Effects of grape seed extract consumption on platelet function in postmenopausal women

Shenoy, Sonia F; Keen, Carl L.; Kalgaonkar, Swati; Polagruto, John A.

doi:10.1016/j.thromres.2007.09.004

Cited by 25 publications

(18 citation statements)

References 7 publications

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“…Also, in one double-blind study, the intake of 400 mg of flavanol-rich grape seed extract for 8 weeks yielded positive results for platelet function in postmenopausal women. Their data indicated a trend toward increased ADP-collagen-stimulated platelet closure time at week 8 (Shenoy et al, 2007).…”

Section: Clinical Studiesmentioning

confidence: 96%

Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Nassiri‐Asl

Hosseinzadeh²

2009

Phytotherapy Research

263

171

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Vitis vinifera, known as the grapevine, is native to southern Europe and Western Asia. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines, and the stilbene derivative resveratrol. Grape seed extract in particular has been reported to possess a broad spectrum of pharmacological and therapeutic effects such as antioxidative, anti-inflammatory, and antimicrobial activities, as well as having cardioprotective, hepatoprotective, and neuroprotective effects. Thus, the present review attempts to give a short overview on the pharmacological, toxicological, and clinical studies of grape and its active components.

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Section: Clinical Studiesmentioning

confidence: 96%

Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Nassiri‐Asl

Hosseinzadeh²

2009

Phytotherapy Research

263

171

View full text Add to dashboard Cite

show abstract

“…Grape seeds extract have been reported for antiinflammatory, antioxidant and antimicrobial activity. It has cardioprotective, hepatoprotective, and neuroprotective effects as well [97]. Studies have shown that grape seed contain a particular flavonoid called anthocyanin oligomers in considerable amounts.…”

Section: Herbal Remedy For Male Infertilitymentioning

confidence: 99%

Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress

et al. 2017

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Defective sperm function has been identified as the most common cause of infertility. The objective of this study was to review recent findings on the effects of various antioxidants on male fertility. High amounts of poly unsaturated fatty acid are found in the mammalian spermatozoa membranes, thereby making them susceptible to lipid peroxidation. Although, free radicals and reactive oxygen species (ROS) play major roles in reproduction, they are strongly associated with oxidative stress. Furthermore, factors such as obesity, inflammation, pollutants and cigarette smoking are negatively correlated with spermatogenesis. Endogenous antioxidants system exists to mediate these damages. In a normal physiological state, the seminal plasma contains antioxidant enzyme mechanism that is capable of quenching these ROS as well as protecting the spermatozoa against any likely damage. However, high level of ROS triggered by inflammatory cells and oxidation of fatty acid in obese subjects may down play antioxidant mechanism resulting in oxidative stress. Evaluation of such oxidative stress is the first step in the treatment of male infertility through administration of suitable antioxidant. Notably, antioxidant such as vitamin E and C, carotenoids and carnitine have been found beneficial in restoring a balance between ROS generation and scavenging activities. There are emerging evidences that herbal products can also boost male reproductive functions. Nonetheless, a good lifestyle, regular exercise, avoidance of stress and observing safety rules at work are habits that can reverse male infertility.

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“…Polyphenols are thought to contribute to the cardio‐protective effects of a diet rich in fruit and vegetables and a number of published studies have focused on their potential to modulate platelet activity. A number of human intervention trials with polyphenol‐rich foods and beverages such as onion soup, grape juice, pomegranate juice, cocoa and berry fruits, and extracts such as grape seed extract, have reported improved vascular function and reduced platelet aggregation post ingestion. The evidence of anti‐aggregatory effects of polyphenol‐rich foods is strongest for cocoa .…”

Section: Introductionmentioning

confidence: 99%

Lack of effect of bioactive‐rich extracts of pomegranate, persimmon, nettle, dill, kale andSideritisand isolated bioactives on platelet function

et al. 2013

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Effects of grape seed extract consumption on platelet function in postmenopausal women

Cited by 25 publications

References 7 publications

Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds

Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress

Lack of effect of bioactive‐rich extracts of pomegranate, persimmon, nettle, dill, kale andSideritisand isolated bioactives on platelet function

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