Effects of Hyperbaric Exposure with High Oxygen Concentration on the Physical Activity of Developing Rats

Matsumoto, Akiko; Okiura, Tomonori; Morimatsu, Fumiki; Ohira, Yoshinobu; Ishihara, Akihiko

doi:10.1159/000097319

Cited by 29 publications

(34 citation statements)

References 67 publications

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“…The increase in the pressure and concentration of oxygen by hyperbaric exposure with high oxygen concentration results in more oxygen being dissolved in the blood and plasma, making the oxygen available for diffusion into the tissues and offering an increased oxidative capacity in skeletal muscles [9,16]. An interesting finding in our previous studies [8,17] was that the growth-related increase in the glucose level of diabetic rats was completely inhibited by hyperbaric exposure with high oxygen concentration.…”

Section: Discussionmentioning

confidence: 91%

Hyperbaric Exposure with High Oxygen Concentration Improves Altered Fiber Types in the Plantaris Muscle of Diabetic Goto-Kakizaki Rats

et al. 2007

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Hyperbaric exposure with high oxygen concentration inhibits a growth-related increase in the glucose and insulin of diabetic rats. In this study, 5-week-old diabetic Goto-Kakizaki rats were exposed to a hyperbaric environment (1.25 atmospheric pressure) with a high oxygen concentration (36%) for 6 h daily. Fiber type distributions and oxidative enzyme activities in the fast-twitch plantaris muscle of Goto-Kakizaki rats were examined after hyperbaric exposure for 4 weeks. The percentages of high-oxidative type I and type IIA fibers increased and that of low-oxidative type IIB fibers decreased after hyperbaric exposure. Furthermore, the fiber oxidative enzyme activity increased after hyperbaric exposure, regardless of fiber type. It is concluded that altered patterns of fiber types in the plantaris muscle of diabetic rats shift toward normal, which is observed in nondiabetic rats, following hyperbaric exposure with high oxygen concentration.Key words: diabetes mellitus, hyperbaric oxygenation, plantaris muscle.Patients and animal models with type 2 diabetes mellitus exhibit altered patterns of fiber types in skeletal muscles [1][2][3][4][5]. Goto-Kakizaki rats, animal models of spontaneous type 2 diabetes mellitus [6], have a lower percentage of high-oxidative fibers in the slow soleus and fast plantaris muscles than age-matched nondiabetic rats [7]. Therefore, altered patterns of fiber types in skeletal muscles may be linked to impaired glucose tolerance and insulin resistance. Our previous study [8] showed that the decreased percentage of high-oxidative fibers in the slow soleus muscle of Goto-Kakizaki rats shifted toward normal, which is observed in age-matched nondiabetic rats, after hyperbaric exposure with high oxygen concentration. In this study, we examined whether similar effects on the fiber type distribution and oxidative enzyme activity in the fast plantaris muscle of Goto-Kakizaki rats were observed after hyperbaric exposure with high oxygen concentration. Materials and methodsFive-week-old male Wistar (n = 10) or Goto-Kakizaki (n = 10) rats were randomly assigned to the control (n = 5) or hyperbaric (n = 5) groups. All rats were individually housed in cages of the same size. The rats in the hyperbaric group were exposed to an atmospheric pressure of 1.25with an oxygen concentration of 36% automatically maintained by a computer-assisted system in a hyperbaric chamber [9]. They were exposed to the hyperbaric environment for 6 hours (10:00 to 16:00) daily for 4 weeks. Food and water were provided ad libitum for all groups. All rats were kept in a controlled environment with fixed 12:12 h light:dark cycles (lights off from 19:00 to 07:00) and room temperature maintained at 22 ± 2°C. All procedures were approved by our institutional review committee and followed the guidelines of the Physiological Society of Japan for the care and use of experimental animals.The rats were weighed and anesthetized with an intraperitoneal injection of sodium pentobarbital (50 mg/kg body weight). After blood sampli...

