Effects of essential amino acids on lipid metabolism in mice and humans

Xiao, Fei; Du, Ying; Lv, Ziquan; Chen, Shanghai; Zhu, Jie; Guo, Feifan

doi:10.1530/jme-16-0116

Cited by 29 publications

(30 citation statements)

References 30 publications

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“…Additionally, tryptophan is significantly upregulated in SW compared with the serum tryptophan levels of DW. It has been suggested that people with obesity are prone to having higher levels of tryptophan (23,24), which provides evidence concerning the association between shift work and metabolic obesity. Tryptophan metabolites, such as serotonin (5-HT), kynurenine, and melatonin, play an important part in lipid metabolism, caloric intake, and sleep-wake cycle regulation.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Profiles of Shift Workers and Day Workers: A Cross‐Sectional Study

Huang

Chen

Zhao

et al. 2021

Obesity

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Objective The purpose of this study was to characterize the metabolomic profiles of shift workers and day workers and to discover the effect of shift work on workers’ metabolic health. Methods A total of 824 participants aged 25 to 55 years were recruited, and 485 (275 shift workers and 210 day workers) completed the study. The mean age of the shift workers was 37.32 (5.53) years old, and that of day workers was 36.50 (7.83) years old. Serum and salivary samples were collected for the detection of key biochemical indicators (melatonin, cholesterol, and low‐density lipoprotein cholesterol) and for metabolome profile analyses. Results Compared with female day workers, female shift workers had a higher BMI, waist circumference, and hip circumference. Correspondingly, we identified 76 significant metabolites (false discovery rate < 0.05) in shift workers, including L‐tryptophan, acylcarnitines, and several fatty acids. Three pathways that presented significant differences were biosynthesis of unsaturated fatty acids, linoleic acid metabolism, and ubiquinone and other terpenoid‐quinone biosynthesis. Conclusions Compared with day workers, shift workers were more prone to weight gain and central obesity and were at a higher risk for impaired lipid metabolism with disrupted circadian rhythms.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Profiles of Shift Workers and Day Workers: A Cross‐Sectional Study

Huang

Chen

Zhao

et al. 2021

Obesity

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“…Branched chain amino acids include leucine, isoleucine and valine, which play an important role in protein synthesis and glucose homeostasis [18]. Research has confirmed that Valine, leucine, and isoleucine biosynthesis are involved in metabolic processes in humans and animals, and their lack in the diet for more than 7 days rapidly reduced the amount of abdominal fat in mice [14,27]. Protein digestion and absorption, mineral absorption, and the citrate cycle also affect the body's metabolism, which explains the lighter weight of the offspring exposed to antibiotics during pregnancy in our experiment, which might represent the method by which the gut microbiota to exerts biological effects via metabolites.…”

Section: S24-7 Might Affect the Weight Changes Of Offspring Through Different Metabolic Pathwaysmentioning

confidence: 99%

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

et al. 2021

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Antibiotic exposure during pregnancy will adversely affect the growth of offspring; however, this remains controversial and the mechanism is poorly understood. To study this phenomenon, we added ceftriaxone sodium to the drinking water of pregnant rats and continuously monitored the body weight of their offspring. The results showed that compared with the control group, the offspring exposed to antibiotics during pregnancy had a higher body weight up to 3 weeks old but had a lower body weight at 6 weeks old. To determine the role of the gut microbiota and its metabolites in the growth of offspring, we collected feces for sequencing and further established that the experimental group has a different composition ratio of dominant bacteria at 6 week old, among which S24–7 correlated negatively with body weight and the metabolites that correlated with body weight-related unique flora were L-Valine, L-Leucine, Glutaric acid, N-Acetyl-L-glutamate, and 5-Methylcytosine. To further explore how they affect the growth of offspring, we submitted these data to Kyoto Encyclopedia of Genes and Genomes website for relevant pathway analysis. The results showed that compared with the control, the following metabolic pathways changed significantly: Valine, leucine, and isoleucine biosynthesis; Protein digestion and absorption; and Mineral absorption. Therefore, we believe that our findings support the conclusion that ceftriaxone sodium exposure in pregnancy has a long-lasting adverse effect on the growth of offspring because of an imbalance of gut microbiota, especially S24–7, via different metabolic pathways.

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“…All these enter into the TCA cycle and gluconeogenesis to produce energy (Pilviet al, 2008). Moreover, valine is one of the branched-chain amino acids (BCAA), and its increasing evidenced that BCAAs play important roles in regulating the lipid metabolism (Ying et al, 2012;Nishimura et al, 2010;Xiao et al, 2016). In this study, the concentration of glycine, as a critical metabolite in the γ-glutamyl cycle, increased with the addition of SL.…”

Section: Discussionmentioning

confidence: 54%

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

Liu¹,

Niu²,

Tang³

et al. 2019

SA J. An. Sci.

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In this study, the effects of sea-buckthorn (Hippophae rhamnoides L.) leaves (SL) on the biochemical parameters and metabolomic profiling in Altay lamb (Ovis aries) were observed. Sixty six-month-old male Altay lambs (body weight 28.0 ± 3.5 kg) were randomly assigned to four groups (n=15). The experimental groups were named as CON, 2.5%, 5.0% and 7.5%. The group CON, contained animals fed with a basal diet. Animals of the other groups were fed a treatment diet consisting of 2.5% (Group 2.5%), 5.0% (Group 5.0%) and 7.5% (Group 7.5%) SL. The experimental period lasted 56 days. The results showed that the average daily gain (ADG) and average daily feed intake (ADFI) increased with the increase in the levels of dietary SL. Dietary SL showed a direct relationship with total protein (TP), albumin, globulin and total cholesterol (TC) content of the experimental animals. However, an indirect relationship was observed between dietary SL and the concentration of urea nitrogen (UN). The concentrations of glucose, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) showed quadratic change. Additional changes occurred in the endogenous metabolites involving multiple pathways. The pathways were tricarboxylic acid (TCA) cycle, the metabolism of protein and amino acid and the metabolism of fatty acid and steroid. The changes in metabolites primarily revealed an increase in amino acids and carbohydrates and a decrease in lipid metabolites. These findings provide a comprehensive insight into the effects of the metabolic aspects of sea-buckthorn leaves on Altay lambs. In addition, the present research results provide a better understanding to the development and utilization of sea-buckthorn as a healthy additive for small ruminant production.

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Effects of essential amino acids on lipid metabolism in mice and humans

Cited by 29 publications

References 30 publications

Metabolomic Profiles of Shift Workers and Day Workers: A Cross‐Sectional Study

Metabolomic Profiles of Shift Workers and Day Workers: A Cross‐Sectional Study

Effects of S24–7 on the weight of progeny rats after exposure to ceftriaxone sodium during pregnancy

Effects of sea-buckthorn leaves on performance and serum metabolic profiles in Altay lambs

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