Effects of enriched environment on alterations in the prefrontal cortex GFAP- and S100B-immunopositive astrocytes and behavioral deficits in MK-801-treated rats

Rahati, Maryam; Nozari, Masoumeh; Eslami, Habib; Shabani, Mohammad; Basiri, Mohsen

doi:10.1016/j.neuroscience.2016.03.065

Cited by 33 publications

(26 citation statements)

References 72 publications

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“…In relation to stress, decreased GFAP expression has been shown to occur in the brains of stressed animals (ArayaCallís, Hiemke, Abumaria, & Flugge, 2012; Imbe, Kimura, Donishi, & Kaneoke, 2013) indicating astrocyte dysfunction. Considering that astrocytes are critical in support ing neuronal functioning, astrocyte dysfunction may lead to neuronal dysfunction, particularly in stress sensitive brain regions, leading to anxietylike and depressive behaviors (Li, Yang, Ma, & Qu, 2013;Rahati, Nozari, Eslami, Shabani, & Basiri, 2016). Because GFAP expression has been found to be an important stressrelated endpoint and indicator of astrocyte function, we wanted to determine how its expression would change in response to our social stress paradigm(s).…”

Section: Are All Chronic Social Stressors the Same? Behavioral Physimentioning

confidence: 99%

The Influence of Anxiety and Self-Efficacy on Statistics Performance: A Path Analysis

Hoegler¹,

Nelson²

2018

PsiChiJournal

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ABOUT PSI CHI Psi Chi is the International Honor So ci ety in Psychology, found ed in 1929. Its mission: "recognizing and promoting excellence in the science and application of psy chol ogy." Mem ber ship is open to undergraduates, graduate students, faculty, and alumni mak ing the study of psy chol ogy one of their major interests and who meet Psi Chi's min i mum qual i fi ca tions. Psi Chi is a member of the As so cia tion of Col lege Honor So ci et ies (ACHS), and is an affiliate of the Ameri can Psy cho logi cal As so cia tion (APA) and the Association for Psy cho log i cal Science (APS). Psi Chi's sister honor society is Psi Beta, the na tion al honor society in psychology for com mu nity and junior colleges. Psi Chi functions as a federation of chap ters located at over 1,150 senior col leg es and universities around the world. The Psi Chi Central Office is lo cat ed in Chatta nooga, Ten nessee. A Board of Directors, com posed of psy chol o gy faculty who are Psi Chi members and who are elect ed by the chapters, guides the affairs of the Or ga ni za tion and sets pol i cy with the ap prov al of the chap ters. Psi Chi membership provides two major opportunities. The first of these is ac a dem ic rec og ni tion to all in duc tees by the mere fact of mem ber ship. The sec ond is the opportunity of each of the Society's local chapters to nourish and stim u late the pro fes sion al growth of all members through fellowship and activities de signed to augment and en hance the reg u lar cur ric u lum. In addition, the Or ga ni za tion provides programs to help achieve these goals including con ven tions, research awards and grants competitions, and publication opportunities. JOURNAL PURPOSE STATEMENT The twofold purpose of the Psi Chi Journal of Psychological Research is to foster and reward the scholarly efforts of Psi Chi members, whether students or faculty, as well as to provide them with a valuable learning experience. The articles pub lished in the Journal represent the work of under graduates, graduate students, and faculty; the Journal is dedicated to increas ing its scope and relevance by accepting and involving diverse people of varied racial, ethnic, gender identity, sexual orientation, religious, and social class backgrounds, among many others. To further support authors and enhance Journal visibility, articles are now available in the PsycINFO ® , EBSCO ® , Crossref ® , and Google Scholar databases. In 2016, the Journal also became open access (i.e., free online to all readers and authors) to broad en the dissemination of research across the psychological science community.

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Section: Are All Chronic Social Stressors the Same? Behavioral Physimentioning

confidence: 99%

The Influence of Anxiety and Self-Efficacy on Statistics Performance: A Path Analysis

Hoegler¹,

Nelson²

2018

PsiChiJournal

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“…In a separate study, juvenile Sprague-Dawley rats from stressed pregnancies showed an increase in the basal circulating levels of CD4 + and CD8 + T lymphocytes, increased levels of cytokine IL-2, and reduced levels of cytokine IL-1β when housed in short-term enriched conditions at an early age (Laviola et al, 2004). EE for rodents in large cages with toys and other accessories has shown beneficial effects on brain glial cell morphology and numbers in models of several neurodegenerative and psychiatric disorders such as AD (Beauquis et al, 2013), schizophrenia (Rahati et al, 2016) and depression (Laviola et al, 2008). While abnormalities in brain glial cell morphology and functioning are the established etiologies of these psychiatric disorders (Cotter et al, 2001;Nagele et al, 2004), the effects of different EE protocols and inclusion or exclusion of EE objects on glial cells may differ in different brain regions.…”

Section: Introductionmentioning

confidence: 99%

Duration of Environmental Enrichment Determines Astrocyte Number and Cervical Lymph Node T Lymphocyte Proportions but Not the Microglial Number in Middle-Aged C57BL/6 Mice

Singhal

Morgan

Jawahar

et al. 2020

Front. Cell. Neurosci.

