Effects of hyperbaric oxygen therapy on an accelerated rate of mandibular distraction osteogenesis

Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis

“…Therefore, studies have assessed the bone‐healing effects of various adjuvant therapies in experimental MDO models . Some of the therapies reported to date include growth factors, electrical stimulation, bisphosphonates, hyperbaric oxygen, and low‐intensity pulsed ultrasound stimulation . Although many of these adjuvant therapies have shown positive results with accelerated bone healing, limitations exist.…”

“…To decrease the duration required to complete the MDO process, several strategies, including the use of various adjuvant therapies, have been studied for their potential to improve new bone formation . Although some of these were successful in initial studies, no adjuvant therapy is currently being used in the clinical setting, because most are still considered experimental (e.g., gene therapy) or impractical (e.g., need for another surgery; daily application of hyperbaric oxygen).…”

Effect of recombinant human bone morphogenetic protein‐2 on bone formation in the acute distraction osteogenesis of rat mandibles

“…Alternative methods have been proposed recently in the literature focusing on the improvement of the bone healing process, such as hyperbaric oxygen therapy during DO (Salgado et al 2009), or other competing surgical techniques, such as bone splitting (Funaki et al 2009) and bone block (Yamauchi et al 2008). The application of continuous DO to the craniofacial skeleton has the potential to greatly enhance bone formation in both complex and routine surgical treatments, despite the shortcoming posed by its need for continuous activation of the device.…”

Effects of hyperbaric oxygen therapy on biochemical and histological parameters of muscle groups in proximity to the distracted rat tibia

“…14,15 Our work focused on the surrounding soft tissue envelope that contributes to the stability of the reconstruction, with added HBOT as the variable.…”