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Section: Discussionmentioning

confidence: 91%

Hyperbaric Exposure with High Oxygen Concentration Improves Altered Fiber Types in the Plantaris Muscle of Diabetic Goto-Kakizaki Rats

et al. 2007

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“…We determined that a pressure of 1.25 ATA and an oxygen concentration of 36% are required for obtaining effective responses with regard to oxidative metabolism [7,8]. In this study, we exposed the rats to moderate atmospheric pressure and oxygen concentration when compared to those exposed to classical hyperbaric oxygen therapy with 100% oxygen concentration at 2 ATA; we observed that these conditions of hyperbaric oxygen exposure inhibit the excessive production of ROS.…”

Section: Effects Of Exposure To Hyperbaric Oxygenmentioning

confidence: 90%

“…We determined that a pressure of 1.25 atmospheres absolute (ATA) and an oxygen concentration of 36% are required for obtaining effective responses with regard to oxidative metabolism [7,8]. Previous studies [9,10] have reported low levels of partial pressure of oxygen in the synovial fluid of arthritic joints.…”

Section: Introductionmentioning

confidence: 99%

Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis

Nagatomo

Fujino

et al. 2009

Clin Exp Med

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Arthritis was induced in 9-week-old female Dark Agouti rats by injecting type II collagen. Serum levels of the derivatives of reactive oxygen metabolites (dROMs), which are oxidative stress markers, and C-reactive protein (CRP) in arthritic rats that were exposed to a pressure of 1.25 atmospheres absolute and an oxygen concentration of 36% for 3 weeks (arthritis + HBO group) were compared to those of control rats (control group) and arthritic rats that were not exposed to hyperbaric oxygen (arthritis group). The body weights of the arthritis and arthritis + HBO groups were lower than that of the control group, whereas no difference in the body weight was observed between the arthritis and arthritis + HBO groups. The serum levels of dROMs and CRP in the arthritis group were higher than those in the control and arthritis + HBO groups. No difference in the serum level of CRP was observed between the control and arthritis + HBO groups. These results indicate that the conditions of hyperbaric oxygen exposure used in this study are effective for reducing the levels of reactive oxygen species, which are overproduced during arthritis.

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“…Muscle fiber type-specific adaptations under a variety of conditions, such as hypobaric [19] or hyperbaric [20,21] exposure and increased [22,23] or decreased [24] neuromuscular activity, are observed. Furthermore, patients with peripheral arterial disease [25] and animal models with mutation in hemoglobin [26,27], hypertension [28], or diabetes mellitus [29,30] have different patterns of fiber-type distribution compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Cell Size and Oxidative Enzyme Activity of Rat Biceps Brachii and Triceps Brachii Muscles

et al. 2007

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Fiber-type distributions, cross-sectional areas, and oxidative enzyme activities of type-identified fibers in the biceps brachii and triceps brachii muscles of 10-week-old male Wistar rats were determined and compared with those in the soleus and plantaris muscles. The soleus and plantaris muscles consisted of two (I and IIA) and three (I, IIA, and IIB) types of fibers, respectively. The deep regions of the biceps brachii and triceps brachii muscles consisted of three types of fibers, while the surface regions of those muscles consisted only of type IIB fibers. The cross-sectional areas of fibers in the deep and surface regions of the plantaris muscle and in the deep regions of the biceps brachii and triceps brachii muscles were in the rank order of type I = type IIA < type IIB, while the oxidative enzyme activities of fibers in the deep and surface regions of the plantaris muscle and in the deep region of the triceps brachii muscle were in the rank order of type IIB < type I = type IIA. These results indicate that fiber-type distributions, cross-sectional areas, and oxidative enzyme activities are muscle type-and region-specific. Therefore, the metabolic and functional significance of the biceps brachii and triceps brachii muscles, especially in the surface regions, where only type IIB fibers are located, in those muscles, appears to be determined by their fibers having larger cells and lower oxidative enzyme activity.

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Effects of Hyperbaric Exposure with High Oxygen Concentration on the Physical Activity of Developing Rats

Cited by 29 publications

References 67 publications

Hyperbaric Exposure with High Oxygen Concentration Improves Altered Fiber Types in the Plantaris Muscle of Diabetic Goto-Kakizaki Rats

Hyperbaric Exposure with High Oxygen Concentration Improves Altered Fiber Types in the Plantaris Muscle of Diabetic Goto-Kakizaki Rats

Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis

Cell Size and Oxidative Enzyme Activity of Rat Biceps Brachii and Triceps Brachii Muscles

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