Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy

Hwang, Chueh‐Lung; Yu, Chong‐Jen; Shih, Jin-Yuan; Yang, Pan‐Chyr; Wu, Ying-Tai

doi:10.1007/s00520-012-1452-5

Cited by 132 publications

(192 citation statements)

References 41 publications

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“…These studies, however, have enrolled small populations (n range from 24 to 46) and have dropout rates of 20.7% to 56% and present data on few patients (n = 11 -31). All the studies [5][6][7][8] found improvements in physical and functional capacity but failed to show improvements in overall HRQoL, anxiety, or depression. These results represent 164 patients with advanced-stage lung cancer, but only data on 118 patients were evaluated.…”

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confidence: 99%

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy

et al. 2015

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Introduction. Patients with advanced-stage lung cancer face poor survival and experience co-occurring chronic physical and psychosocial symptoms. Despite several years of research in exercise oncology, few exercise studies have targeted advanced lung cancer patients undergoing chemotherapy. The aim of the present study was to investigate the benefits of a 6-week supervised group exercise intervention and to outline the effect on aerobic capacity, strength, health-related quality of life (HRQoL), anxiety, and depression. Methods. VO2peak was assessed using an incremental exercise test. Muscle strength was measured with one repetition maximum test (1RM). HRQoL, anxiety, and depression were assessed using Functional Assessment of Cancer Therapy–Lung (FACT-L) scale and the Hospital Anxiety and Depression Scale (HADS). Results. One hundred and forthteen patients with advanced stage lung cancer were recruited. Forty-three patients dropped out. No serious adverse events were reported. Exercise adherence in the group training was 68%. Improvements in VO2peak ( P < .001) and 6-minute walk distance ( P < .001) and muscle strength measurements ( P < .05) were seen. There was a reduction in anxiety level ( P = .0007) and improvement in the emotional well-being parameter (FACT-L) but no statistically significant changes in HRQoL were observed. Conclusion. The results of the present study show that during a 6-week hospital-based supervised, structured, and group-based exercise program, patients with advanced-stage lung cancer (NSCLC IIIb-IV, ED-SCLC) improve their physical capacity (VO2peak, 1RM), functional capacity, anxiety level, and emotional well-being, but not their overall HRQoL. A randomized controlled trial testing the intervention including 216 patients is currently being carried out.

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confidence: 99%

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy

et al. 2015

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“…Positive effects have also been reported by prospective studies [52][53][54]. A recent randomized study demonstrated the efficacy of aerobic exercise in improving exercise capacity in a group of patients with adenocarcinoma and receiving targeted chemotherapy [55]. And finally, another recent study, albeit limited by the dimension of the small series, observed that an intensive rehabilitation protocol is capable of cancelling the toxic effects on lung functioning and QoL induced by radio/chemotherapy [56].…”

Section: Rehabilitation On Patients Undergoing Chemo And/or Radiothermentioning

confidence: 83%

Pulmonary Rehabilitation in lung cancer

Pasqua

Geraneo

Nardi

et al. 2015

Monaldi Arch Chest Dis

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Non-small-cell lung cancer (NSCLC) represents a very severe disease, being its incidence increasingly reported and, nowadays, successfully treatable only when surgery is deemed to be feasible. Furthermore, the disease and the clinical effects related to the complementary therapies (radio and/or chemotherapy) may strongly affect, frequently with dramatic clinical side effects, the patient’s ability to endure physical exercise. In such context, the PR(PR), which has already been proved to be useful and effective in other diseases such as COPD, could play a pivotal role. The aim of this review article is, therefore, to analyze the pertinent data recently reported in English literature in order to highlight the role of rehabilitation as complementary therapy in the management of patients with NSCLC. The evidence currently available suggests that, when surgery is indicated, PR is a safe and feasible option, both during pre-operative and post-operative timing.The safety and feasibility of rehabilitation are proven even in inoperable patients, although to date, little evidence has been reported on its role in the overall management of such complex diseases.

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“…Indeed, patients with chronic respiratory disease other than COPD also suffer from daily symptoms, muscle weakness, exercise intolerance, impaired mood status, poor quality of life and physical inactivity, despite optimal medical treatment [100][101][102][103][104][105][106]. Most of the new studies confirm the positive effects of exercise-based pulmonary rehabilitation in patients with nonsmall cell lung cancer (pre-/post-lung resection) [107][108][109][110][111][112][113][114][115][116][117], chronic respiratory failure due to kyphoscoliosis [118], pre-/post-lung transplantation [119][120][121][122], cystic fibrosis [123], bronchiectasis [124], severe respiratory failure receiving extracorporeal membrane oxygenation [125,126], interstitial lung disease [6,[127][128][129], and pulmonary arterial hypertension [130][131][132]. Existing COPD pulmonary rehabilitation programmes can be adapted to the particular needs of patients with chronic respiratory disease other than COPD, in particular the non-exercising parts [30].…”

Section: Pulmonary Rehabilitation In Chronic Respiratory Disease Othementioning

confidence: 99%

Pulmonary rehabilitation

Spruit

2014

Eur Respir Rev

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Pulmonary rehabilitation is a comprehensive intervention designed to improve the physical and psychological condition of people with chronic respiratory disease and promote the long-term adherence to health-enhancing behaviours. During the 2013 European Respiratory Society Annual Congress in Barcelona, Spain, a Clinical Year in Review session was held focusing on the latest developments in pulmonary rehabilitation. This review summarises some of the main findings of peer-reviewed articles focusing on pulmonary rehabilitation that were published in the 12 months prior to the 2013 Annual Congress. @ERSpublications Pulmonary rehabilitation is an important part of the integrated care of patients with chronic respiratory diseases

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Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy

Cited by 132 publications

References 41 publications

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy

The Impact of a Multidimensional Exercise Intervention on Physical and Functional Capacity, Anxiety, and Depression in Patients With Advanced-Stage Lung Cancer Undergoing Chemotherapy

Pulmonary Rehabilitation in lung cancer

Pulmonary rehabilitation

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