mong the known viral diseases, coronavirus disease 2019 has a global epidemic that has increased global mortality. In this disease, a strong innate response, indicated by an increase in CD14 + CD16 + activated monocytes and cytokine responses, is visible approximately 2 days after the onset of symptoms. Immunoglobulin M appears from the fourth day of infection and peaks approximately on the twentieth day and then decreases, while immunoglobulin G appears on the seventh day and reaches its peak on the twenty-fifth day and is maintained at a high level for 4 weeks. The elderly, especially the elderly with chronic diseases, are more prone to affliction and death from this disease. Of course, one of the reasons can be negative structural and functional changes in different