Effects of engineered nanoparticles on the innate immune system

Liu, Yuanchang; Hardie, Joseph; Zhang, Xianzhi; Rotello, Vincent M.

doi:10.1016/j.smim.2017.09.011

Cited by 230 publications

(151 citation statements)

References 106 publications

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“…The immune system and cancer progression have a complex relationship. While effective immune-based strategies are of interest in enervating and eliminating cancer progression, their development can be challenging due to varying macrophageactivating signals [29,30]. PBI1 has significant macrophage activation capability.…”

Section: Resultsmentioning

confidence: 99%

Macrophage Activation by a Substituted Pyrimido[5,4-b]Indole Increases Anti-Cancer Activity

Hardie

Mas-Rosario²,

et al. 2019

Preprint

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Immunotherapy has become a promising new approach for cancer treatment due to the immune system's ability to remove tumors in a safe and specific manner. Many tumors express anti-inflammatory factors that deactivate the local immune response or recruit peripheral macrophages into pro-tumor roles. Because of this, effective and specific ways of activating macrophages into anti-tumor phenotypes is highly desirable for immunotherapy purposes. Here, the use of a small molecule TLR agonist as a macrophage activator for anti-cancer therapy is reported. This compound, referred to as PBI1, demonstrated unique activation characteristics and expression patterns compared to treatment with LPS, through activation of TLR4. Furthermore, PBI1 treatment resulted in anti-tumor immune behavior, enhancing macrophage phagocytic efficiency five-fold versus non-treated macrophages. Additive effects were observed via use of a complementary strategy (anti-CD47 antibody), resulting in ~10-fold enhancement of phagocytosis, suggesting this small molecule approach could be used in conjunction with other therapeutics. 1 2

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Section: Resultsmentioning

confidence: 99%

Macrophage Activation by a Substituted Pyrimido[5,4-b]Indole Increases Anti-Cancer Activity

Hardie

Mas-Rosario²,

et al. 2019

Preprint

Self Cite

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“…Jun D and Ben ZT et al. ( 38 ) efficiently made fluorogen TTB with AIE properties encapsulated within a polymeric matrix and modified with RGD-4R peptide to prepare RGD-4R-MPD/TTB NPs with NIR emission, high photostability, and low dark cell toxicity. The results show that the PDT based on RGD-4R-MPD/TTB NPs T can effectively inhibit the growth of cervical, prostatic, and ovarian cancer.…”

Section: The Latest Developments and Biomedical Applications Of Aie Mmentioning

confidence: 99%

Immunological Effects of Aggregation-Induced Emission Materials

Huang

Zhou

et al. 2020

Front. Immunol.

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Nanotechnology is widely used in the fields of biology and medicine. Some special nanoparticles with good biocompatibility, hydrophilicity, and photostability can be used as ideal systems for biomedical imaging in early diagnosis and treatment of diseases. Among them, aggregation-induced emission materials are new antiaggregation-caused quenching nano-imaging materials, which have advantages in biocompatibility, imaging contrast, and light stability. Meanwhile, heterogeneity of nanoparticles may cause various adverse immune reactions. In response to the above problems, many researchers have modified nano-materials to be multifunctional nano-composites, aiming at combining diagnosis and treatment with simultaneous imaging and targeted therapy and additionally avoiding immune reactions, which is of great potential in imaging-guided therapy. This review discusses the application of aggregation-induced emission materials, and other nano-imaging materials are also mentioned. We hope to provide new ideas and methods for the imaging of nano-materials in diagnosis and treatment.

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“…Such analyses rely basically on cancer cell lines, normal cell lines or primary cells maintained in standard and controlled conditions, namely a definite time period, certain cellular concentrations, level of cellular confluency, etc. (Liu et al 2017). The principal benefit for chemical effect assessment is that cellular responses noticed through in vitro cell cultures can be evaluated, whereas in vivo models might be disturbed by "non-chemical stressors" that can interfere with the real studied effects (Bopp et al 2015).…”

Section: In Vitro Approachesmentioning

confidence: 99%

Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures

et al. 2019

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Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as the route, concentration, duration, and the timing of exposure when determining toxicity to the organism. The need for adequate model systems (in vivo, in vitro, in silico and mathematical) is paramount for better understanding of chemical mixture toxicity. Currently, shortcomings plague each model system as investigators struggle to find the appropriate balance of rigor, reproducibility and appropriateness in mixture toxicity studies. Significant questions exist when comparing single-to mixture-chemical toxicity concerning additivity, synergism, potentiation, or antagonism. Dose/concentration relevance is a major consideration and should be subthreshold for better accuracy in toxicity assessment. Previous work was limited by the technology and methodology of the time, but recent advances have resulted in significant progress in the study of mixture toxicology. Novel technologies have added insight to data obtained from in vivo studies for predictive toxicity testing. These include new in vitro models: omics-related tools, organs-on-a-chip and 3D cell culture, and in silico methods. Taken together, all these modern methodologies improve the understanding of the multiple toxicity pathways associated with adverse outcomes (e.g., adverse outcome pathways), thus allowing investigators to better predict risks linked to exposure to chemical mixtures. As technology and knowledge advance, our ability to harness and integrate separate streams of evidence regarding outcomes associated with chemical mixture exposure improves. As many national and international organizations are currently stressing, studies on chemical mixture toxicity are of primary importance.

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Effects of engineered nanoparticles on the innate immune system

Cited by 230 publications

References 106 publications

Macrophage Activation by a Substituted Pyrimido[5,4-b]Indole Increases Anti-Cancer Activity

Macrophage Activation by a Substituted Pyrimido[5,4-b]Indole Increases Anti-Cancer Activity

Immunological Effects of Aggregation-Induced Emission Materials

Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures

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