Effects of Human Placental Extract on Brain Monoamines and Monoamine Oxidase Activity in Rats.

Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-κB and AP-1 in PMA-differentiated THP-1 cells

“…In fact, human placenta extract (HPE) has been used as a traditional therapeutic agent in many Asian countries for the treatment of diseases or the replenishment of vital essence [1,4]. Therapeutic effects of HPE on arthritic diseases and inflammatory skin diseases such as psoriasis have also been reported [4,5]. In addition, HPE has been shown to possess antioxidative activities [6] which counteract the adverse consequences of oxidative stress, which interferes with normal metabolism and physiological balance by damaging biological molecules including proteins, lipids and DNA [7].…”

JBP485 promotes tear and mucin secretion in ocular surface epithelia

“…JBP485 was first found as a defined hydrolysate from human placenta. Extensive and accumulating investigations demonstrate that human placenta has multiple biological functions, including anti-inflammatory effects, anti-platelet aggregation, protection and regeneration of hepatocytes, regulation of hormonal balance, modulation of immune reaction, and promotion of wound healing 30 31 32 33 34 . JBP485 has also consistently shown the same kinds of biological effects.…”

Human placental extract reduces allergic inflammation in a murine allergic rhinitis model

“…Numerous studies have demonstrated the biological actions of HPE in various diseases . Previous studies reported the role of HPE for maternal–fetal tolerance.…”

“…Numerous studies have demonstrated the biological actions of HPE in various diseases. 1,6,12 Previous studies reported the role of HPE for maternal-fetal tolerance. They suggested that the inhibitory effect of syncytiotrophoblast extract on the proliferative responses of lymphocytes to stimulants may be due to a cytostatic effect, representing a possible contributing factor in fetalmaternal tolerance.…”