Effects of electroacupuncture with different frequencies on spinal ionotropic glutamate receptor expression in complete Freund's adjuvant-injected rat

Choi, Byung-Tae; Kang, Jin Suk; Jo, Un-Bock

doi:10.1016/j.acthis.2004.07.008

Cited by 36 publications

(17 citation statements)

References 19 publications

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“…83,84 In a CFA-induced pain model, studies show that electroacupuncture at 2, 15, or 120 HZ not only significantly alleviates CFA-induced mechanical hyperalgesia but also significantly decreases CFA-upregulated GluN1, GluN2A, and GluA1 in the spinal dorsal horn. 85 In dorsal root ganglia (DRG), alternation of 4 and 16 Hz electroacupuncture at GB30 and GB34 significantly inhibited CFA-induced GluN1 upregulation. 86 In our studies, 10 Hz electroacupuncture at GB30 significantly decreased CFA-enhanced GluN1 phosphorylation.…”

Section: Inflammatory Pain Animal Modelsmentioning

confidence: 99%

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Zhang

Lao

Ren³

et al. 2014

Anesthesiology

648

465

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In the last decade, preclinical investigations of electroacupuncture mechanisms on persistent tissue-injury (inflammatory), nerve-injury (neuropathic), cancer, and visceral pain have increased. These studies show that electroacupuncture activates the nervous system differently in health than in pain conditions, alleviates both sensory and affective inflammatory pain, and inhibits inflammatory and neuropathic pain more effectively at 2–10 Hz than at 100 Hz. Electroacupuncture blocks pain by activating a variety of bioactive chemicals through peripheral, spinal, and supraspinal mechanisms. These include opioids, which desensitize peripheral nociceptors and reduce pro-inflammatory cytokines peripherally and in the spinal cord, and serotonin and norepinephrine, which decrease spinal n-methyl-d-aspartate receptor subunit GluN1 phosphorylation. Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management that can forestall the side effects of often-debilitating pharmaceuticals.

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Section: Inflammatory Pain Animal Modelsmentioning

confidence: 99%

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Zhang

Lao

Ren³

et al. 2014

Anesthesiology

648

465

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“…Choi et al 34 studied the effects of three frequencies of EA (2, 15, and 120 Hz) on chemically induced inflammation of the rat hindpaw. These investigators found that the edema and mechanical sensitivity of rats' hindpaws were strongly inhibited by EA through modulating expression of ionotropic glutamate receptors, particularly Nmethyl-d-aspartate receptor in the dorsal horn of the spinal cord.…”

Section: Experimental Datamentioning

confidence: 99%

Acupuncture Analgesia: I. The Scientific Basis

Wang¹,

Kain²,

White³

2008

Anesthesia &Amp; Analgesia

232

122

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Acupuncture has been used in China and other Asian countries for the past 3000 yr. Recently, this technique has been gaining increased popularity among physicians and patients in the United States. Even though acupuncture-induced analgesia is being used in many pain management programs in the United States, the mechanism of action remains unclear. Studies suggest that acupuncture and related techniques trigger a sequence of events that include the release of neurotransmitters, endogenous opioid-like substances, and activation of c-fos within the central nervous system. Recent developments in central nervous system imaging techniques allow scientists to better evaluate the chain of events that occur after acupuncture-induced stimulation. In this review article we examine current biophysiological and imaging studies that explore the mechanisms of acupuncture analgesia.

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“…[74][75][76][77][78][79] In the inflammatory reflex of the autonomous nervous system (ANS), acupuncture can harmonise ANS and suppress inflammation for analgesia. [80][81][82][83][84][85] With respect to the hypothalamic-pituitary-adrenal axis, the ANS and the descending inhibitory pathway, acupuncture should be considered as a viable option in the management of these patients. In this respect, future trials should adhere to rigorous trial designs that are suitable for the research questions being addressed.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture for primary dysmenorrhoea: a systematic review

Cho

2010

BJOG

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Background The effectiveness of acupuncture in primary dysmenorrhoea is not fully understood.Objectives To assess the effectiveness of acupuncture for the symptomatic treatment of primary dysmenorrhoea from randomised controlled trials (RCTs).Search strategy Nineteen electronic databases, including English, Korean, Japanese and Chinese databases, were systematically searched for RCTs investigating acupuncture for primary dysmenorrhoea up to July 2008 with no language restrictions.Selection criteria All RCTs that evaluated the effects of acupuncture compared with controls were included. Studies that assessed the effect of moxibustion or body acupressure were excluded.Data collection and analysis The study abstraction and quality assessment of all studies were undertaken following the detailed descriptions of these categories as described in the Cochrane Handbook for Systematic Reviews of Interventions.Main results Twenty-seven RCTs were systematically reviewed. Only nine of the 27 trials clearly described their methods of randomisation and none of the trials stated the methods of allocation concealment. Compared with pharmacological treatment or herbal medicine, acupuncture was associated with a significant reduction in pain. Three studies reported reduced pain within groups from baseline; however, two RCTs did not find a significant difference between acupuncture and sham acupuncture.Author's conclusions The review found promising evidence in the form of RCTs for the use of acupuncture in the treatment of primary dysmenorrhoea compared with pharmacological treatment or herbal medicine. However, the results were limited by methodological flaws. The evidence for the effectiveness of acupuncture for the treatment of primary dysmenorrhoea is not convincing compared with sham acupuncture. Further rigorous nonpenetrating placebo-controlled RCTs are warranted.

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Effects of electroacupuncture with different frequencies on spinal ionotropic glutamate receptor expression in complete Freund's adjuvant-injected rat

Cited by 36 publications

References 19 publications

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

Acupuncture Analgesia: I. The Scientific Basis

Acupuncture for primary dysmenorrhoea: a systematic review

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