Effects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography (PET)

Vollenweider, Franz X.; Maguire, R. Paul; Leenders, Klaus L.; Mathys, K.; Angst, J.

doi:10.1016/s0925-4927(98)00033-x

Cited by 69 publications

(52 citation statements)

References 45 publications

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“…The cingulate and ventral striatum activations that correlated with these subjective experiences (see Figure 3) are in agreement with the PET study by Vollenweider et al (1998), where it was shown that d-amphetamine produced a mania-like syndrome concomitantly with a widespread increase in absolute cerebral metabolism, which was significant in the anterior cingulate cortex, caudate nucleus, putamen, and thalamus. Dopamine release in the ventral striatum is linked to the rewarding and locomotor-stimulant effects of abused drugs such as amphetamine in experimental animals (Parkinson et al, 1999).…”

Section: Discussionsupporting

confidence: 89%

“…The present study reports p-values based on a group analysis for a priori regions of interest given the strong hypotheses generated by previous independent studies (Breiter and Rosen, 1999;Vollenweider et al, 1998;Goldstein and Volkow, 2002;Martinez et al, 2003;Volkow et al, 2001Volkow et al, , 2002. The p-values were corrected for the number of comparisons made within each region using the small volume correction (SVC) procedure (Worsley et al, 1996) consisting of defining a 10 mm sphere centered at the peak voxel of activation clusters.…”

Section: Discussionmentioning

confidence: 99%

“…The p-values were corrected for the number of comparisons made within each region using the small volume correction (SVC) procedure (Worsley et al, 1996) consisting of defining a 10 mm sphere centered at the peak voxel of activation clusters. A priori regions of interest included the medial orbitofrontal cortex Volkow et al, 2001), the anterior cingulate cortex (Vollenweider et al, 1998;Volkow et al, 2002), and the (ventral) striatum (Breiter and Rosen, 1999;Martinez et al, 2003). Finally, checks were performed using the estimated motion as a covariate of no interest to rule out the possibility of the observed results being due to motionrelated artifacts.…”

Section: Discussionmentioning

confidence: 99%

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Methamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects

Völlm

Araújo

Cowen

et al. 2004

Neuropsychopharmacol

145

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Amphetamines are highly addictive drugs that have pronounced effects on emotional and cognitive behavior in humans. These effects are mediated through their potent dopaminergic agonistic properties. Dopamine has also been implicated in the modulation of responses of the 'reward circuit' in animal and human studies. In this study we use functional magnetic resonance imaging (fMRI) to identify the brain circuitry involved in the psychostimulant effect of methamphetamine in psychostimulant-naïve human subjects. Seven healthy volunteers were scanned in a 3T MR imaging system. They received single-blind intravenous infusions of methamphetamine (0.15 mg/kg), and rated their experience of 'mind-racing' on a button press throughout the experiment. Data were analyzed with statistical parametric mapping methods. Amphetamine administration activated the medial orbitofrontal cortex, the rostral part of the anterior cingulate cortex, and the ventral striatum. Ratings of 'mind-racing' after methamphetamine infusion correlated with activations in the rostral part of the anterior cingulate cortex and in the ventral striatum. In addition, activations in the medial orbitofrontal cortex were independent of motor and related responses involved in making the ratings. These findings indicate that the first administration of a psychostimulant to human subjects activates classical reward circuitry. Our data also support recent hypotheses suggesting a central role for the orbitofrontal cortex in drug reinforcement and the development of addiction.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Methamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects

Völlm

Araújo

Cowen

et al. 2004

Neuropsychopharmacol

145

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“…One way to use fMRI to measure the effects of amphetamine on the baseline levels of neural activity, independent of task, might be to administer the drug intravenously. Indeed, it has been reported that intravenous infusions of cocaine, another psychostimulant, induced regionally specific fMRI activation (Breiter et al 1997) that was consistent with known neuroanatomical pathways and anatomical measurements of stimulant effects (Vollenweider et al 1998).…”

Section: Discussionmentioning

confidence: 69%

An fMRI Study of the Effect of Amphetamine on Brain Activity,

Uftring

Wachtel

Chu

et al. 2001

Neuropsychopharmacology

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“…Compared to [O-15]water PET for the measurement of cerebral blood flow with a temporal resolution of 10-30 s (Silbersweig et al, 1993), 18-FDG shows a relatively slower temporal resolution of approximately 20 min, which would indicate that 18-FDG is more appropriate for the investigation of 'tonic' stimulation paradigms or pharmacological challenges (Volkow et al, 1990(Volkow et al, , 1999Vollenweider et al, 1998;Gouzoulis-Mayfrank et al, 1999;Schreckenberger et al, 1999). Since the psychophysiological changes under acute alcohol influence are rather tonic, they are not expected to be adequately Table 3b.…”

Section: Methodical Considerationsmentioning

confidence: 99%

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

Schreckenberger

Amberg

Scheurich

et al. 2004

Neuropsychopharmacol

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The acute influence of ethanol on cerebral activity induces complex psycho-physiological effects that are considerably more pronounced during acute ethanol influx than during maximal blood alcohol concentration (elimination phase). Despite the psychiatric and forensic relevance of these different ethanol effects, the underlying neuronal mechanisms are still unclear. In total, 20 male healthy volunteers were investigated each with three different experimental conditions in a randomized order using an intravenous ethanol challenge (40 g bolus infusion): during influx phase, elimination phase, and under placebo condition. During and after the ethanol (or placebo) infusion, neuropsychological testing of divided attention for visual and auditory stimuli was performed with subsequent 18-FDG PET acquisition. The PET data were analysed using SPM99. Ethanol influx and elimination phase showed focal activations in the bilateral striatum and frontal cortex and deactivations in the occipital cortex. The comparison of influx phase vs elimination phase revealed activations in the anterior cingulate and right prefrontal cortex, relevant deactivations were found in the left superior temporal cortex including Wernicke's area. Neuropsychological testing showed an attentional impairment under ethanol influx compared to ethanol elimination and placebo with an inverse correlation of the attentional performance for auditory stimuli to occipital activity and for visual stimuli to the left temporal (including auditory) cortex. Acute ethanol administration in healthy volunteers stimulates those striatal regions that are considered to have a particular relevance for alcohol craving ('reward system'). Modality specific reciprocal inhibition of sensory cortex activity seems to be relevant for attentional performance during acute alcohol impact.

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Effects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography (PET)

Cited by 69 publications

References 45 publications

Methamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects

Methamphetamine Activates Reward Circuitry in Drug Naïve Human Subjects

An fMRI Study of the Effect of Amphetamine on Brain Activity,

Acute Alcohol Effects on Neuronal and Attentional Processing: Striatal Reward System and Inhibitory Sensory Interactions under Acute Ethanol Challenge

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