Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization

Lazzarini, Raffaella; Zabaleta, María Eléxpuru; Piva, Francesco; Giulietti, Matteo; Fulgenzi, Gianluca; Tartaglione, Maria Fiorella; Zingaretti, Laura M.; Tagliabracci, Adriano; Valentino, Matteo; Santarelli, Lory; Bracci, Massimo

doi:10.1016/j.ecoenv.2023.114650

Cited by 5 publications

(3 citation statements)

References 74 publications

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“…Penggunaan medan elektromagnetik dapat menjadi komponen terapi kesehatan dari berbagai situasi, seperti pemanfaatan dalam bidang pengobatan tulang. Paparan medan magnet frekuensi sangat rendah (ELF) dapat mempengaruhi kesehatan tulang dimana beberapa penelitian menunjukkan bahwa paparan ELF-MF dapat mempengaruhi pertumbuhan tulang, kepadatan tulang, dan metabolisme tulang (Lazzarini et al, 2023). Exteremely low frequency (ELF) memiliki hubungan positif dengan kandungan mineral tulang (BMC) dan kepadatan mineral tulang (BMD).…”

Section: Pendahuluanunclassified

Potensi Pemanfaatan Radiasi Medan Elektromagnetik Extremely Low Frequency untuk Terapi Kesehatan Tulang

Sinuraya,

Siahaan,

Sudarti

2023

Jur. Penel. Inov.

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Penelitian ini dilakukan untuk mengetahui potensi pemanfaatan radiasi medan elektromagnetik extremely low frequency (ELF) untuk terapi kesehatan tulang. Jenis penelitian yang digunakan adalah penelitian deskriptif kualitatif. Metode yang digunakan didalam penelitian ini adalah dengan melakukan kajian literatur dari berbagai jurnal nasional dan internasional yang relevan seperti Googlescholar, ScienceDirect, SpringerOpen, dan PubMed. Hasil penelitian menunjukkan bahwa extremely low frequency (ELF) sangat berperan penting dalam pertumbuhan dan penyembuhan tulang. Terapi tulang menggunakan ELF dapat merangsang fungsi osteoblas, yang merupakan sel-sel yang bertanggung jawab untuk pembentukan tulang baru. Berdasarkan analisa yang telah dilakukan dari berbagai jurnal relevan, baik nasional maupun internasional, disimpulkan bahwa bahwa pemanfaatan ELF dalam terapi kesehatan tulang memiliki potensi yang signifikan dan layak untuk dijelajahi lebih lanjut sebagai solusi terapi yang efektif dan inovatif untuk masalah kesehatan tulang di masa depan.

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Section: Pendahuluanunclassified

Potensi Pemanfaatan Radiasi Medan Elektromagnetik Extremely Low Frequency untuk Terapi Kesehatan Tulang

Sinuraya,

Siahaan,

Sudarti

2023

Jur. Penel. Inov.

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“…In recent years, several in vitro studies exposing various cell lines to extremely lowfrequency electromagnetic fields (ELF-EMF) (3 Hz-3kHz) are being published in order to understand the mechanisms of interaction between biological systems and this type of nonionising radiation (Cios et al, 2021;Mansoury et al, 2021;Maleki et al, 2022;Mansoury OPEN ACCESS EDITED BY et al, 2022;Nieminen et al, 2022;Sołek et al, 2022;Elexpuru-Zabaleta et al, 2023;Lazzarini et al, 2023). Magnetic field exposure systems are designed to expose cell samples or devices to controlled magnetic fields and are widely used in scientific and industrial applications (Kirschvink, 1992).…”

Section: Introductionmentioning

confidence: 99%

“…Magnetic field exposure systems are designed to expose cell samples or devices to controlled magnetic fields and are widely used in scientific and industrial applications (Kirschvink, 1992). These systems can typically contain different coil geometries that act as passive elements for magnetic field generation such as solenoids (Han et al, 2018;Sanie-Jahromi and Saadat, 2018;Costantini et al, 2019;Samiei et al, 2020;Mansoury et al, 2021;Salek et al, 2021;Maleki et al, 2022;Mansoury et al, 2022), circular (Yuan et al, 2018;López et al, 2019;García-minguillán et al, 2020;Xu et al, 2020;Yuan et al, 2020;Asadian et al, 2021) or square (Consales et al, 2018;Sun et al, 2018;Zuo et al, 2020;Elexpuru-Zabaleta et al, 2023;Lazzarini et al, 2023) coils arranged in different configurations, such as the Merrit configuration (Kirschvink, 1992) or the Helmholtz configuration (Kirschvink, 1992;López et al, 2019;García-minguillán et al, 2020;Xu et al, 2020;Asadian et al, 2021;Cios et al, 2021;Lim et al, 2021). The latter is one of the most popular configurations for exposing cell cultures or small animals to ELF-EMF (López et al, 2019;Garcíaminguillán et al, 2020;Xu et al, 2020;Asadian et al, 2021;Cios et al, 2021;Lim et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Design and characterisation of a cell exposure system with high magnetic field homogeneity: RILZ coils

Rivera González,

López de Mingo,

Amuneke Ramírez

et al. 2024

Front. Bioeng. Biotechnol.

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In vitro studies requiring controlled exposure to low-frequency electromagnetic fields employ exposure systems with different geometries and configurations, the Helmholtz configuration being one of the most widely used. This configuration has limitations in the homogeneity of the spatial distribution of the magnetic field intensity values. We present the design, manufacturing, and characterisation of a new coil system, called RILZ configuration, which improves the distribution of magnetic field intensity values in the three dimensions of space for three different heights in comparison with the traditional circular coils in Helmholtz configuration. In addition, a comparative study of the cellular response in CT2A cultures exposed to a magnetic field of 50 Hz and 100 µT for 48 hrs is performed with both exposure systems. The results of the study show reduced values of deviation from the central value of magnetic field intensity using the RILZ coil system. These differences are statistically significant compared to the Helmholtz configuration for the three Cartesian directions: x (p < 0.01), y (p < 0.01), z (p < 0.01). In addition, the intensity values for three different heights are statistically significantly correlated using the RILZ coil system (p < 0.01). The differences in cell behaviour are also statistically significant between the two systems (p < 0.01) and may be directly related to the differences found in the distribution of intensity values between the two systems. This study highlights the importance of the homogeneity of the magnetic field intensity generated by the exposure systems used and offers an effective solution to control the magnetic field exposure parameters in vitro assays.

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The Application of Electromagnetic Fields in Cancer

Aydemir,

Arslan,

Görkay

2023

Advances in Experimental Medicine and Biology

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Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization

Cited by 5 publications

References 74 publications

Potensi Pemanfaatan Radiasi Medan Elektromagnetik Extremely Low Frequency untuk Terapi Kesehatan Tulang

Potensi Pemanfaatan Radiasi Medan Elektromagnetik Extremely Low Frequency untuk Terapi Kesehatan Tulang

Design and characterisation of a cell exposure system with high magnetic field homogeneity: RILZ coils

The Application of Electromagnetic Fields in Cancer

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