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Environmental enrichment (EE) has been shown to modulate behavior and immunity. We recently reported that both short and long-term EE enhance baseline locomotion and alleviate depressive-like behavior, but only long-term EE affects locomotion adversely in a threatening environment and enhances anxiety-like behavior in middle-age mice. We have now investigated whether the observed changes in behavior after short-and long-term EE were associated with underlying immune changes. Hence, at the end of behavioral testing, mice were sacrificed, and brains and cervical lymph nodes were collected to investigate the differential effects of the duration of EE (short-and long-term) on the number of immunopositive glial cells in the dentate gyrus, CA1, CA2, and CA3 regions of the hippocampus and proportions of T cell subsets in the cervical lymph nodes using immunohistochemistry and flow cytometry, respectively. EE, regardless of duration, caused an increase in microglia number within the dentate gyrus, CA1 and CA3 hippocampal regions, but only long-term EE increased astrocytes number within the dentate gyrus and CA3 hippocampal regions. A significantly higher proportion of CD8 + naive T cells was observed after long-term EE vs. short-term EE. No significant differences were observed in the proportion of central memory and effector memory T cells or early activated CD25 + cells between any of the test groups. Our results suggest that EE, irrespective of duration, enhances the numbers of microglia, but long-term EE is required to modify astrocyte number and peripheral T cell proportions in middle-aged mice. Our findings provide new insights into the therapeutic effects of EE on various brain disorders, which may be at least partly mediated by glial and neuroimmune modulation.

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“…GFAP is one of the main immunocytochemical markers of astrocytes, the most important representative of microglia in the CNS of mammals [3,4]. Protein S-100 is a specific protein for the cells of the astrocytic glory of the CNS, and the NSE is an intracellular cytoplasmic enzyme of the neurons that catalyzes the transformation of 2-phosphoglycerate to 2-phosphoenolpyruvate [5]. It is widely used for diagnostic purposes and in experimental works in the study of the functions of the nervous system in norm and in pathology as a marker of astrocytes [5,6].…”

mentioning

confidence: 99%

“…Cerebrospinal fluid MBP levels increase in acute demyelination [8,9]. Thus, the diagnostic and prognostic value of increasing of NSE, the MBP, GFAP, BDNF, S-100 protein levels in stroke, craniocerebral trauma, and CNS defects in newborns has been proven [4][5][6][7][8][9][10]. During viral neuroinfections, damage to the cells of the brain occurs, and determining of the levels of neuro-specific markers may have a diagnostic value.…”

mentioning

confidence: 99%

Діагностичне Значення Нейроспецифічних Маркерів Nse, S-100, Gfap, MBP І BDNF У Цереброспінальній Рідині Хворих На Вірусний Менінгіт

Kozko¹,

Сохань²,

Burma³

2018

ІХ

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Мета роботи – визначити діагностичну цінність рівнів нейроспецифічних маркерів NSE, GFAP, S–100, MBP та BDNF у ЦСР дорослих хворих на вірусні менінгіти.Пацієнти і методи. Для дослідження були залучені 50 пацієнтів з вірусними менінгітами віком від 18 до 65 років. Пацієнти з менінгітом, що викликаний вірусом простого герпесу 1,2, склали 1-у групу (n=21), з Епштейна-Барр менінгітом − 2-у групу (n=19), з ентеровірусним менінгітом – 3-ю групу дослідження (n=10). Рівень нейроспецифічних маркерів визначався у ЦСР хворих на першу та 10-12-у добу лікування за допомогою методу ІФА.

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Effects of enriched environment on alterations in the prefrontal cortex GFAP- and S100B-immunopositive astrocytes and behavioral deficits in MK-801-treated rats

Cited by 33 publications

References 72 publications

The Influence of Anxiety and Self-Efficacy on Statistics Performance: A Path Analysis

The Influence of Anxiety and Self-Efficacy on Statistics Performance: A Path Analysis

Duration of Environmental Enrichment Determines Astrocyte Number and Cervical Lymph Node T Lymphocyte Proportions but Not the Microglial Number in Middle-Aged C57BL/6 Mice

Діагностичне Значення Нейроспецифічних Маркерів Nse, S-100, Gfap, MBP І BDNF У Цереброспінальній Рідині Хворих На Вірусний Менінгіт

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