Effects of growth hormone and functional appliance on mandibular growth in an adolescent rat model

Wang, Shuai; Lu, Yao; Li, Mei; Zhan, Huichun; Rui, Yong; Liu, Yu; Zhao, Zhihe

doi:10.2319/120417-829.1

Cited by 18 publications

(20 citation statements)

References 24 publications

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“…The use of a growth hormone in growing rats in combination with functional appliances results in condylar growth. The same results, but significantly less growth, were reported with the application of functional appliances without administering a growth hormone according to Wang et al [ 21 ]. There is also a correlation between the amount of mandibular advancement and the growth of the condyle.…”

Section: Resultssupporting

confidence: 74%

“…Six studies used randomization methods when allocating animals into experimental and control groups [ 8 , 16 , 17 , 21 , 22 , 23 ], although they did not specify the method used. None noted any blinding of the experimental procedure, as this was not feasible with live animals wearing appliances.…”

Section: Resultsmentioning

confidence: 99%

“…However, most appliances were used prior to the growth spurt, where estrogen levels are not significantly different between males and females [ 20 ]. The results of Class II functional appliance treatment also depend upon the capacity of the bite-jumping appliance [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Anterior Mandibular Displacement in Growing Rats—A Systematic Review

Ferdianakis

Lyros

Tsolakis

et al. 2022

Animals

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Skeletal Class II malocclusion is the most common skeletal anomaly in orthodontics. Growth in the body of the deficient mandible is induced by periosteal apposition and endochondral ossification in the condyle. Functional appliances have been used in the correction of Class II malocclusions by inducing mandibular growth. Despite their utilization though, their effect still remains controversial. The aim of the present study is to review the existing literature regarding the effects of mandibular protrusion in mandibular growth of growing rats. A protocol was followed according to the guidelines of the Cohrane Handbook for Systematic Reviews. Databases were searched using a specific algorithm. From the ten studies finally analyzed, we conclude that the use of a functional appliance in growing rats induces cell proliferation and bone formation in their condyles, resulting in mandibular growth.

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Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

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Anterior Mandibular Displacement in Growing Rats—A Systematic Review

Ferdianakis

Lyros

Tsolakis

et al. 2022

Animals

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“…through the digestive system. Moreover, as the KYNA was administrated in drinking water, all rats received the same feed and the potential impact of feed texture on mandible morphology and growth was reduced to minimum [46]. It is well known that KYNA given intra-gastrically is absorbed from the gut, distributed to internal organs and tissues, and finally excreted in the urine [35], without permanently elevating serum KYNA levels.…”

Section: Discussionmentioning

confidence: 99%

Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats

et al. 2019

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Kynurenic acid (KYNA) is a neuroactive metabolite of tryptophan. KYNA naturally occurs in breast milk and its content increases with lactation, indicating the role of neonatal nutrition in general growth with long-term health effects. KYNA is also an antagonist of ionotropic glutamate receptors expressed in bone cells. The aim of this study was to establish the effects of chronic KYNA supplementation on bone homeostasis in young rats, using mandible as a model bone. Female and male newborn Wistar rats were divided into control and KYNA-administered groups until 60 days of age (25x101 mg/L or 25x102 mg/L in drinking water). Hemimandibles were subjected to densitometry, computed tomography analysis and mechanical testing. Rats supplemented with KYNA at both doses showed a decrease in body weight. There were no effects of KYNA administration and mandible histomorphometry. In males, a significant quadratic effect (P < 0.001) was observed in the densitometry of the hemimandible, where BMD increased in the group supplemented with 2.5x101 mg/L of KYNA. Analysis of mechanical tests data showed that when fracture forces were corrected for bone geometry and rats body weight the improvement of bone material properties was observed in male and female rats supplemented with lower dose of KYNA. This study showed that chronic supplementation with KYNA may limit weight gain in the young, without adversely affecting the development of the skeleton.

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“…According to Davidopoulou and Chatzigianni (2017) after the administration of growth hormone, facial convexity decreased, while the mandibular length and posterior facial height were both increased in children with a reduced somatic growth due to a different etiology (Choi et al, 2017). In addition, Wang et al (2018) reported that functional appliance treatment in combination with growth hormone administration stimulated mandibular growth in adolescent rats. Given these findings, there is a possibility that the growth hormone treatment or the combination of growth hormone treatment and functional therapy might have enhanced the mandibular growth in this case.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Orthodontic Treatment of a Patient With Prader–Willi Syndrome

Uemura

Oka

Kurosaka

et al. 2020

The Cleft Palate Craniofacial Journal

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Prader–Willi syndrome (PWS) is a rare genetic disorder caused by a defect in paternally expressed genes in the 15q11-q13 region. Prader–Willi syndrome affects many parts of the body and involves craniofacial and dentofacial abnormalities. We herein report the successful 2-stage orthodontic treatment of an 8-year-old girl with PWS caused by paternal 15q11-q13 deletion. She presented with a skeletal class II relationship with mandibular deviation, a deep overbite, and severe crowding of the lower dental arch. Functional appliance therapy was utilized to improve her skeletal discrepancy. The second phase of orthodontic treatment using fixed appliances was started at 14.5 years old, which improved her remained crowding and large overbite. As a result, her facial appearance and occlusion were improved without any discernible relapse after 2 years of retention. We describe the outcomes of orthodontic treatment for a patient with PWS and discuss the specific attention during orthodontic treatment.

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Effects of growth hormone and functional appliance on mandibular growth in an adolescent rat model

Abstract: The FA as well as GH+FA stimulated mandibular growth in adolescent rats.

Cited by 18 publications

References 24 publications

Anterior Mandibular Displacement in Growing Rats—A Systematic Review

Anterior Mandibular Displacement in Growing Rats—A Systematic Review

Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats

Comprehensive Orthodontic Treatment of a Patient With Prader–Willi Syndrome

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