.…”

Section: Discussionmentioning

confidence: 91%

Effects of Electroacupuncture at Bl33 on Detrusor Smooth Muscle Activity in a Rat Model of Urinary Retention

Liu

Zhi

et al. 2017

Acupunct Med

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BackgroundDetrusor smooth muscle (DSM) underactivity may lead to urinary retention (UR). Electroacupuncture (EA) at BL33 may be effective in improving DSM contractions.ObjectivesThis study aimed to investigate: (1) the effect of EA at BL33; and (2) the effect of different manipulation methods at BL33 on the modulation of DSM contractions in UR rats.Methods30 male Sprague-Dawley rats were anaesthetised with urethane and modelled by urethral outlet obstruction. First, 2 Hz EA at BL33, SP6 and LI4 wasrandomly applied to the UR rats for 5 min to observe the immediate effects (n=10); second, manual acupuncture (MA) (n=10) and 100 Hz EA (n=10) were applied with the same programme. DSM electromyography (EMG) and cystometrogram data were evaluated.Results(1) 2 Hz EA at BL33 and SP6 significantly increased DSM discharging frequency (0.80±0.10 Hz, P<0.001, and 0.22±0.14 Hz, P=0.038), shortened micturation intervals (65.67±20.65 s, P=0.008, and 35.62±15.84 s, P=0.042), prolonged the duration of voiding (2.13±0.61 s, P=0.005, and 0.47±0.16 s, P=0.015), and reduced residual pressure (−0.91±0.31 mmHg, P=0.019, and −0.66±0.27 mmHg, P=0.046). EA at LI4 was not associated with any functional effects (P>0.05). Compared with SP6, EA at BL33 had greater positive effects on DSM discharging frequency, duration of discharging, and duration of voiding (all P<0.05). (2) No statistically significant differences were shown between MA, 2 Hz EA and 100 Hz EA interventions when stimulating at BL33, SP6 or LI4.ConclusionsEA at BL33 improved DSM contractions to a greater degree than EA at SP6 or LI4. There were no differences in effect when stimulating using 2 Hz EA, 100 Hz EA and MA.

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Section: Discussionmentioning

confidence: 91%

Effects of Electroacupuncture at Bl33 on Detrusor Smooth Muscle Activity in a Rat Model of Urinary Retention

Liu

Zhi

et al. 2017

Acupunct Med

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“…Finally, 10 studies met all the inclusion criteria. [ 24 – 33 ] Except for 2 studies in English, [ 31 , 32 ] the other 8 studies were reported in Chinese. [ 24 – 30 , 33 ] The study screening and a summary of the included studies are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A majority of acupuncturists chose acupuncture points depending on the theory of Chinese medicine and their clinical experience. EA was used in nine studies, [ 24 – 30 , 32 , 33 ] and manual needle stimulation was performed in one trial. [ 31 ] Sanyinjiao (SP6), Pangguangshu (BL28), Ciliao (BL32), Taixi (KI3), and Shenshu (BL23) were the most commonly used points.…”

Section: Resultsmentioning

confidence: 99%

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Acupuncture for adults with overactive bladder

Zhao

Zhou

et al. 2018

Medicine

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Background:Overactive bladder is stated as the occurrence of urinary urgency which will cause negative impacts and decrease patients’ health-related quality of life. The aim of this systematic review is to assess the efficiency and safety of acupuncture for adults with overactive bladder (OAB) comparing with sham-acupuncture, drugs, and acupuncture plus drugs.Methods:We independently searched 9 databases from beginning to August 15, 2017. Two writers extracted data at the same time independently. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (CIs) and mean difference (MD) with 95% CIs.Results:Ten randomized controlled trials (RCTs) with 794 patients were included in this systematic review. The combined results showed that electroacupuncture (EA) may be more effective than sham electroacupuncture (sham EA) in improving the 24-hour nocturia episodes and EA may enhance tolterodine for relieving voiding symptoms and enhancing patients’ quality of life. However, more trials with high quality and larger sample sizes will be needed in the future to provide sufficient evidence. Only 15 of 794 OAB patients from the included studies reported mild adverse reactions related to EA, therefore, acupuncture is safe for treating OAB.Conclusion:Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes. However, the evidence is insufficient to show the effect using acupuncture alone or the additional effect to drugs in treating OAB.

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“…To assess the efect of acupuncture objectively, urodynamics were used to measure patients' bladder function at baseline and postreatment. After 6-week treatment, a signiicant improvement in the irst sensation of bladder illing, irst urge to void and maximum cystometric capacity were observed in electro-acupuncture group, while no change in control group [39]. In another randomized, controlled trail, 199 patients with UUI were assigned into electro-acupuncture or pharmacological therapy group with a ratio of 2:1.…”

Section: Uuimentioning

confidence: 99%

Complementary and Alternative Medicine Treatment for Urinary Incontinence

Pang¹,

Chang²,

Zhou³

et al. 2017

Synopsis in the Management of Urinary Incontinence

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Complementary and alternative medicine has been widely used for various diseases and gained acceptance throughout the industrialized world. Basically, complementary and alternative medicine is grouped into ive domains: biologically based therapies, mind-body interventions, manipulative and body-based approaches, energy therapies and whole medical systems. Each domain covers a number of therapies. In this chapter, we present the evidence about efectiveness of each complementary and alternative medicine therapy as well as the possible mechanism on the treatment of urinary incontinence. Besides reviewing existed evidence, our research and clinical experience are also presented.

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Effects of Electroacupuncture on Overactive Bladder Refractory to Anticholinergics: A Single-Blind Randomised Controlled Trial

Abstract: EA appears to be an effective, safe and minimally invasive treatment for women with OAB. Further studies with longer follow-up are needed to evaluate whether it could be a therapeutic option for OAB refractory to treatment with anticholinergics.

Cited by 17 publications

References 22 publications

Effects of Electroacupuncture at Bl33 on Detrusor Smooth Muscle Activity in a Rat Model of Urinary Retention

Effects of Electroacupuncture at Bl33 on Detrusor Smooth Muscle Activity in a Rat Model of Urinary Retention

Acupuncture for adults with overactive bladder

Complementary and Alternative Medicine Treatment for Urinary Incontinence

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