Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitis

Yoo, Frederick; Schlosser, Rodney J.; Storck, Kristina A.; Ganjaei, Kimia G.; Rowan, Nicholas R.; Soler, Zachary M.

doi:10.1002/alr.22406

Cited by 22 publications

(28 citation statements)

References 47 publications

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“…Several studies have shown a correlation between the presence of pro-inflammatory molecules and cognitive dysfunction [3][4][5]. Existing hypotheses postulate an individual effect of particular inflammatory mediators on cognitive function in CRS with or without nasal polyposis [2]. Referring to this study [2], the inflammatory cascade might impact cognition.…”

Section: Introductionmentioning

confidence: 68%

“…Existing hypotheses postulate an individual effect of particular inflammatory mediators on cognitive function in CRS with or without nasal polyposis [2]. Referring to this study [2], the inflammatory cascade might impact cognition.…”

Section: Introductionmentioning

confidence: 74%

“…More than 10% of the adult population suffers from chronic rhinosinusitis (CRS) and up to 25% of the cases are associated with nasal polyposis [1]. Interestingly, CRS seems to be associated with cognitive dysfunction [2] as shown by cognitive assessment tests, e.g., the Cognitive Failure Questionnaire and the Automated Neuropsychological Assessment Metrics platform [2]. Pro-inflammatory molecules might be the main link between cognitive dysfunction and CRS [2].…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, CRS seems to be associated with cognitive dysfunction [2] as shown by cognitive assessment tests, e.g., the Cognitive Failure Questionnaire and the Automated Neuropsychological Assessment Metrics platform [2]. Pro-inflammatory molecules might be the main link between cognitive dysfunction and CRS [2]. A higher level of stress as assumed for patients with CRS and nasal polyposis might influence the severity of cognitive dysfunction negatively [2].…”

Section: Introductionmentioning

confidence: 99%

“…Pro-inflammatory molecules might be the main link between cognitive dysfunction and CRS [2]. A higher level of stress as assumed for patients with CRS and nasal polyposis might influence the severity of cognitive dysfunction negatively [2]. Several studies have shown a correlation between the presence of pro-inflammatory molecules and cognitive dysfunction [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis

et al. 2020

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Background Chronic rhinosinusitis may be associated with nasal polyposis. Recurrence of disease is often observed and may be due to an intolerance of acetylsalicylic acid. Sex hormones are known to modulate allergic reactions and inflammation. Whether they may be involved in the development and progression of nasal polyposis has not been investigated yet. Aim Examine the relationship between levels of sex hormones and nasal polyposis. Methods Hormonal levels (estradiol, testosterone and progesterone) in patients with nasal polyposis (n = 26) with or without acetylsalicylic acid-intolerance were determined and compared to hormonal levels in patients with septal deviation (n = 35). Cone-beam computed tomography scans were analysed by using scores as defined by Lund and Mackay and by Kennedy. Results Our results show a 5 times greater odds (p = 0.01) for developing nasal polyposis in the presence of lowered estradiol plasma levels than in the presence of normal / elevated levels. When analyzing females and males separately, a 6 times greater odds for females to develop nasal polyposis in the presence of lowered estradiol plasma levels was calculated (p = 0.02). Thus, females are more likely to develop nasal polyposis when they have lowered estradiol levels than males. In addition, female patients showed an increased risk for developing ASA intolerance (p = 0.01). Conclusion Variation of sex hormones may be involved in nasal polyposis. Further studies including more patients to validate the presented results are required. Significance Retrospective clinical investigation suggesting a correlation between varying sex hormones and nasal polyposis.

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Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis

et al. 2020

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Rhinologic and skull‐base surgery: an evidence‐based reevaluation

Kennedy¹

2019

Int Forum Allergy Rhinol

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Rhinologic disease and its impact on sleep: a systematic review

Fried

Yuen

et al. 2020

Int Forum Allergy Rhinol

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Background Rhinologic disease can be responsible for systemic symptoms affecting mood, cognition, and sleep. It is unclear whether sleep disturbance in specific rhinologic disorders (chronic rhinosinusitis [CRS], rhinitis, and nasal septal deviation [NSD]) is an obstructive phenomenon or due to other mechanisms. In this review we examine the impact of CRS, rhinitis, and NSD on objective and subjective sleep outcome metrics and draw comparisons to normal controls and patients with known obstructive sleep apnea (OSA). Methods A systematic review of 4 databases (PubMed, Scopus, Cochrane Library, and Web of Science) was performed. Studies reporting on objective (apnea‐hypopnea index [AHI], respiratory disturbance index [RDI], oxygen nadir) and subjective (Epworth Sleepiness Scale [EpSS], Pittsburgh Sleep Quality Index [PSQI], Fatigue Severity Scale [FSS]) sleep parameters and disease‐specific patient‐reported outcome measures (PROMs; 22‐item Sino‐Nasal Outcome Test [SNOT‐22], Rhinoconjunctivitis Quality of Life Questionnaire [RQLQ], Nasal Obstruction Symptom Evaluation [NOSE]) were included. Results The database search yielded 1414 unique articles, of which 103 were included for analysis. Baseline PROMs were at the high end of normal to abnormal for all 3 conditions: EpSS: CRS (9.8 ± 4.0), rhinitis (9.7 ± 4.3), and NSD (8.9 ± 4.6); and PSQI: CRS (11.0 ± 4.5), rhinitis (6.1 ± 3.7), and NSD (8.6 ± 3.5). Objective measures demonstrated a mild to moderate OSA in the studied diseases: AHI: CRS (10.4 ± 11.5), rhinitis (8.6 ± 8.8), and NSD (13.0 ± 6.9). There were significant differences when compared with reported norms in all measured outcomes (p < 0.001). Conclusion Sleep quality is impacted by rhinologic (CRS, rhinitis, NSD) disease. There is likely a mild obstructive component contributing to poor sleep, but other contributing factors may be involved.

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Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitis

Cited by 22 publications

References 47 publications

Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis

Level of sex hormones and their association with acetylsalicylic acid intolerance and nasal polyposis

Rhinologic and skull‐base surgery: an evidence‐based reevaluation

Rhinologic disease and its impact on sleep: a systematic review

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