Effects of functional groups on the fragmentation of dyes in electrospray and atmospheric pressure chemical ionization mass spectra

Holčapek, Michal; Volná, Kateřina; Vaněrková, Dana

doi:10.1016/j.dyepig.2006.05.040

Cited by 66 publications

(54 citation statements)

References 37 publications

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“…Various methods for the determination of dyes in foods have been reported, including capillary electrophoresis [6][7][8][9][10], thinlayer chromatography [11], ion-pair chromatography [12,13], high performance liquid chromatography (HPLC) with ultraviolet/visible (UV/Vis) or diode-array detector (DAD) detection [14][15][16][17][18][19][20][21][22][23][24][25] and liquid chromatography-mass spectrometry (LC-MS) [26][27][28][29][30][31][32]. HPLC coupled with UV/Vis or DAD detection is the most commonly used technique because dyes absorb strongly at the ultraviolet and/or visible wavelength.…”

Section: Introductionmentioning

confidence: 99%

“…Besides, false positives caused by complex food matrices are frequently encountered [6,18]. To solve these problems, the selective detection by liquid chromatography tandem mass spectrometry (LC-MS/MS) has been used [26][27][28][29][30][31][32] for it can provide detailed structural information. In the selective reaction monitoring (SRM) mode, the specific MS transition (precursor ion → product ion) can exclude the presence of interference substances, improving the accuracy of the quantification.…”

Section: Introductionmentioning

confidence: 99%

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Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography–electrospray tandem mass spectrometry

Feng

Yan

Yong

et al. 2011

Journal of Chromatography B

125

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a b s t r a c tA method combining solid phase extraction with high performance liquid chromatography-electrospray ionization tandem mass spectrometry was developed for the highly sensitive and accurate screening of 40 dyes, most of which are banned in foods. Electrospray ionization tandem mass spectrometry was used to identify and quantify a large number of dyes for the first time, and demonstrated greater accuracy and sensitivity than the conventional liquid chromatography-ultraviolet/visible methods. The limits of detection at a signal-to-noise ratio of 3 for the dyes are 0.0001-0.01 mg/L except for Tartrazine, Amaranth, New Red and Ponceau 4R, with detection limits of 0.5, 0.25, 0.125 and 0.125 mg/L, respectively. When this method was applied to screening of dyes in soft drinks, the recoveries ranged from 91.1 to 105%. This method has been successfully applied to screening of illegal dyes in commercial soft drink samples, and it is valuable to ensure the safety of food.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography–electrospray tandem mass spectrometry

Feng

Yan

Yong

et al. 2011

Journal of Chromatography B

125

View full text Add to dashboard Cite

show abstract

“…A similar phenomenonÀ thermally induced fragmentation in the atmospheric pressure chemical ionization (APCI) source, was observed for electrochemically modified lidocaine [16]. Full-scan fragmentation ions with various abundance, using soft ionization techniques like ESI, APCI or APPI (atmospheric pressure photoionization), are known, especially for APCI source [17]. Employing accurate mass measurement is highly useful, as it enables to determine the elemental formula of observed target compound, thus vastly limiting the number of possible solutions and giving valuable insight about the oxidation transformations that the compound has undergone.…”

Section: Resultsmentioning

confidence: 80%

High Performance Liquid Chromatography/Electrochemistry/High Resolution Electrospray Ionization‐Mass Spectrometry (HPLC/EC/HR ESI‐MS) Characterization of Selected Cytokinins Oxidation Products

et al. 2015

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Electrochemistry combined with mass spectrometry represents an emerging analytical technique used to study the oxidation pathway of various drugs and in vivo occurring compounds, continuously showing a capability to generate many known metabolites or new oxidation products. An on‐line HPLC/EC/HR ESI‐MS method had been used to investigate the oxidation of selected cytokinin compounds. This setup allowed rapid identification and general structure elucidation of the obtained products. An electrochemical oxidation of isopentenyladenine resulted in five products, including hydroxylated and dehydrogenated products, which correlates very well with its in vivo metabolism. Electrochemical conversion of trans‐zeatin revealed six products, with two dehydrogenation products corresponding to its in vivo occurring metabolites. cis‐Zeatin oxidation in the electrochemical cell gave rise to eight products, resembling similarity to trans‐zeatin oxidation. All three compounds underwent a complete turnover mainly through two oxidation reactions occurring in the electrochemical celldehydrogenation and a less typical aliphatic hydroxylation. The resulting products are in correlation with their known in vivo metabolism.

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“…2,10,11 Mass spectrometry (MS) detectors are becoming the most commonly used methods for detecting synthetic pigment residue. MS detectors are replacing the ultraviolet detectors (UV) because they provide more structural information and can conform to the specifications for confirmatory methods included in the European Commission Decision 2002/657/EC.…”

Section: Introductionmentioning

confidence: 99%

Rapid Method for Quantification of Seven Synthetic Pigments in Colored Chinese Steamed Buns Using UFLC-MS/MS without SPE

2015

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Effects of functional groups on the fragmentation of dyes in electrospray and atmospheric pressure chemical ionization mass spectra

Cited by 66 publications

References 37 publications

Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography–electrospray tandem mass spectrometry

Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography–electrospray tandem mass spectrometry

High Performance Liquid Chromatography/Electrochemistry/High Resolution Electrospray Ionization‐Mass Spectrometry (HPLC/EC/HR ESI‐MS) Characterization of Selected Cytokinins Oxidation Products

Rapid Method for Quantification of Seven Synthetic Pigments in Colored Chinese Steamed Buns Using UFLC-MS/MS without SPE

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