Effects of Functional Extracts Made from Fermented Plants on Serum Glucose and Lipids Level in Streptozotocin-Induced Diabetic Rats

Lee, Soo-Jung; Sung, D.H.; Shin, Jung-Hye; Sung, Nak‐Ju

doi:10.3746/jfn.2010.15.3.167

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…The germinated rough rice extract group tended to show a lower CPK value than the diabetic group, and in particular, 3% GIRRE and 3% GGRRE displayed a CPK level similar to that of the normal group. Previous research suggests that the increase of CPK can cause central nervous system diseases (22). The above results show that 3% GGRRE and 3% GIRRE, rather than the 1% germinated rough rice extracts, were considerably more helpful in reducing blood glucose levels and improving glucose tolerance.…”

Section: Biochemical Parametersmentioning

confidence: 50%

“…Serum ALT and AST activities in diabetes were significantly higher in the DC group than the NC group (Table 4). STZ leads to liver damage by causing light degeneration of lipids in the liver, and ALT and AST activities are used as an index for liver damage (22). The ALT and AST activity in the 3% GGRRE group was significantly decreased in comparison with the DC group, which indicates germinated rough rice extract intake can prevent liver damage from diabetes.…”

Section: Biochemical Parametersmentioning

confidence: 95%

“…AST and ALT are the enzymes that synthesize amino acids in the body. They exist in various kinds of organic cells, but most of them are in the liver (22). Serum ALT and AST activities in diabetes were significantly higher in the DC group than the NC group (Table 4).…”

Section: Biochemical Parametersmentioning

confidence: 96%

“…Every diabetic group showed a significantly higher weight of their liver and kidney than the normal group did, which conforms to the results of other reports that state STZ-induced diabetic rats have fatter livers and kidneys than normal ones. It is assumed that the hypertrophic phenomenon of the liver results from decreased insulin secretion and abnormal glucose metabolism, such that lipids accumulate in the liver (19)(20)(21)(22)(23). Although there was not a significant difference, the 3% germinated rough rice extract group displayed a lower liver weight than the 1% germinated rough rice extract group.…”

Section: Body Weight Gain Food Intake Germinated Rough Rice Extractmentioning

confidence: 99%

“…Although BUN mostly increases as a result of diabetes, the 3% GIRRE and 3% GGRRE groups showed a significant decrease in BUN levels than the control diabetic group. Creatinine results from proteins being broken down in the body (22). The blood creatinine level is important to determine kidney function, and its increase means that the kidney is not functioning properly.…”

Section: Biochemical Parametersmentioning

confidence: 99%

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Hypoglycemic Effects of Germinated Rough Rice Extract in Streptozotocin-induced Diabetic Rats

Lee¹,

Hwang²,

Woo³

et al. 2011

JFN

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The hypoglycemic effects of germinated rough rice extract in streptozotocin (STZ)-induced diabetic rats were investigated. Weight gain was significantly lower in the diabetic groups than in the normal control (NC); however, they were higher in the 1% and 3% diabetic groups given germinated Goami2 rough rice extract (DM-3%GGRRE) than in the diabetic control (DC). While food intake in all diabetic groups was significantly higher than that of the NC, there was no significant difference among all diabetic groups. The weight percentages of liver and kidney in all diabetic groups were significantly higher than that of the NC. In terms of blood glucose, the diabetic group showed about a three times larger value than the normal group. Moreover, in the 3% germinated rough rice extract group, the blood glucose level became lowered. The levels of alanine transaminase, aspartate transaminase, blood urea nitrogen, creatinine phosphokinsae, and creatinine increased in general with the induction of diabetes using STZ; however, the 3% GGRRE-treated group displayed a significant decrease in these levels compared to the diabetic group. The results show that the 3% GGRRE, rather than the 1% GGRRE, was considerably more effective at reducing blood glucose and improving impaired glucose tolerance, suggesting the germinated rice extracts may play a role in preventing liver and kidney damage.

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Section: Biochemical Parametersmentioning

confidence: 50%

Section: Biochemical Parametersmentioning

confidence: 95%

Section: Biochemical Parametersmentioning

confidence: 96%

Section: Body Weight Gain Food Intake Germinated Rough Rice Extractmentioning

confidence: 99%

Section: Biochemical Parametersmentioning

confidence: 99%

See 3 more Smart Citations

Hypoglycemic Effects of Germinated Rough Rice Extract in Streptozotocin-induced Diabetic Rats

Lee¹,

Hwang²,

Woo³

et al. 2011

JFN

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Hypoglycemic and Hypolipidemic Effects of Orostachys japonicus with Medicinal Herbs in Streptozotocin-Induced Diabetic Rats

이수정¹,

신정혜²,

주종찬

et al. 2013

Journal of the Korean Society of Food Science and Nutrition

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The hypoglycemic and hypolipidemic effects from Wa-song (Orostachys japonicus) extracts with mixtures of medicinal herbs (such as Baekbokyung, Changchul and Sa-in) were evaluated in the streptozotocin (STZ)-induced diabetic rats. Thirty-five Sprague-Dawley rats were assigned to five groups; normal, diabetic control (D-control), a group fed a medicinal herbs mixture (D-MH), and a group fed composites of O. japonicus with mixtures of medicinal herbs (1:1, D-MHOA and 3:1, D-MHOB). All were fed on their diet for 4 weeks. After 4 weeks, the body weight of all experimental groups increased compared to the diabetic control group, with the D-MHOB group having a significantly higher increase. Fasting glucose levels in all experimental groups (compared to the D-control group) significantly decreased after 2 weeks, but between 2∼3 weeks, the levels in the D-MH group were similar to the D-MHOA group. After 4 weeks, the fasting glucose level of the D-MHOB group was the lowest compared to the other groups. In a test of oral glucose tolerance, blood glucose levels were highest 60 minutes after feeding glucose; however this level improved significantly in the groups fed an experimental diet compared to the D-control group. Glycosylated hemoglobin levels were 1.9 times higher in the D-control group than the normal (3.9%), but levels in the experimental groups were significantly decreased in D-MHOA and D-MHOB groups compared to the D-MH group. In the high amounts of O. japonicus to medicinal herbs mixture, total lipids and cholesterol significantly decreased in the serum, while HDL-C levels increased. GPT activity was significantly lower in the D-MHOB group compared to the other groups. Lipid peroxide levels decreased in the D-MHOA and D-MHOB groups compared to the D-MH group. Antioxidant activity was higher depending on the dose of O. japonicus. Overall, O. japonicus exhibited effective hypoglycemic and hypolipidemic actions enhanced by a combination of medicinal herbs.

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Effect of Black Garlic and Gaeddongssuk (Artemisia annua L.) Extracts on the Lipid Profile and Hepatic Antioxidant Enzyme Activities of Exercised Rats

강재란¹,

이수정²,

황초롱

et al. 2013

Journal of the Korean Society of Food Science and Nutrition

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Effects of Functional Extracts Made from Fermented Plants on Serum Glucose and Lipids Level in Streptozotocin-Induced Diabetic Rats

Cited by 3 publications

References 34 publications

Hypoglycemic Effects of Germinated Rough Rice Extract in Streptozotocin-induced Diabetic Rats

Hypoglycemic Effects of Germinated Rough Rice Extract in Streptozotocin-induced Diabetic Rats

Hypoglycemic and Hypolipidemic Effects of Orostachys japonicus with Medicinal Herbs in Streptozotocin-Induced Diabetic Rats

Effect of Black Garlic and Gaeddongssuk (Artemisia annua L.) Extracts on the Lipid Profile and Hepatic Antioxidant Enzyme Activities of Exercised Rats

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